A case of normocalcemic primary hyperparathyroidism presenting with a mass in the oral cavity and accompanying incidental papillary thyroid carcinoma

Emek Topuz; Dilek Tüzün; Ümit Nur Özbay; Murat Şahin; İrfan Kara

doi:10.17826/cumj.1184876

EN TR

A case of normocalcemic primary hyperparathyroidism presenting with a mass in the oral cavity and accompanying incidental papillary thyroid carcinoma

Abstract

Hyperparathyroidism (HPT) is an endocrine disorder characterized by high secretion of parathyroid hormone. Brown tumor is one of the skeletal manifestations of HPT. Its overall prevalence is low (about 0.1%). Involvement of facial bones is extremely rare. The mandible is involved in 4.5% of cases. Primary HPT (PHPT)with vitamin D deficiency worsens the clinical course. Parathyroid adenoma is detected in ectopic places with a rate of 8.5%. 0.2% is intrathyroidal, 2% is located in different neck regions, 4.1% is in the upper mediastinum, and 2.2% is in the lower mediastinum. The prevalence of papillary thyroid cancer (PTC) in PHPT patients has been reported to range from 2% to 15%. In the literature, incidentally detected papillary thyroid cancer in patients with hyperparathyroidism was detected in patients who underwent total thyroidectomy associated with intrathyroidal parathyroid adenoma. In this article, we present a case of incidental papillary thyroid carcinoma with ectopic parathyroid adenoma accompanied by severe vitamin D, and diagnosed during accompanying surgery following a brown tumor was considered after primary hyperparathyroidism was detected. However, the patient was admitted with a mass in the oral cavity, diagnosed before as a pyogenic granuloma with a delayed diagnosis without considering brown tumor because it was normocalcemic. It is the first case in the literature of papillary thyroid carcinoma detected incidentally with ectopic parathyroid adenoma in the thyrothymic region.

Keywords

brown tumor , ectopic parathyroid adenoma , normocalcemic hyperparathyroidism , papillary thyroid cancer

Oral kavitede kitle ve eşlik eden insidental papiller tiroid karsinomu ile başvuran normokalsemik primer hiperparatiroidizm olgusu

Öz

Hiperparatiroidizm (HPT), yüksek paratiroid hormonu salgılanması ile karakterize bir endokrin bozukluktur. Brown tümör, HPT'nin iskelet belirtilerinden biridir. . Genel prevalansı düşüktür (yaklaşık %0,1) .Yüz kemikleri tutulumu son derece nadirdir. Mandibula vakaların %4,5’inde tutulur. D vitamini eksikliği ile birlikte olan Primer HPT (PHPT) klinik gidişi kötüleştirir. Paratroid adenomu %8.5 oranında ektopik yerlerde tespit edilir. %0.2 intratroidial ,%2 si boyunda farklı bölgelerde ve, %4.1 üst mediastende ve %2.2 alt mediastende bulunur. PHPT hastalarında, papiller tiroid kanseri (PTC) prevalansının %2 ila %15 arasında olduğunu bildirmiştir. . Literatürde hiperparatroidili hastalarda insidental olarak saptanan tiroid papiller kanseri intratroidial paratroid adenomu birlikteliğinde total troidektomi yapılan hastalarda saptanmıştır. Biz bu yazıda, oral kavitede kitle ile başvurmuş, normokalsemik olduğu için önce brown tümör düşünülmeyen bu nedenle tanısı geciken piyojenik granülom tanısı alan , primer hiperparatiroidizm saptandıktan sonra brown tümör düşünülen, ciddi D vitaminin eşlik ettiği ektopik paratiroid adenomu ve buna eşlik eden cerrahi sırasında tanı konan insidental tiroid papiller karsinomu olgusunu sunuyoruz. Tirotimik bölgede ektopik paratiroid adenomu ile birlikte insidental olarak saptanan tiroid papiller karsinomu vakası olarak literatürdeki ilk vakadır.

Anahtar Kelimeler

brown tümör , ektopik paratiroid adenomu , normokalsemik hiperparatroidizm , papiller tiroid kanseri

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Editöre Mektup

Yazarlar

Emek Topuz ^*
0000-0001-7265-2321
Türkiye

Dilek Tüzün
0000-0002-6693-4928
Türkiye

Ümit Nur Özbay
0000-0003-4660-9690
Türkiye

Murat Şahin
0000-0001-7969-9157
Türkiye

İrfan Kara
0000-0003-3884-3014
Türkiye

Yayımlanma Tarihi

28 Aralık 2022

Gönderilme Tarihi

5 Ekim 2022

Kabul Tarihi

16 Kasım 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 47 Sayı: 4

DOI

https://doi.org/10.17826/cumj.1184876

IZ

https://izlik.org/JA22DR46JU

MLA

Topuz, Emek, vd. “A case of normocalcemic primary hyperparathyroidism presenting with a mass in the oral cavity and accompanying incidental papillary thyroid carcinoma”. Cukurova Medical Journal, c. 47, sy 4, Aralık 2022, ss. 1764-7, doi:10.17826/cumj.1184876.

Cited By

Concurrent papillary thyroid carcinoma, normocalcemic primary hyperparathyroidism, and incidental struma ovarii in a young woman: a case report

Annals of Medicine & Surgery

https://doi.org/10.1097/MS9.0000000000004844

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

A case of normocalcemic primary hyperparathyroidism presenting with a mass in the oral cavity and accompanying incidental papillary thyroid carcinoma

Abstract

Keywords

Oral kavitede kitle ve eşlik eden insidental papiller tiroid karsinomu ile başvuran normokalsemik primer hiperparatiroidizm olgusu

Öz

Anahtar Kelimeler

Kaynakça

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Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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Cited By

Concurrent papillary thyroid carcinoma, normocalcemic primary hyperparathyroidism, and incidental struma ovarii in a young woman: a case report