Comparison of inflammation-based parameters and MELD-XI score with 4C mortality score in predicting in-hospital mortality in COVID-19
Öz
Purpose: In this study, we compared the roles of inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), C-reactive protein/lymphocyte ratio (CLR), monocyte/lymphocyte ratio (MLR), neutrophil/platelet ratio (NPR), neutrophil/monocyte ratio (NMR), CRP/albumin ratio (CAR), BUN/albumin ratio (BAR), MELD-XI score and 4C mortality score in predicting in-hospital mortality risk in COVID-19.
Materials and Methods: A total of 117 patients over 18 years old with a PCR-confirmed diagnosis of COVID-19 between June 2020 and February 2021 were retrospectively included. The roles of parameters for independently predicting in-hospital mortality were determined and compared with each other using appropriate statistical methods.
Results: Age, chronic kidney disease, diabetes mellitus, acute kidney injury, and length of hospital stay, urea, creatinine, LDH, AST, ferritin, D-dimer, CRP, albumin, Hb, CLR, BAR, CAR, MELD-XI score, and 4C mortality score were significantly correlated to in-hospital mortality. However, only the 4C mortality score and AST independently predicted in-hospital mortality in COVID-19 [OR 2.08 (%95 CI 1.06-2.36), for 4C mortality score, and OR 1.05 (%95 CI 1.00-1.10), for AST].
Conclusion: Unlike other mortality-related inflammatory parameters, the 4C mortality score and AST were independent and strong predictors of mortality in hospitalized COVID-19 patients.
Anahtar Kelimeler
AST, COVID-19, inflammatory parameters, 4C mortality score, MELD-XI score
Destekleyen Kurum
Başkent Üniversitesi Tıp Fakültesi
Proje Numarası
KA21/288
Kaynakça
- WHO (World Health Organization). WHO Coronavirus (COVID-19) dashboard. https://covid19.who.int/(accessed Dec 2021).
- Aziz M, Fatima R, Lee-Smith W, Assaly R. The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis. Crit Care. 2020;24:255.
- Henry BM, Aggarwal G, Wong J, Benoit S, Vikse J, Plebani M et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis. Am J Emerg Med. 2020;38:1722-6.
- Ullah W, Basyal B, Tariq S, Almas T, Saeed R, Roomi S et al. Lymphocyte-to-C-reactive protein ratio: A novel predictor of adverse outcomes in COVID-19. J Clin Med Res. 2020;12:415-22.
- Wu T, Zuo Z, Kang S, Jiang L, Luo X, Xia Z et al. Multi-organ dysfunction in patients with COVID-19: A systematic review and meta-analysis. Aging Dis. 2020;11:874-94.
- Seyit M, Avcı E, Nar R, Senol H, Yılmaz A, Özen M et al. Neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio and platelet to lymphocyte ratio to predict the severity of COVID-19. Am J Emerg Med. 2021;40:110-4.
- Ok F, Erdoğan O, Durmuş E, Çarkcı S, Canik A. Predictive values of blood urea nitrogen/creatinine ratio and other routine blood parameters on disease severity and survival of COVID-19 patients. J Med Virol. 2021;93:786-93.
- Küçükceran K, Ayrancı MK, Girişgin AS, Koçak S, Dündar ZD. The role of the BUN/albumin ratio in predicting mortality in COVID-19 patients in the emergency department. Am J Emerg Med. 2021;48:33-7.
- Becerra-Munoz VM, Nunez-Gil IJ, Eid CM, Aguado MG, Romero R, Huang J et al. Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19. Age Ageing. 2021;50:326-34.
- Pan F, Jang L, Li Y, Liang B, Li L, Ye T et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020;17:1281-92.
