Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?

Sevgi Karabulut Uzunçakmak; Halil Özcan; Pelin Aydın; Zekai Halıcı

doi:10.17826/cumj.1624159

TR EN

Lrig1 ekspresyonunun şizofrenide ERBB1 ve ERBB2 ekspresyonuyla ilişkisi var mıdır?

Öz

Amaç: Bu çalışmanın amacı şizofrenide Lrig1 ekspresyonunu araştırmak ve şizofrenide Lrig1, ERBB1 ve ERBB2 arasındaki olası ilişkiyi ortaya koymaktır. Gereç ve Yöntem: Çalışmaya 70 şizofreni hastası ve 60 sağlıklı bireye ait periferik kan örneği dahil edildi. Lrig1, ERBB1 ve ERBB2 gen ekspresyon analizi için Real Time PCR kullanıldı. Bulgular: Lrig1 mRNA düzeyi hastalarda sağlıklı kontrollere nispeten düşüktü. ERBB1 ve ERBB2'nin hastalarda sağlıklı kontrollerden daha düşük ifade düzeylerine sahip olduğu görüldü. Alıcı işletim karakteristiği eğrisi analizine göre, üç genin hastaları sağlıklı kontrollerden ayırt etme gücü vardı (Lrig1 AUC: 0,66, p = 0,006, ERBB1 AUC: 0,64 ERBB2 AUC: 0,79). Şizofreni hastalarında Lrig1 ve ERBB1 ifadeleri arasında zayıf, pozitif bir korelasyon vardı. Hastaların gen ifadelerine bakıldığında Lrig1 ile ERBB2 arasında ve ERBB1 ile ERBB2 arasında anlamlı bir korelasyon olmadığı görülmüştür. Sonuç: Sonuçlar Lrig1 ve ERBB ilişkisinin şizofrenide değiştiğini ortaya koydu. Bu genlerin şizofrenide kullanılabilecek bir biyobelirteç olma potansiyeline sahip olduğu düşünülmektedir.

Anahtar Kelimeler

Şizofreni , Lrig1 , ERBB1 , ERBB2 , EGFR

Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?

Abstract

Purpose: This study aims to investigate Lrig1 expression and to reveal the possible relationship between Lrig1, ERBB1 and ERBB2 in schizophrenia. Materials and Methods: In this study, peripheral blood samples of 70 schizophrenia patients and 60 healthy controls were used. Real Time PCR was applied for Lrig1, ERBB1 and ERBB2 gene expression analysis. Results: The level of Lrig1 mRNA was lower in the patients when compared to healthy controls. Expression levels of ERBB1 and ERBB2 were decreased in the patients versus in the healthy controls. According to the receiver operating characteristic curve analysis, the three genes had the power to discriminate the patients from the healthy controls (Lrig1 AUC: 0.66, ERBB1 AUC: 0.64, ERBB2 AUC: 0.79). There was a weak, positive correlation between the Lrig1 and ERBB1 expressions in the schizophrenia patients. No significant correlation was detected between the Lrig1 and ERBB2 expressions or the ERBB1 and ERBB2 expressions in the patients. Conclusion: The results revealed that the Lrig1 and ERBB relationship changes in schizophrenia. These genes may have the potential to be a biomarker that can be used in schizophrenia.

Keywords

Schizophrenia , Lrig1 , ERBB1 , ERBB2 , EGFR

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Psikiyatri , Tıbbi Biyokimya - Nükleik Asitler

Bölüm

Araştırma Makalesi

Yazarlar

Sevgi Karabulut Uzunçakmak ^*
0000-0001-9714-0349
Türkiye

Halil Özcan
0000-0001-7412-7774
Türkiye

Pelin Aydın
0000-0001-7279-7758
Türkiye

Zekai Halıcı
0000-0001-6854-6059
Türkiye

Yayımlanma Tarihi

31 Mart 2025

Gönderilme Tarihi

21 Ocak 2025

Kabul Tarihi

21 Mart 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 50 Sayı: 1

DOI

https://doi.org/10.17826/cumj.1624159

IZ

https://izlik.org/JA72JW47SU

MLA

Karabulut Uzunçakmak, Sevgi, vd. “Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?”. Cukurova Medical Journal, c. 50, sy 1, Mart 2025, ss. 221-30, doi:10.17826/cumj.1624159.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Lrig1 ekspresyonunun şizofrenide ERBB1 ve ERBB2 ekspresyonuyla ilişkisi var mıdır?

Öz

Anahtar Kelimeler

Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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