Effect of sex and mode of delivery on systemic inflammatory indices in preterm infants

Ufuk Çakır; Cüneyt Tayman

doi:10.17826/cumj.1366249

TR EN

Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

Öz

Amaç: Neonatoloji alanında sistemik inflamatuar indekslere ilişkin bilgiler sınırlıdır. Cinsiyet ve doğum şeklinin sistemik inflamatuar indeksleri nasıl etkilediği bilinmemektedir. Çalışmamızın amacı preterm bebeklerde doğum şeklinin ve cinsiyetin sistemik inflamatuar indekslere etkisini değerlendirmektir. Gereç ve Yöntem: 32 haftanın altındaki prematüre bebekler retrospektif olarak değerlendirildi. Tam kan sayımı parametreleri, monosit-lenfosit oranı (MLR), nötrofil-lenfosit oranı (NLR), pan immün inflamasyon değeri (PIV), trombosit-lenfosit oranı (PLR), sistemik immün inflamasyon indeksi (SII), sistemik inflamasyon yanıt indeksi (SIRI), demografik ve klinik özellikler cinsiyet ve doğum şekli açısından karşılaştırıldı. Bulgular: Çalışmamızda 1322 prematüre bebek değerlendirildi. Lökosit, trombosit, nötrofil, monosit, lenfosit sayısı, hemoglobin düzeyleri, NLR, MLR, PLR, PIV, SII ve SIRI değerleri cinsiyetler arasında benzer bulundu. Lökosit, nötrofil, monosit, lenfosit sayısı, hemoglobin düzeyleri, MLR, PLR ve SIRI değerleri doğum şekline göre anlamlı farklılık göstermedi. Sezaryen grubunda trombosit sayısı (225 103 µ/L), NLR (0,30), PIV (42,17) ve SII (67,86) değerleri vajinal doğum grubuna (trombosit sayısı: 248 103 µ/L, NLR: 0,44, PIV: 80,88 ve SII: 91.63) göre daha düşüktü. Sonuç: Çalışmamızda cinsiyetin sistemik inflamatuar indeksler üzerine etkisinin olmadığı ve <32 haftadan önce doğan prematüre bebeklerde sezaryen doğumda NLR, PIV ve SII'nin daha düşük olduğu gösterilmiştir.

Anahtar Kelimeler

Yenidoğan , Nötrofil-lenfosit oranı , Pan immün inflamasyon değeri , Prematüre , Sistemik immün inflamasyon indeksi

Effect of sex and mode of delivery on systemic inflammatory indices in preterm infants

Abstract

Purpose: Information on systemic inflammatory indices in the field of neonatology is limited. How sex and mode of delivery affects systemic inflammatory indices is unknown. The aim of our study was to evaluate the effect of mode of delivery and sex on systemic inflammatory indices in preterm infants. Materials and Methods: Preterm infants <32 weeks of gestation were evaluated retrospectively. Complete blood count parameters, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), pan immune inflammation value (PIV), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI), demographic and clinical characteristics were compared in terms of sex and mode of delivery. Results: In our study, 1322 preterm infants were evaluated. Leukocyte, platelet, neutrophil, monocyte, lymphocyte count, hemoglobin levels, NLR, MLR, PLR, PIV, SII, and SIRI values were found to be similar between genders. Leukocyte, neutrophil, monocyte, lymphocyte count, hemoglobin levels, MLR, PLR, and SIRI values did not differ significantly according to mode of delivery. The values of platelet count (225 103 µ/L), NLR (0.30), PIV (42.17) and SII (67.86) in the cesarean section group were higher than those in the vaginal delivery group (platelet count: 248 103 µ/L, NLR: 0.44, PIV: 80.88 and SII: 91.63). Conclusion: Gender had no effect on systemic inflammatory indices and NLR, PIV, and SII were lower in cesarean delivery in preterm infants born <32 weeks of gestation.

Keywords

Infant , Neutrophil-to-lymphocyte ratio , Pan immune inflammation value , Premature , Systemic immune-inflammation index

Kaynakça

Sangkomkamhang U, Pattanittum P, Laopaiboon M, Lumbiganon P. Mode of delivery and outcomes in preterm births. J Med Assoc Thai. 2011;94:415-20.
Gluck O, Tairy D, Bar J, Barda G. The impact of mode of delivery on neonatal outcome in preterm births. J Matern Fetal Neonatal Med. 2021;34:1183-9.
Schmidt S, Norman M, Misselwitz B, Piedvache A, Huusom LD, Varendi H et al. Mode of delivery and mortality and morbidity for very preterm singleton infants in a breech position: A European cohort study. Eur J Obstet Gynecol Reprod Biol. 2019;234:96-102.
Wu JH, Chou HC, Chen PC, Jeng SF, Chen CY, Tsao PN et al. Impact of delivery mode and gestational age on haematological parameters in Taiwanese preterm infants. J Paediatr Child Healt. 2009;45:332-6.
Townsel CD, Emmer SF, Campbell WA, Hussain N. Gender differences in respiratory morbidity and mortality of preterm neonates. Front Pediatr. 2017;5:6.
Casimir GJ, Duchateau J. Gender differences in inflammatory processes could explain poorer prognosis for males. J Clin Microbiol. 2011;49:478-9.
Lu Y, Zhou S, Dreyer RP, Spatz ES, Geda M, Lorenze NP et al. Sex differences in inflammatory markers and health status among young adults with acute myocardial infarction: results from the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) Study. Circ Cardiovasc Qual Outcomes. 2017;10:e003470.
Bergens O, Nilsson A, Kadi F. Associations between circulating inflammatory biomarkers and indicators of muscle health in older men and women. J Clin Med. 2021;10:5316.
Cartier A, Côté M, Lemieux I, Pérusse L, Tremblay A, Bouchard C et al. Sex differences in inflammatory markers: what is the contribution of visceral adiposity? Am J Clin Nutr. 2009;89:1307-14.
Cairo MS, Wagner EL, Fraser J, Cohen G, van de Ven C, Carter SL et al. Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion. 2005;45:856-66.

Aroviita P, Teramo K, Hiilesmaa V, Kekomäki R. Cord blood hematopoietic progenitor cell concentration and infant sex. Transfusion. 2005;45:613-21.
Cakir E, Ozkocak Turan I. Which hemogram-derived indices might be useful in predicting the clinical outcomes of sepsis patients in the intensive care unit? Cukurova Med J. 2021;46:532-9.
Urbanowicz T, Michalak M, Olasińska-Wiśniewska A, Rodzki M, Witkowska A, Gąsecka A et al. Neutrophil counts, neutrophil-to-lymphocyte ratio, and systemic inflammatory response index (SIRI) predict mortality after off-pump coronary artery bypass surgery. Cells. 2022;11:1124.
Ceran B, Alyamaç Dizdar E, Beşer E, Karaçağlar NB, Sarı FN. Diagnostic role of systemic inflammatory indices in infants with moderate-to-severe hypoxic ischemic encephalopathy. Am J Perinatol. 2021;doi:10.1055/a-1673-1616.
Karabulut B, Arcagök BC, Simsek A. Utility of the platelet-to-lymphocyte ratio in diagnosing and predicting treatment success in preterm neonates with patent ductus arteriosus. Fetal Pediatr Pathol. 2021;40:103-12.
Can E, Hamilcikan Ş, Can C. The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for detecting early-onset neonatal sepsis. J Pediatr Hematol Oncol. 2018;40:e229-e232.
Kurtul BE, Kabatas EU, Zenciroglu A, Ozer PA, Ertugrul GT, Beken S et al. Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity. J AAPOS. 2015;19:327-31.
Stein AA, Eyerly-Webb S, Solomon R, Tani C, Shachar E, Kimball R et al. Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage. Clin Neurol Neurosurg. 2019;180:52-6.
Yang Y, Cao ZL, Zhou XY, Chen XQ, Pan JJ, Cheng R. Does neutrophil/lymphocyte ratio have good diagnostic value in neonatal necrotizing colitis? J Matern Fetal Neonatal Med. 2019;32:3026-33.
Cakir U, Tayman C, Buyuktiryaki M. An unknown risk factor for sepsis in very low birth weight preterms: ABO blood groups (BGaPS Study). Am J Perinatol. 2021;38:669-75.
Özkan H, Erdeve Ö, Kutman HGK. Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment. Turk Pediatri Ars. 2018;53:45-54.
Cakir U, Tayman C, Karacaglar NB, Beser E, Ceran B, Unsal H. Comparison of the effect of continuous and standard intermittent bolus paracetamol infusion on patent ductus arteriosus. Eur J Pediatr. 2021;180:433-40.
Cakir U, Tayman C, Yarci E, Halil H, Buyuktiryaki M, Ulu HO et al. Novel useful markers for follow-up of necrotizing enterocolitis: endocan and interleukin-33. J Matern Fetal Neonatal Med. 2020;33:2333-41.
Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723-9.
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A et al. International Classification of Retinopathy of Prematurity, Third Edition. Ophthalmology. 2021;128:e51-e68.
Volpe JJ. Impaired neurodevelopmental outcome after mild germinal matrix-intraventricular hemorrhage. Pediatrics. 2015;136:1185-7.
Fenton TR, Kim JH. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr. 2013;13:59.
Lin CY, Kwon H, Rangel Rivera GO, Li X, Chung D, Li Z. Sex differences in using systemic inflammatory markers to prognosticate patients with head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2018;27:1176-85.
Shim SY, Cho SJ, Kong KA, Park EA. Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study. Sci Rep. 2017;7:6161.
Fleisher B, Kulovich MV, Hallman M, Gluck L. Lung profile: sex differences in normal pregnancy. Obstet Gynecol. 1985;66:327-30.
Ito M, Tamura M, Namba F; Neonatal Research Network of Japan. Role of sex in morbidity and mortality of very premature neonates. Pediatr Int. 2017;59:898-905.
Lingappan K, Jiang W, Wang L, Moorthy B. Sex-specific differences in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2016;311:L481-93.
Zhang X, Zhang Y, Xu Y, Liu J, Fu M, Ding Y et al. Age- and sex-specific reference intervals for complete blood count parameters in capillary blood for Chinese neonates and infants: A prospective study. Clin Chim Acta. 2023;538:104-12.
Jung E, Romero R, Yeo L, Diaz-Primera R, Marin-Concha J, Para R et al. The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications. Semin Fetal Neonatal Med. 2020;25:101146.
Glasser L, Sutton N, Schmeling M, Machan JT. A comprehensive study of umbilical cord blood cell developmental changes and reference ranges by gestation, gender and mode of delivery. J Perinatol. 2015;35:469-75.
Zitouni S, Bouatrous E, Laabidi O, Boudrigua I, Chaouachi D, Saidani N et al. Tunisian Newborn's Cord Blood: Reference values of complete blood count and hemoglobin fractions. Am J Perinatol. 2022;39:1241-7.
Ronchi F, Porcella A, Porcu PP, Salis S, Locci C, Vacca N et al. Cord blood hematological reference values in term and late preterm infants from the Mediterranean island of Sardinia: a preliminary study. J Pediatr Neonat Individual Med. 2020;10:e100109.
Troianova N, Mariotti B, Micheletti V, Calzetti F, Donini M, Salvagno G et al. Impact of Sex on Circulating Leukocytes Composition in COPD Patients. Int J Chron Obstruct Pulmon Dis. 2021;16:3539-3550.
Faraji J, Bettenson D, Babatunde S, Gangur-Powell T, Yong VW, Metz GAS. Thermoregulatory dynamics reveal sex-specific inflammatory responses to experimental autoimmune encephalomyelitis in mice: Implications for multiple sclerosis-induced fatigue in females. Brain Behav Immun Health. 2022;23:100477.
Cakir U, Tugcu AU, Tayman C, Yildiz D. Evaluation of the effectiveness of systemic inflammatory indices in the diagnosis of respiratory distress syndrome in preterm with gestational age of ≤32 weeks. Am J Perinatol. 2023;doi:10.1055/a-2051-8544.
Cakir U, Tayman C, Tugcu AU, Yildiz D. Role of systemic inflammatory indices in the prediction of moderate to severe bronchopulmonary dysplasia in preterm infants. Arch Bronconeumol. 2023;59:216-22.
Werner EF, Han CS, Savitz DA, Goldshore M, Lipkind HS. Health outcomes for vaginal compared with cesarean delivery of appropriately grown preterm neonates. Obstet Gynecol. 2013;121:1195-1200.
Lubetzky R, Ben-Shachar S, Mimouni FB, Dollberg S. Mode of delivery and neonatal hematocrit. Am J Perinatol. 2000;17:163-5.
Ozyürek E, Cetintaş S, Ceylan T, Oğüş E, Haberal A, Gürakan B et al. Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns. Clin Lab Haematol. 2006;28:97-104.
Redźko S, Przepieść J, Zak J, Urban J, Wysocka J. Influence of perinatal factors on hematological variables in umbilical cord blood. J Perinat Med. 2005;33:42-5.
Sheffer-Mimouni G, Mimouni FB, Lubetzky R, Kupferminc M, Deutsch V, Dollberg S. Labor does not affect the neonatal absolute nucleated red blood cell count. Am J Perinatol. 2003;20:367-71.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Yenidoğan

Bölüm

Araştırma Makalesi

Yazarlar

Ufuk Çakır ^*
0000-0002-9409-185X
Türkiye

Cüneyt Tayman
0000-0002-9970-0714
Türkiye

Yayımlanma Tarihi

29 Aralık 2023

Gönderilme Tarihi

25 Eylül 2023

Kabul Tarihi

12 Aralık 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 48 Sayı: 4

DOI

https://doi.org/10.17826/cumj.1366249

IZ

https://izlik.org/JA43TX28WH

MLA

Çakır, Ufuk, ve Cüneyt Tayman. “Effect of sex and mode of delivery on systemic inflammatory indices in preterm infants”. Cukurova Medical Journal, c. 48, sy 4, Aralık 2023, ss. 1347-56, doi:10.17826/cumj.1366249.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

Öz

Anahtar Kelimeler

Effect of sex and mode of delivery on systemic inflammatory indices in preterm infants

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster