How does being a twin premature infant affect systemic inflammatory indices?
Öz
Purpose: Systemic inflammatory indices are newly defined parameters in diseases in the field of neonatology. However, it is not known whether the levels of systemic inflammatory indices change in twin preterms.
Materials and Methods: Premature infants <32 weeks of gestational age were included in our study. Demographic characteristics, morbidity, mortality, leukocyte, neutrophil, monocyte, lymphocyte, platelet count data of all patients were recorded retrospectively. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune ratio-inflammation index (SII), pan-immune-inflammation value (PIV) and systemic inflammation response index (SIRI) values were calculated. Twins and singleton infants were compared with each other in terms of demographic characteristics, morbidity, mortality, complete blood count parameters and systemic inflammatory indices.
Results: A total of 953 infants, including 200 twins and 753 singleton premature infants, were included in the study. Cesarean section, respiratory distress syndrome, and intraventricular hemorrhage were found to be higher in the twins group compared to the singleton group. The leukocyte, neutrophil, monocyte, lymphocyte count was found to be lower in the twins group and the platelet count was found to be significantly higher in the singleton group. PLR value was higher (41.81 and 32.09, respectively) and PIV value was lower (43.66 and 47.93, respectively) in the twins group compared to the singleton group. NLR, MLR, SII, SIRI values were similar between twins and singleton groups. There was no difference in demographic characteristics, morbidity, mortality, complete blood count parameters and systemic inflammatory indices of the first and the second twin premature infants.
Conclusion: Differences in systemic inflammatory indices and multiple hematological parameters between twins and singleton premature infants should be interpreted carefully taking into account pre/postnatal conditions to understand clinical outcomes.
Anahtar Kelimeler
Systemic inflammatory indices, Infant, Premature, Singleton, Twin
Destekleyen Kurum
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Etik Beyan
Çalışmaya başlamadan önce yerel etik kuruldan etik onay alındı.
Teşekkür
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Kaynakça
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