Comparison of early atherosclerosis markers in children with Celiac disease and their healthy peers

Derya Karpuz; Özlem Tezol; Merve Türkegün; Yusuf Usta

doi:10.17826/cumj.1166923

EN TR

Comparison of early atherosclerosis markers in children with Celiac disease and their healthy peers

Abstract

Purpose: We aimed to evaluate carotid intima-media thickness (cIMT) and epicardial adipose tissue thickness (EATT) concurrently as early atherosclerotic markers in pediatric patients with Celiac disease. Materials and Methods: Patients with Celiac disease (n=54) and healthy peers (n=54) aged 5-18 years were enrolled in this cross-sectional study. Patients who followed gluten free diet at least the past 12 months were included. Anthropometric and biochemical measurements were performed. cIMT and EATT were measured by echocardiography and compared between the patient and control groups. Results: Body mass index (17.4±3.0 vs. 18.4±3.1 kg/m2), blood pressure (systolic: 100 (85-120) vs. 100 (80-100) mmHg; diastolic: 60 (40-90) vs. 70 (40-90) mmHg), and lipid profile (total cholesterol: 144.6±30.2 vs. 150.8±22.6 mg/dL; triglycerides: 71.5 (27-178) vs. 92.5 (34-203) mg/dL) were not different between the patient and control groups, while there were significant differences in cIMT and EATT. The patient group had higher cIMT (0.50±0.07 vs. 0.45±0.04 mm) and EATT (5.68±0.90 vs. 4.22±0.76 mm) than the control group. The risk of vitamin D insufficiency was 2.68 times higher in the patient group (95% CI=1.19-6.03). Conclusions: Children with Celiac disease had higher cIMT and EATT than healthy peers. cIMT and/or EATT measurements by echocardiography may present as a reliable and easy method to investigate subclinical atherosclerosis in children with Celiac disease.

Keywords

atherosclerosis , carotid intima media thickness , Celiac , children , epicardial adipose tissue thickness

Çölyak hastalığı olan çocuklar ile sağlıklı yaşıtlarının erken ateroskleroz belirteçlerinin karşılaştırılması

Öz

Amaç: Bu çalışmada, pediatrik yaş grubundaki Çölyak hastalarının karotis intima-media kalınlığının (KİMK) ve epikardiyal yağ doku kalınlığının (EYDK) değerlendirilmesi amaçlandı. Gereç ve Yöntem: Bu kesitsel çalışmada, 5-18 yaş aralığındaki Çölyak hastaları (n=54) ve sağlıklı yaşıtları (n=54) yer aldı. En az son 12 aydır glutensiz diyet uygulayan hastalar dahil edildi. Antropometrik ve biyokimyasal ölçümler yapıldı. Ekokardiyografi ile ölçülen KİMK ve EYDK değerleri hasta ve kontrol grupları arasında karşılaştırıldı. Bulgular: Hasta ve kontrol gruplarında beden kitle indeksi (17,4±3,0’a karşı 18,4±3,1 kg/m2), kan basıncı (sistolik: 100 (85-120)’e karşı 100 (80-100); diastolik: 60 (40-90)’a karşı 70 (40-90) mmHg) ve lipid profili (total kolesterol: 144,6±30,2’ye karşı 150,8±22,6; trigliserid: 71,5 (27-178)’e karşı 92,5 (34-203) mg/dL) farklılık göstermedi. Hasta grubunda KİMK ve EYDK, kontrol grubuna göre istatistiksel anlamlılıkta daha yüksek saptandı (KİMK: 0,50±0,07 mm’ye karşı 0,45±0,04 mm; EYDK: 5,68±0,90 mm’ye karşı 4,22±0,76 mm). D vitamini yetersizliği riski hasta grubunda 2,68 kat yüksek bulundu (%95 Güven Aralığı = 1,19-6,03). Sonuç: Çölyak hastalığı olan çocukların sağlıklı yaşıtlarından daha yüksek KİMK ve EYDK değerlerine sahip olduğu görüldü. Ekokardiyografik KİMK ve/veya EYDK ölçümleri, Çölyak hastalığı olan çocuklarda subklinik aterosklerozu değerlendirmenin güvenilir ve basit bir yöntemi olabilir.

Anahtar Kelimeler

ateroskleroz , karotis intima-media kalınlığı , Çölyak , çocuk , epikardiyal yağ doku kalınlığı

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Derya Karpuz
0000-0002-3007-1403
Türkiye

Özlem Tezol ^*
0000-0001-9994-7832
Türkiye

Merve Türkegün
0000-0002-4405-521X
Türkiye

Yusuf Usta
0000-0002-0101-6501
Türkiye

Yayımlanma Tarihi

28 Aralık 2022

Gönderilme Tarihi

25 Ağustos 2022

Kabul Tarihi

21 Kasım 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 47 Sayı: 4

DOI

https://doi.org/10.17826/cumj.1166923

IZ

https://izlik.org/JA45PA92YH

MLA

Karpuz, Derya, vd. “Comparison of early atherosclerosis markers in children with Celiac disease and their healthy peers”. Cukurova Medical Journal, c. 47, sy 4, Aralık 2022, ss. 1600-9, doi:10.17826/cumj.1166923.

Cited By

Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis

BMC Pediatrics

https://doi.org/10.1186/s12887-024-04688-0

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Comparison of early atherosclerosis markers in children with Celiac disease and their healthy peers

Abstract

Keywords

Çölyak hastalığı olan çocuklar ile sağlıklı yaşıtlarının erken ateroskleroz belirteçlerinin karşılaştırılması

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis