Effect of folic acid supplementation on mental health in the antenatal and postnatal period
Öz
Purpose: The aim of the study was to examine the mental health outcomes of folic acid (FA) supplement use in the antenatal and postnatal periods.
Materials and Methods: This descriptive-prospective longitudinal study was conducted between 1 December 2019 and 30 January 2021 in a Family Health Center in eastern Turkey. The study was performed at one week in the postpartum period, at 6-8 weeks in the postpartum period, and at six months in the postpartum period. A total of 162 healthy pregnant women were included in the study. A Personal Information Form, the Beck Anxiety Inventory (BAI), and the Edinburgh Postpartum Depression Scale (EPDS) were used to collect data.
Results: While 32.7% (n=53) of the participants used FA supplementation from the pre-pregnancy period and in the first trimester of pregnancy (6 months in total), and 34.6% (n=56) used FA supplementation only in the first trimester of pregnancy. It was determined that 32.7% (n=53) of the participants did not use any FA supplement. Of those who did not use FA, 37.0% were in the antenatal period, and 50.8% were on the postnatal 6-8 days. It was determined that the participants experienced mild/moderate/severe anxiety in different weeks. BAI and EPDS scores were the lowest in the prenatal period, at 6-8 weeks in the postpartum period, and at 6 months in the postpartum period in those who used FA supplementation for 6 months. BAI and EPDS scores decreased significantly from the antenatal, to the postnatal 6-8-week, and to the postnatal 6-month measurements.
Conclusion: The use of FA supplements can be effective in preventing symptoms of anxiety and depression in the antenatal and postnatal period.
Anahtar Kelimeler
Destekleyen Kurum
Yok
Proje Numarası
yok
Kaynakça
- World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization, 2016.
- Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, et al. Folic acid supplementation for the prevention of neural tube defects: US Preventive Services Task Force recommendation statement. JAMA 2017;317:183–9.
- World Health Organization. (2017). Global diffusion of eHealth: making universal health coverage achievable: report of the third global survey on eHealth. World Health Organization.
- Güler B, Bilgiç D, Okumuş H, Yağcan H. Gebelikte beslenme desteğine ilişkin güncel rehberlerin incelenmesi. Dokuz Eylül Üniversitesi Hemşirelik Fakültesi Elektronik Dergisi 2019;12:143-151.
- Toivonen KI, Lacroix E, Flynn M, et al. Folic acid supplementation during the preconception period: a systematic review and meta-analysis. Preventive medicine 2018;114:1-17.
- Baykan Z, Ozturk A, Poyrazoglu S, Gun I. Awareness, knowledge, and use of folic acid among women: a study from Turkey. Archives of Gynecology and Obstetrics 2011;283:1249–1253. Basgul A, Akici A, Uzuner A, et al. Drug utilization and teratogenicity risk categories during pregnancy. Advances in Therapy 2007;24: 68–80. Özer A, Özer S, Pektaş Kanat M, et al. How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine 2016;7:538-541.
- Yan J, Liu Y, Cao L, et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression. Nutrients 2017;9:1206.
- Papakostas GI, Shelton RC, Zajecka JM, et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatr. 2012;169:1267–74.
- Perez-Cornago A, Lopez-Legarrea P, Iglesia RDL, et al. Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: the RESMENA project. Clin Nutr. 2014;33:1061–7
- Murakami K, Sasaki S. Dietary intake and depressive symptoms: a systematic review of observational studies. Molecular nutrition & food research 2010;54: 471-488.
