Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri

Yurday Özdemir; Neşe Torun; Erkan Topkan

doi:10.17826/cumj.453287

EN TR

The role of PET-CT in the evaluation of the response of the vertebra metastases in stereotactic radiosurgery

Öz

Purpose: The aim of this study was to evaluate the role of positron emission tomography in assessing the response of stereotactic radiosurgery (SRS) for vertebral metastases (VM).

Materials and Methods: Patients who received 16 Gy or 18 Gy SRS with no history of vertebral compression fracture, proven histologies except small-cell lung carcinoma and hematologic malignancies which are known as radiosensitive tumors, available pre- and post SRS PET images were included. All vertebral segments were categorized according to spinal instability neoplastic score in terms of stability and PET Response Criteria in Solid Tumors (PERCIST) criteria was utilized for treatment response.

Results: Seventy-five patients with 119 VS (101 single, 9 double VS) received SRS. Breast cancer (66.7%) was the commonest pathology. Most patients (70.6%) had SINS 0-6. The local control was achieved in 87.4% VS with a 1-year local relapse-free survival rate of 92.5%. The median PET-CT time for the first SRS response assessment was 3 months (range:1-35 months) and there were only 4 (3.3%) local relapses in contrast to the positive responses in the remainders (30.3% complete, 43.7% partial responses and 22.7% stabil disease). While there were 11 local relapses in the last PET-CT response, no patient experienced any relapse complete response was achieved in the first PET-CT. Complete response in the first PET-CT was correlated with positive response in the last PET–CT also.

Conclusion: First PET-CT response after SRS seems to be valuable in anticipation of both the final vertebral response status and planning of alternative interventions for non-responders.

Anahtar Kelimeler

stereotactic radiosurgery,PET-CT response,vertebral metastases

Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri

Öz

Amaç: Bu çalışmada vertebra metastazlarında stereotaktik radyocerrahi (SRC) sonrası yanıt değerlendirmesinde pozitron emisyon tomografisinin (PET-BT) rolü araştırılmıştır.

Gereç ve Yöntem: Geriye dönük olarak 16 veya 18 Gy SRC uygulanmış hastalar incelenmiştir. Analizlere SRC öncesinde herhangi bir derecede vertebra kompresyon kırığı gelişmemiş, radyosensitif olarak bilinen küçük hücreli akciğer ve hematolojik kanserlerli olgular dışındaki tedavi öncesi ve sonrası PET-BT verileri olan hastalar dâhil edilmiştir. Tüm vertebra segmentleri stabilite açısından spinal instability neoplastic score ’e göre sınıflandırılmış ve yanıt değerlendirmesinde PET Response Criteria in Solid Tumors (PERCIST) kriterleri kullanılmıştır.

Bulgular: Toplam 75 hasta 119 VS’e (101 tek, 9 çift) SRC uygulanmış olup büyük kısmını (%66,7) meme kanserli hastalar oluşturmaktadır. VS’lerin %70,6’sı SINS 0-6’ya uymaktadır. Lokal kontrol hastaların %87,4’nde sağlanmış olup 1 yıllık lokal nükssüz sağkalım oranı %92,5 olarak bulunmuştur. İlk yanıt değerlendirme PET-BT’si ortanca 3 ayda (aralık: 1-35 ay) çekilmiş olup sadece 4 (%3.3) VS’de progresyon raporlanırken diğer VS’lerde SRC’ye yanıt mevcuttur (%30.3 tam, %43.7 kısmi, %22.7 stabil). Son PET’de sadece 11 VS’de lokal nüks tespit edilirken ilk PET’de tam yanıt olan hiçbir VS’de nihai olarak lokal nüks gelişmemiştir. İlk PET’de tam yanıt olması son PET’de de yanıt olmasıyla ilişkili bulunmuştur.

Sonuç: SRC sonrası yanıt değerlendirmesinde ilk PET-BT yanıtı gerek son kontrol durumunu göstermesi açısından gerekse alternatif tedavileri planlamak açısından değerli bulunmuştur.

Anahtar Kelimeler

stereotaktik radyocerrahi,PET-BT cevap,vertabral metastaz

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Yurday Özdemir ^*
0000-0002-2218-2074
Türkiye

Neşe Torun
0000-0002-5597-676X
Türkiye

Erkan Topkan
0000-0001-8120-7123
Türkiye

Yayımlanma Tarihi

31 Mart 2019

Gönderilme Tarihi

13 Ağustos 2018

Kabul Tarihi

8 Ekim 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 44 Sayı: 1

DOI

https://doi.org/10.17826/cumj.453287

IZ

https://izlik.org/JA74JS45EL

APA

Özdemir, Y., Torun, N., & Topkan, E. (2019). Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri. Cukurova Medical Journal, 44(1), 206-214. https://doi.org/10.17826/cumj.453287

AMA

1.Özdemir Y, Torun N, Topkan E. Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri. Cukurova Med J. 2019;44(1):206-214. doi:10.17826/cumj.453287

Chicago

Özdemir, Yurday, Neşe Torun, ve Erkan Topkan. 2019. “Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri”. Cukurova Medical Journal 44 (1): 206-14. https://doi.org/10.17826/cumj.453287.

EndNote

Özdemir Y, Torun N, Topkan E (01 Mart 2019) Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri. Cukurova Medical Journal 44 1 206–214.

IEEE

[1]Y. Özdemir, N. Torun, ve E. Topkan, “Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri”, Cukurova Med J, c. 44, sy 1, ss. 206–214, Mar. 2019, doi: 10.17826/cumj.453287.

ISNAD

Özdemir, Yurday - Torun, Neşe - Topkan, Erkan. “Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri”. Cukurova Medical Journal 44/1 (01 Mart 2019): 206-214. https://doi.org/10.17826/cumj.453287.

JAMA

1.Özdemir Y, Torun N, Topkan E. Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri. Cukurova Med J. 2019;44:206–214.

MLA

Özdemir, Yurday, vd. “Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri”. Cukurova Medical Journal, c. 44, sy 1, Mart 2019, ss. 206-14, doi:10.17826/cumj.453287.

Vancouver

1.Yurday Özdemir, Neşe Torun, Erkan Topkan. Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri. Cukurova Med J. 01 Mart 2019;44(1):206-14. doi:10.17826/cumj.453287

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The role of PET-CT in the evaluation of the response of the vertebra metastases in stereotactic radiosurgery

Öz

Anahtar Kelimeler

Stereotaktik radyocerrahi uygulanan vertebra metastazlarında yanıt değerlendirmesinde PET-BT’nin yeri

Öz

Anahtar Kelimeler

Kaynakça

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Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

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Yayımlandığı Sayı

DOI

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