Araştırma Makalesi

Pulmoner tromboemboli hastalarında ortalama trombosit hacmindeki değişiklikler

Cilt: 41 Sayı: 3 30 Eylül 2016
Murat Memiş , Gülhan Kurtoğlu Çelik , Alp Şener , Havva Şahin Kavaklı , Ferhat İçme , Onur Karakayalı , Halil Yıldırım
PDF İndir
EN TR

Changes in mean platelet volume values in patients with pulmonary thromboembolism

Abstract

Purpose: This clinical study aimed at determining whether mean platelet volume values were useful in predicting embolic load by comparing the values of patients diagnosed with pulmonary thromboembolism with pulmonary arterial computed tomography obstruction index.

Material and Methods: This retrospective study enrolled 120 inpatients with pulmonary thromboembolism diagnosis in emergency service. Patients’ mean platelet volume, Troponin-I, D-dimer values, arterial blood gases, chest radiographs, electrocardiograms, echocardiograms and venous doppler ultrasound findings were recorded. Moreover, pulmonary arterial computed tomography obstruction index for each case was calculated by extracting data from patients’ computed tomography angiographies.

Results: There was a statistically significant difference particularly between pulmonary arterial computed tomography obstruction index values of the cases having mean platelet volume value < 8.5fl and mean platelet volume value > 8.5fl (25.0 and 45.0). Pulmonary arterial pressure of the group with mean platelet volume level > 8.5 was found significantly higher compared to the group with mean platelet volume level < 8.5fl.

Conclusions: Usefulness of correlation between mean platelet volume and pulmonary arterial computed tomography obstruction index in assessing the severity of embolism is unclear.


Keywords

Pulmoner embolizm,ortalama trombosit hacmi

Kaynakça

  1. Yung GL, Fedullo PF. Pulmonary Thromboembolic Disease. In Fishmans Pulmonary Diseases and Disorders, 4th ed (Eds AP Fishman, JA Elias, JA Fishman, MA Grippi, RM Senior, AI Pack):1423-47. New York, Mc Graw Hill, 2008.
  2. Stein PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest. 1995;108:978-81.
  3. Altintop L, Yardan T, Cander B, Fındık S, Yılmaz O. An increase of BNP levels in massive pulmonary embolism and the reduction in response to the acute treatment. Resuscitation. 2005;65:225–9.
  4. Blachere H, Latrabe V, Montaudon M, Valli N, Couffinhal T, Raherisson C et al. Pulmonary embolism revealed on helical CT angiography: comparison with ventilation-perfusion radionuclide lung 2000;174:1041–7. Am J Roentgenol
  5. Dow RB. The clinical and laboratory utility of trombosit volume parameters. J Med Sci. 1994;15:1- 15.
  6. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-61.
  7. Thompson CB, Jakubowski JA, Quinn PG, Deykin D, Valeri CR. Platelet size as a determinant of platelet function. J Lab Clin Med. 1983;101:205-13.
  8. Trowbridge EA, Martin JF. The platelet volume distribution: a signature of the prethrombotic state in coronary heart disease. Thromb Haemost. 1987;58:714-7.
  9. Li D, Turner A, Sinclair AJ. Relationship between trombosit phospholipid FA and mean platelet volume in healthy men. Lipids. 2002;37:901-6.
  10. Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991;338:1409-11.

Kaynak Göster

MLA
Memiş, Murat, vd. “Changes in mean platelet volume values in patients with pulmonary thromboembolism”. Cukurova Medical Journal, c. 41, sy 3, Eylül 2016, ss. 498-03, doi:10.17826/cukmedj.237502.