Lamellar macular hole following intravitreal aflibercept injection in a patient with neovascular age-related macular degeneration
Abstract
Purpose: To report a case where a lamellar macular hole (LMH) developed following intravitreal injection of aflibercept due to neovascular age-related macular degeneration (nAMD).
Material and Methods: A 70-year-old man diagnosed with nAMD underwent intravitreal aflibercept injections for three consecutive months. At follow up, the resolution of the subretinal fluid was revealed by optical coherence tomography (OCT), and a visual improvement was observed. One month later, visual impairment occurred with respect to the activation of the neovascular membrane. Hence, intravitreal injection of aflibercept was performed again.
Results: The LMH developed after one month following the last injection, as demonstrated by OCT, in addition to the resolution of subretinal fluid and some visual improvement.
Conclusion: To our knowledge, this is the first case study reporting such LMH formation after intravitreal aflibercept injection. The literature was evaluated for mechanisms in explaining the formation of LMH after aflibercept injection.
Keywords
Aflibercept , age-related macular degeneration intravitreal injection , lamellar macular hole
Kaynakça
- Schulze S, Hoerle S, Mennel S, Kroll P. Vitreomacular traction and exudative age-related macular degeneration. Acta Ophthalmol. 2008;86:470-81.
- Govetto A, Dacquay Y, Farajzadeh M, Platner E, Hirabayashi K, Hosseini H et al. Lamellar macular hole: Two distinct clinical entities? Am J Ophthalmol. 2016;164:99-109.
- Francone A, Yun L, Kothari N, Cheng I, Farajzadeh M, Govetto A et al. Lamellar macular holes in the presence of age-related macular degeneration. Retina. 2020;40:1079-86.
- Bhattacharya S, Chaum E, Johnson DA, Johnson LR. Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association. Invest Ophthalmol Vis Sci. 2012;53:8350-66.
- Grigoropoulos V, Emfietzoglou J, Nikolaidis P, Theodossiadis G, Theodossiadis P. Full-thickness macular hole after intravitreal injection of ranibizumab in a patient with retinal pigment epithelium detachment and tear. Eur J Ophthalmol. 2010;20:469-72.
- Erdurman FC, Pellumbi A, Durukan AH. Lamellar macular hole formation in a patient with diabetic CME treated by intravitreal bevacizumab injections. Ophthalmic surgery, lasers imaging Off J Int Soc Imaging Eye. 2012;43 Online:e87-9.
- Torabi H, Jadidi K, Naderi M. Lamellar macular hole formation following intravitreal bevacizumab injection for choroidal neovascularization by age-related macular degeneration. Oman J Ophthalmol. 2018;11:277-9.
- Romano MR, Vallejo-Garcia JL, Camesasca FI, Vinciguerra P, Costagliola C. Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes. Eye (Lond). 2012;26:810-5.
- Zhang Z-H, Liu H-Y, Hernandez-Da Mota SE, Romano MR, Falavarjani KG, Ahmadieh H et al. Vitrectomy with or without preoperative intravitreal bevacizumab for proliferative diabetic retinopathy: a meta-analysis of randomized controlled trials. Am J Ophthalmol. 2013;156:106-115.e2.
- Van Geest RJ, Lesnik-Oberstein SY, Tan HS, Mura M, Goldschmeding R, Van Noorden CJF et al. A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy. Br J Ophthalmol. 2012;96:587-90.
