Multipl sklerozda spinal kord lezyonları ile kognisyon ilişkisi

Sevda Diker; Amber Eker; Doç Dr Bahar Kaymakamzade; Aysegul Erem; Uğurcan Balyemez

doi:10.17826/cumj.1096925

EN TR

Association of spinal cord lesions with cognition in multiple sclerosis

Abstract

Purpose: The effect of spinal cord involvement, which is closely related to physical disability and prognosis, on cognitive functions in multiple sclerosis. Materials and Methods: Twenty nine MS patients (2 clinically isolated syndrome, 23 relapsing and remitting MS, 2 secondary progressive MS, 2 primary progressive MS) were included in the study. Demographic characteristics, expanded disability status scale (EDSS) score, cognition assessed by brief repeatable battery of neuropsychological tests, brain and spinal cord T2 lesion number were evaluated. Results: Older age, later age of disease onset, education duration are the features affecting cognitive test results. Brain and spinal cord lesion numbers did not have any effect on cognitive tests. Patients with spinal cord lesions had higher EDSS compared to patients without, however there was no difference regarding cognitive test results between groups. Conclusion: Spinal cord lesions are associated with physical disability quantified by EDSS. Longitudinal studies with larger samples are needed to investigate the effect of presence and number of cord lesions as well as cervical cord atrophy on cognitive test results.

Keywords

Multiple sclerosis , spinal cord , cognition , BRB-N

Multipl sklerozda spinal kord lezyonları ile kognisyon ilişkisi

Öz

Amaç: Çalışmamızda, multipl skleroz (MS)da fiziksel özürlülük ve prognozla yakın ilişkisi olan spinal kord tutulumunun, kognitif işlevler üzerine olası etkisi incelenmiştir. Gereç ve Yöntem: Çalışmaya 29 MS hastası (2 klinik izole sendrom, 23 relaps ve remisyonlarla seyreden MS, 2 sekonder progresif MS, 2 primer progresif MS) alındı. Demografik özellikleri, genişletilmiş özürlülük durum skalası (EDSS) skoru, Rao’nun kısa tekrarlanabilir nöropsikolojik test bataryası ile değerlendirilen kognitif durumu, beyin ve spinal kord T2 lezyon sayısı değerlendirildi. Benzer demografik özelliklere sahip 17 sağlıklı kontrol ile kognitif test sonuçları karşılaştırıldı. Bulgular: İleri yaş, hastalık başlangıç yaşının ileri olması, kısa eğitim süresi kognitif test sonuçlarını olumsuz etkileyen özelliklerdir. Beyin ve spinal kord lezyon sayılarının kognitif testler üzerine anlamlı etkisi saptanmamıştır. Spinal kord lezyonu olan hastalar olmayanlara göre daha yüksek EDSS’ye sahiptir, ancak iki grup arasında kognitif test sonuçları açısından anlamlı farklılık saptanmamıştır. Sonuç: Spinal kord lezyonları, EDSS ile değerlendirilen fiziksel özürlülük ile ilişkilidir. Kord plak varlığının ya da sayısının kognitif test sonuçları üzerine etkisini, servikal kord atrofisi ile birlikte değerlendirecek, daha geniş örneklemli boylamsal çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

multipl skleroz , spinal kord , kognisyon , BRB-N

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Sevda Diker ^*
0000-0002-8944-0672
Kuzey Kıbrıs Türk Cumhuriyeti

Amber Eker
0000-0001-9997-4662
Kuzey Kıbrıs Türk Cumhuriyeti

Doç Dr Bahar Kaymakamzade
0000-0001-9495-6203
Kuzey Kıbrıs Türk Cumhuriyeti

Aysegul Erem
0000-0002-7713-5005
Kuzey Kıbrıs Türk Cumhuriyeti

Uğurcan Balyemez
0000-0001-6845-0081
Kuzey Kıbrıs Türk Cumhuriyeti

Yayımlanma Tarihi

30 Eylül 2022

Gönderilme Tarihi

3 Nisan 2022

Kabul Tarihi

17 Temmuz 2022

Yayımlandığı Sayı

Yıl 1970 Cilt: 47 Sayı: 3

DOI

https://doi.org/10.17826/cumj.1096925

IZ

https://izlik.org/JA45GR53CR

MLA

Diker, Sevda, vd. “Multipl sklerozda spinal kord lezyonları ile kognisyon ilişkisi”. Cukurova Medical Journal, c. 47, sy 3, Eylül 2022, ss. 1040-9, doi:10.17826/cumj.1096925.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Association of spinal cord lesions with cognition in multiple sclerosis

Abstract

Keywords

Multipl sklerozda spinal kord lezyonları ile kognisyon ilişkisi

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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