Mania associated with cycloserine
Öz
Cycloserine is a broad
spectrum antibiotic agent commonly used as a second-line treatment for patients
with multi-drug resistant pulmonary and extrapulmonary tuberculosis and
associated with many neuropsychiatric adverse events. Mania is rarely reported
in this context. We report a case of 38-year-old male diagnosed as Pott disease
and developed manic symptoms while on second line anti-tubercular treatment for
multi-drug resistant pulmonary and extrapulmonary tuberculosis. We related
these manic symptoms with cycloserine.
The patient remitted significantly in one week period after
discontinuation of cycloserine and initiation of antipsychotic treatment. This
case emphasizes that manic switch or exacerbation of psychosis can occur in
early or late stage of treatment and that the necessity of periodic psychiatric
evaluation before and during the treatment.
Anahtar Kelimeler
Kaynakça
- 1. Vega P, Sweetland A, Acha J, Castillo H, Guerra D, Smith Fawzi MC et al. Psychiatric issues in the management of patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2004;8:749-59.
