Retrospective evaluation of pediatric inpatients admitted with thrombosis according to risk factors: single center experience
Öz
Purpose: Thrombosis in children is a multifactorial disorder associated with both genetic and acquired factors. Idiopathic thrombosis is a rare condition. This study aimed to examine the etiology and risk factors of thrombosis in pediatric patients followed at Baskent University Adana Teaching and Research Center, a reference hospital in the southern part of Turkey.
Material and Methods: This study included a sample of 49 pediatric patients who were retrospectively evaluated. The patient records were examined retrospectively in terms of age at diagnosis with thrombosis, gender, family history of thrombosis, localization of thrombosis, underlying primary disease and presence of catheter, as well as indicators of genetic risk factors.
Results: The number of children presenting to our clinic during the study period was 10358. The incidence of thrombosis was calculated as 49 cases in 10358 children. The median age of the patients was 5.1 years (ranging from 0 to 17.2 years), and there were 32 (65.3%) males. In the analysis of the genetic factors causing susceptibility to primary thrombosis, only a portion of the patients were studied for genetic mutations. Among these, 5 patients showed factor V Leiden mutation, 13 patients MTHFR 1298C mutation, and 18 patients MTHFR 677CT mutation. Seven patients were found have a combination of multiple mutations. When we investigated any possible correlation between high lipoprotein (a) levels and the distribution of mutations, we found that 7 patients with mutations had normal levels of high lipoprotein (a), while other 10 patients with mutations were found to have elevated levels of lipoprotein (a).
Conclusion: We conclude and strongly emphasize that lipoprotein (a) elevation is one of the important genetic risk factors, which might prove a major risk indicator, as valuable as other mutation screening tests performed by molecular genetics
Anahtar Kelimeler
Kaynakça
- REFERENCES
- Zahuranec DB, Brown DL, Lisabeth LD, Morgenstern LB. Is it time for a large, collaborative study of pediatric stroke? Stroke. 2005;36:1825-9
- Lanzkowsky P. Thrombotic disorders. In Manual of Pediatric Hematology and Oncology, 3rd. ed (Ed P Lanzkowsky):233-87. San Diego, Academic Press. 2000.
- Goodnight SH, Griffin JH. Hereditary Trombophilia. In Willams Hematology, 6th ed (Eds E Beutler, MA Lichtman, BS Coller, TJ Kipps, U Seligsohn):1697-707. Baltimore, McGraw-Hill, 2001
- Andrew M, David M, Adams M, Ali K, Anderson R, Barnard D et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood. 1994;83:125-7
- Monagle P, Andrew M. Acquired disorders of hemostasis. In Nathan and Oski’s Hematology of Infancy and Childhood 6th ed (DG Nathan, SH Orkin, D Ginsburg, AT Look): 1631-67. Pennsylvania, Saunders. 2003.
- Gürgey A, Aslan D. Outcome of noncatheter–related thrombosis in children: influence of underlying or coexisting factors. J Pediatr Hematol Oncol. 2001;23:159-64
- Ozbek N, Alioglu B, Avci Z, Malbora B, Onay O, Ozyurek E. Incidence of and risk factors for childhood thrombosis: a single-center experience in Ankara, Turkey. Pediatr Hematol Oncol. 2009;26:1129
- van Ommen CH, Heijboer H, Buller HR, Hirasing RA, Heijmans HS, Peters M. Venous thromboembolism in childhood: a prospective twoyear registry in the Netherlands. J Pediatr. 2001;139:676–81.
- Bauer KA. Inherited disorders of thrombosis and fibrinolysis. In Nathan and Oski’s Hematology of Infancy and Childhood 6th ed (DG Nathan, SH Orkin, D Ginsburg, AT Look):1583-96. Pennsylvania, Saunders. 2003.
