Role of CD4+ regulatory T cells in multiple myeloma

Deniz Ekinci; Aysun Özkan

doi:10.17826/cutf.323972

TR EN

Multipl miyelom’da CD4+ regülatör T hücrelerin rolü

Öz

Yapılan pek çok araştırmada hem yeni tanı multipl miyelomda hem de otolog kök hücre nakli dahil kemoterapötik tedaviler sonrası hastalarda regülatör T hücrelerin artışı söz konusudur. Multipl miyelom habis bir plazma hücre hastalığıdır. Regülatör T hücreleri kanser ve inflamatuar koşullardan otoimmün hastalıklara kadar immün homeostazide rol oynar. PD-1 yolağı yardımcı T hücre popülasyonunu regülatör T hücre gelişimi yönünde uyarmaktadır. PDL1'in indüklenebilir regülatör T hücrelerin farklılaştırılmasında önemli bir rol oynadığı gösterilmiştir. Son zamanlarda multipl miyelomda PDL1 veya PD-1'i hedef alan en az altı klinik çalışma başlatılmıştır. Mevcut literatüre göre miyelom hastalarının anti PD-1/PDL1 tedavisinden fayda sağlayabileceğini önermekteyiz.

Anahtar Kelimeler

PD-1/PDL1-PDL2,Multipl miyelom,regülatör T hücreler,PD-1/PDL1-PDL2

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Deniz Ekinci Bu kişi benim

Aysun Özkan

Yayımlanma Tarihi

30 Eylül 2017

Gönderilme Tarihi

8 Şubat 2107

Kabul Tarihi

16 Mart 2017

Yayımlandığı Sayı

Yıl 2017 Cilt: 42 Sayı: 3

DOI

https://doi.org/10.17826/cutf.323972

IZ

https://izlik.org/JA36CJ35KP

APA

Ekinci, D., & Özkan, A. (2017). Role of CD4+ regulatory T cells in multiple myeloma. Cukurova Medical Journal, 42(3), 546-551. https://doi.org/10.17826/cutf.323972

AMA

1.Ekinci D, Özkan A. Role of CD4+ regulatory T cells in multiple myeloma. Cukurova Med J. 2017;42(3):546-551. doi:10.17826/cutf.323972

Chicago

Ekinci, Deniz, ve Aysun Özkan. 2017. “Role of CD4+ regulatory T cells in multiple myeloma”. Cukurova Medical Journal 42 (3): 546-51. https://doi.org/10.17826/cutf.323972.

EndNote

Ekinci D, Özkan A (01 Eylül 2017) Role of CD4+ regulatory T cells in multiple myeloma. Cukurova Medical Journal 42 3 546–551.

IEEE

[1]D. Ekinci ve A. Özkan, “Role of CD4+ regulatory T cells in multiple myeloma”, Cukurova Med J, c. 42, sy 3, ss. 546–551, Eyl. 2017, doi: 10.17826/cutf.323972.

ISNAD

Ekinci, Deniz - Özkan, Aysun. “Role of CD4+ regulatory T cells in multiple myeloma”. Cukurova Medical Journal 42/3 (01 Eylül 2017): 546-551. https://doi.org/10.17826/cutf.323972.

JAMA

1.Ekinci D, Özkan A. Role of CD4+ regulatory T cells in multiple myeloma. Cukurova Med J. 2017;42:546–551.

MLA

Ekinci, Deniz, ve Aysun Özkan. “Role of CD4+ regulatory T cells in multiple myeloma”. Cukurova Medical Journal, c. 42, sy 3, Eylül 2017, ss. 546-51, doi:10.17826/cutf.323972.

Vancouver

1.Deniz Ekinci, Aysun Özkan. Role of CD4+ regulatory T cells in multiple myeloma. Cukurova Med J. 01 Eylül 2017;42(3):546-51. doi:10.17826/cutf.323972

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Multipl miyelom’da CD4+ regülatör T hücrelerin rolü

Öz

Anahtar Kelimeler