Association between surfactant protein B gene locus and acute bronchiolitis in infants

Sümeyya Deniz Aybek; Ömer Ateş; Saime Sezer Sondaş; Ali Gül; Şahin Takçı; Buket Altıntaş Seyyah

doi:10.17826/cumj.1124468

TR EN

Bebeklerde akut bronşiolit ve surfaktan protein B gen lokusu arasındaki ilişki

Öz

Amaç: Çalışmamızda surfaktan protein B (SFTPB) C1580T polimorfizmi ile akut bronşiolit arasında bir ilişki olup olmadığını araştırmayı amaçladık. Gereç ve Yöntem: Bu çalışmada, polimeraz zincir reaksiyonu- restriksiyon parça uzunluk polimorfizmi (PZR-RFLP) tekniği kullanılarak 103 akut bronşiolitli bebekte ve 102 sağlıklı bebekte SFTB C1580T gen polimorfizminin alel sıklığı ve genotip dağılımı analiz edildi. Bulgular: Bu sonuçlar SFTPB C1580T polimorfizmi ve akut bronşiolitin klinik özellikleri arasında bir ilişki olmadığını gösterdi. CT genotipinin dağılımı akut bronşiolitli bebeklerde (%43) kontol grubuna (%39) göre daha yüksektir ve TT genotipinin dağılımı akut bronşiolitli bebeklerde (%38) kontol grubuna (%41) göre daha düşüktür. Hasta ve kontrol grubu arasında SFTPB C1580T polimorfizmi için genotip dağılımı ve allel sıklığında önemli bir fark yoktur. Sonuç: SFTPB C1580T gen polimorfizminin akut bronşiolite yatkınlıkta önemli bir rolü olmadığı saptanmıştır. Çalışma sonuçlarımızın doğrulanabilmesi için SFTPB C1580T polimorfizminin ilişkisinin ileri ve daha büyük kohort çalışmaları yapılarak değerlendirilmesine ihtiyaç vardır.

Anahtar Kelimeler

Akut bronşiolit , genetik polimorfizm , SFTPB geni , surfaktan protein , Acute bronchiolitis , genetic polymorphism , SFTPB gene , surfactant protein

Association between surfactant protein B gene locus and acute bronchiolitis in infants

Abstract

Purpose: The aim of this study was to investigate whether there is a relationship between surfactant protein B (SFTPB) C1580T polymorphism and acute bronchiolitis. Materials and Methods: The study analyzed the allele frequency and genotype distribution for the SFTPB C1580T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 103 acute bronchiolitis infants and 102 healthy infants. Results: The results showed no association between SFTPB C1580T polymorphism and clinical characteristics of acute bronchiolitis. The distribution of the CT genotype was higher in acute bronchiolitis infants (43%) than in healthy subjects (39%) and distribution of the TT genotype was found lower in acute bronchiolitis infants (38%) than in healthy subjects (41%). No significant differences in genotype distribution and allele frequency for the SFTPB C1580T polymorphism were found between case group and control group Conclusion: SFTPB C1580T gene polymorphism plays no important role in susceptibility to acute bronchiolitis. Further work on the relevance of SFTPB C1580T polymorphism in larger cohorts will require validating our results.

Keywords

Acute bronchiolitis , genetic polymorphism , SFTPB gene , surfactant protein

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Sümeyya Deniz Aybek ^*
0000-0001-9957-5485
Türkiye

Ömer Ateş
0000-0003-4266-393X
Türkiye

Saime Sezer Sondaş
0000-0002-7849-3445
Türkiye

Ali Gül
0000-0001-5350-2192
Türkiye

Şahin Takçı
0000-0001-9836-9727
Türkiye

Buket Altıntaş Seyyah
0000-0001-7010-0283
Türkiye

Yayımlanma Tarihi

28 Aralık 2022

Gönderilme Tarihi

1 Haziran 2022

Kabul Tarihi

5 Eylül 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 47 Sayı: 4

DOI

https://doi.org/10.17826/cumj.1124468

IZ

https://izlik.org/JA64CL23LH

MLA

Aybek, Sümeyya Deniz, vd. “Association between surfactant protein B gene locus and acute bronchiolitis in infants”. Cukurova Medical Journal, c. 47, sy 4, Aralık 2022, ss. 1440-6, doi:10.17826/cumj.1124468.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Bebeklerde akut bronşiolit ve surfaktan protein B gen lokusu arasındaki ilişki

Öz

Anahtar Kelimeler

Association between surfactant protein B gene locus and acute bronchiolitis in infants

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster