Role of medication adherence in the relationship between neuroticism and functioning in patients with bipolar disorder

Hasan Bakay; Mukaddes Funda Şahin

doi:10.17826/cumj.1795623

EN TR

Role of medication adherence in the relationship between neuroticism and functioning in patients with bipolar disorder

Abstract

Purpose: This study examined the relationship between neuroticism, medication adherence, and functioning in Bipolar disorder (BD) patients. Furthermore, the role of medication adherence as a mediator between neuroticism and functioning was investigated. Materials and Methods: The study included 71 patients with BD and 44 healthy controls. All participants were assessed using the Eysenck Personality Inventory (EPI), Brief Functional Assessment Scale (FAST), and Medication Adherence Rating Scale (MARS). Anxiety and depression levels were assessed using the Hamilton Anxiety (HAM-A) and Depression (HAM-D) Rating Scales. Results: Patients with bipolar disorder showed higher neuroticism scores compared with healthy controls (mean 2.61 vs. 1.66) and poorer functioning (FAST: 13.70 vs. 7.74). Within the patient group, neuroticism was moderately associated with worse functioning (r = .43) and lower medication adherence (r = –.28). Medication adherence showed a strong association with better functioning (r = –.50). In the mediation analysis, higher neuroticism predicted lower adherence (standardized β = –0.29), and lower adherence predicted poorer functioning (β = –0.35), indicating a significant indirect pathway from neuroticism to functional impairment through medication adherence. Conclusion: Neuroticism negatively affects the functioning of patients with BD through poor medication adherence. Thus, personality traits should be considered when planning treatments aimed at improving functioning in patients with BD. Interventions aimed at increasing medication adherence in patients with high levels of neuroticism may lead to better functioning-related outcomes.

Keywords

Bipolar disorder , functionality , medication adherence , neuroticism , personality

Bipolar bozuklukta nevrotiklik ve işlevsellik arasındaki ilişkide ilaç uyumunun rolü

Öz

Amaç: Bu çalışmada, Bipolar bozukluk (BB) tanılı bireylerde nevrotiklik, ilaç uyumu ve işlevsellik arasındaki ilişkilerin incelenmesi amaçlanmıştır. Ek olarak, ilaç uyumunun nevrotiklik ile işlevsellik arasındaki ilişkide aracı rolü araştırılmıştır. Gereç ve Yöntem: Bu çalışmaya 44 sağlıklı kontrol ile birlikte 71 BB hastası dahil edilmiştir. Katılımcılara Eysenck Kişilik Envanteri (EKE), Kısa İşlevsellik Değerlendirme Testi (KİDT) ve İlaç Uyum Derecelendirme Ölçeği (İUDÖ) uygulanmıştır. Anksiyete ve depresyon düzeyleri Hamilton Anksiyete (HAM-A) ve Depresyon (HAM-D) Derecelendirme Ölçekleri ile değerlendirilmiştir. Bulgular: BB hastaları, sağlıklı kontrollere kıyasla daha yüksek nevrotiklik puanlarına (ort. 2.,61 vs. 1.,66) ve daha kötü işlevselliğe (KİDT: 13.,70 vs. 7.,74) sahipti. Hasta grubunda nevrotiklik, işlevsellik ile orta düzeyde pozitif (r=.,43) ve ilaç uyumu ile negatif yönde ilişkiliydi (r=–.,28). İlaç uyumu, daha iyi işlevsellik ile güçlü bir ilişki gösterdi (r=–.,50). Mediyasyon analizinde yüksek nevrotikliğin daha düşük ilaç uyumunu yordadığı (standart β=–0.,29) ve düşük uyumun daha kötü işlevsellik ile ilişkili olduğu (β=–0.,35) görüldü; bu bulgular, nevrotiklik ile işlevsellik arasındaki ilişkinin ilaç uyumu üzerinden dolaylı olarak gerçekleştiğini gösterdi. Sonuç: Nevrotiklik, BB’de işlevselliği olumsuz etkilemekte ve bu etki düşük ilaç uyumu aracılığıyla dolaylı olarak ortaya çıkmaktadır. Bulgularımız, BB’de işlevselliği artırmaya yönelik tedavi planlamasında kişilik özelliklerinin dikkate alınması gerektiğini göstermektedir. Yüksek nevrotiklik düzeyine sahip hastalarda ilaç uyumunu artırmaya yönelik müdahalelerin işlevsellikle ilgili sonuçları olumlu etkileyebilir.

Anahtar Kelimeler

Bipolar bozukluk , ilaç uyumu , işlevsellik , kişilik , nevrotiklik

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Psikiyatri

Bölüm

Araştırma Makalesi

Yazarlar

Hasan Bakay ^*
0000-0002-8864-2942
Türkiye

Mukaddes Funda Şahin
0009-0004-7601-7025
Türkiye

Yayımlanma Tarihi

22 Aralık 2025

Gönderilme Tarihi

2 Ekim 2025

Kabul Tarihi

10 Aralık 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 50 Sayı: 4

DOI

https://doi.org/10.17826/cumj.1795623

IZ

https://izlik.org/JA43TJ38YC

MLA

Bakay, Hasan, ve Mukaddes Funda Şahin. “Role of medication adherence in the relationship between neuroticism and functioning in patients with bipolar disorder”. Cukurova Medical Journal, c. 50, sy 4, Aralık 2025, ss. 1123-34, doi:10.17826/cumj.1795623.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Role of medication adherence in the relationship between neuroticism and functioning in patients with bipolar disorder

Abstract

Keywords

Bipolar bozuklukta nevrotiklik ve işlevsellik arasındaki ilişkide ilaç uyumunun rolü

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster