T helper, cytotoxic T, and natural killer T cell profiles and their association with clinical prognosis in children with sickle cell anemia
Abstract
Purpose: Our aim was to determine the effects of ischemic attacks on T cell profiles, immune functions and clinical prognosis in patients with sickle cell anemia. Materials and Methods: The study group consisted of 29 sickle cell anemia patients who were either in vaso-occlusive crisis or in steady state. Twenty-four age-matched healthy children served as the control group. All patients underwent complete blood cell count, hemoglobin electrophoresis, and blood chemistry analysis. Flow-cytometry was used to assess the T-cell profiles. Results: The mean HbS in sickle cell anemia patients during vaso-occlusive crisis was 83±6.6%. The CD3 levels of patients in vaso-occlusive crisis (62.31±7.79%) were lower compared to steady state (65.53±5.72 %) and healthy controls (69.09±9.18%). The NK T cell percentages of patients in vaso-occlusive crisis (13.07±7.67%) were higher than the control group (8.11±4.67%). Conclusion: Total T lymphocyte levels were found to be significantly lower in sickle cell anemia patients during vaso-occlusive crisis compared to healthy controls. NK T cell levels of the study group were higher than that of the control group.
Keywords
children , natural killer t cells , sickle cell anemia , T cell profile , vaso-occlusive crises
Kaynakça
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