Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia
Öz
Purpose: In this study, we aimed to investigate the effects of serum neuron specific enolase on the prediction of central nervous system injury and the clinical course in patients to have hyponatremia.
Materials and Methods: 75 adult patients with serum sodium levels less than 135 mEq/L were evaluated. The patients were grouped according to serum neuron specific enolase levels (group 1 ≤ 17.0 ng/mL and group 2 > 17.0 ng/mL). The groups were compared according to demographic and laboratory data.
Results: The incidence of hypertension, heart failure, and loss of consciousness was significantly higher in group 2 patient. High neuron specific enolase levels were related to lower serum sodium levels. The mean sodium levels were 129.5 ± 4.3 mEq/L and 126 ± 4.5 mEq/L in groups 1 and 2, respectively. Of the patients in group 2 (n = 45), 8 patients with loss of consciousness (low Glasgow Coma Scale scores) (i.e. <15)) had significantly higher serum neuron specific enolase levels than the rest of the patients in group 2 (n = 37) (37.1 ± 6.9 and 18.6 ± 8.8).
Conclusion: High neuron specific enolase levels are associated with lower sodium levels and low Glasgow Coma Scale scores. In patients with hyponatremia, we think that neuron specific enolase monitoring can predict which patients may experience a change in consciousness.
Anahtar Kelimeler
Emergency department, Hyponatremia, Loss of consciousness, Neuron specific enolase
Destekleyen Kurum
Çukurova Üniversitesi Yayın Teşvik
Kaynakça
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