Total fertilization failure in intracytoplasmic sperm injection: a retrospective comparative study

Hasan İnal; Zeynep Ozturk Inal

doi:10.17826/cumj.1221276

EN TR

Total fertilization failure in intracytoplasmic sperm injection: a retrospective comparative study

Abstract

Purpose: The aim of this study was to evaluate total fertilization failure (TFF), embryo transfers following TFF cycles, and recurrent TFF, and to define the factors that might cause TFF. Materials and Methods: Cycles that resulted in TFF (group 1, n=109), embryo transfers after TFF cycles (group 2, n=30), and cases of recurrent TFF (group 3, n=15) were evaluated retrospectively. Results: Peak estradiol was higher in group 2 than other groups, and the rate of sperm morphology below 4% was lower in group 2 when compared to groups 1 and 3. The total numbers of retrieved oocytes (5.3±4.1 vs 10.2±1.5 (Odds Ratio=1.639; 95% CI 1.267-2.122)) and MII oocytes (2.9±2.2 vs 6.8±1.8 (Odds Ratio=2.218; 95% CI 1.529-3.216)) were significantly higher in embryo transfer cycles when compared to previous TFF cycles. Retrieved and MII oocytes counts were higher in group 2 with a median fertilization rate of 46.42% when compared to groups 1 and 3. Conclusion: With more retrieved and MII oocytes, normal sperm morphology can increase the fertilization rate of ICSI cycles following earlier TFF.

Keywords

infertility , intracytoplasmic sperm injection , perinatal outcomes , total fertilization failure

İntrasitoplazmik sperm enjeksiyonunda döllenme başarısızlığı: retrospektif karşılaştırmalı bir çalışma

Öz

Amaç: Bu çalışmada total fertilizasyon başarısızlığı (TFF), TFF siklusları sonrası embriyo transferleri ve tekrarlayan TFF'yi değerlendirmek ve TFF'ye neden olabilecek faktörlerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: TFF ile sonuçlanan sikluslar (grup 1, n=109), TFF siklusları sonrası embriyo transferleri (grup 2, n=30) ve tekrarlayan TFF olguları (grup 3, n=15) retrospektif olarak değerlendirildi. Bulgular: Pik estradiol grup 2'de diğer gruplara göre daha yüksekti, %4'ün altında sperm morfolojisi oranı grup 2'de grup 1 ve 3'e göre daha düşüktü. Elde edilen toplam oosit sayısı (5,3±4,1 vs 10,2±1,5 (Odds Ratio=1,639; %95 CI 1,267-2,122) ve MII oositleri (2,9±2,2 vs 6,8±1,8 (Odds Ratio=2,218; 95) % CI 1,529-3,216;) embriyo transfer sikluslarında önceki TFF sikluslarına göre anlamlı derecede yüksekti. Elde edilen ve MII oosit sayısı medyan fertilizasyon oranı %46.42 ile grup 1 ve 3'e göre grup 2'de daha yüksekti. Sonuç: Daha fazla toplanan ve MII oositlerle, normal sperm morfolojisi, erken TFF'yi takiben ICSI sikluslarının fertilizasyon oranını artırabilir.

Anahtar Kelimeler

infertilite , intrasitoplazmik sperm enjeksiyonu , perinatal sonuçlar , total fertilizasyon başarısızlığı

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Hasan İnal ^*
0000-0002-8361-7908
Türkiye

Zeynep Ozturk Inal
0000-0002-8766-2079
Türkiye

Yayımlanma Tarihi

31 Mart 2023

Gönderilme Tarihi

19 Aralık 2022

Kabul Tarihi

1 Şubat 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 48 Sayı: 1

DOI

https://doi.org/10.17826/cumj.1221276

IZ

https://izlik.org/JA87SB93WG

MLA

İnal, Hasan, ve Zeynep Ozturk Inal. “Total fertilization failure in intracytoplasmic sperm injection: a retrospective comparative study”. Cukurova Medical Journal, c. 48, sy 1, Mart 2023, ss. 168-76, doi:10.17826/cumj.1221276.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Total fertilization failure in intracytoplasmic sperm injection: a retrospective comparative study

Abstract

Keywords

İntrasitoplazmik sperm enjeksiyonunda döllenme başarısızlığı: retrospektif karşılaştırmalı bir çalışma

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster