NF-Kappa B expression in pancreatic ductal carcinoma

Deniz Tunçel; N. Ümit Bayol

doi:10.17826/cumj.481396

TR EN

NF-Kappa B expression in pancreatic ductal carcinoma

Öz

Purpose: In this study we investigated the expression of the p65 subunit of the nuclear factor-kappaB (NF-kB) complex and the activation status of NF-kB by phospho-IkB-alpha antibody.

Materials and Methods: A tissue microarray based on material obtained from 107 patients was utilized. The antibody staining was scored by combining staining intensity with percentage of tumor staining. The antibodies used were NF-kB p65 and phospho-IkB-alpha(ser32/36), both from Cell Signaling Technology. The staining scores were correlated with the archival data available on some patients on margin and lymph node status, stage, tumor size, as well as clinical data including survival.

Results: The staining was nuclear (p65) and cytoplasmic (p-IkBalpha) respectively. In general there was an increased expression and activation of NF-kB in the carcinomas, compared to non-tumoral regions. None of the markers had a significant correlation with the overall survival. NF-kB(p65) expression had a correlation with positive lymph node status.

Conclusion: The correlation with the positive lymph node status suggests a role in invasive properties of the tumor. Activation of NF-kB is most likely an early event in pancreatic carcinogenesis. Despite the lack of an effect on overall survival, due to its increased activation in pancreatic cancer, NF-kB is still a good target for therapeutic interventions.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Deniz Tunçel ^*
0000-0001-6025-9733
Türkiye

N. Ümit Bayol Bu kişi benim
0000-0002-7424-5268
Türkiye

Yayımlanma Tarihi

30 Haziran 2019

Gönderilme Tarihi

11 Kasım 2018

Kabul Tarihi

14 Aralık 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 44 Sayı: 2

DOI

https://doi.org/10.17826/cumj.481396

IZ

https://izlik.org/JA33HW59GG

APA

Tunçel, D., & Bayol, N. Ü. (2019). NF-Kappa B expression in pancreatic ductal carcinoma. Cukurova Medical Journal, 44(2), 494-501. https://doi.org/10.17826/cumj.481396

AMA

1.Tunçel D, Bayol NÜ. NF-Kappa B expression in pancreatic ductal carcinoma. Cukurova Med J. 2019;44(2):494-501. doi:10.17826/cumj.481396

Chicago

Tunçel, Deniz, ve N. Ümit Bayol. 2019. “NF-Kappa B expression in pancreatic ductal carcinoma”. Cukurova Medical Journal 44 (2): 494-501. https://doi.org/10.17826/cumj.481396.

EndNote

Tunçel D, Bayol NÜ (01 Haziran 2019) NF-Kappa B expression in pancreatic ductal carcinoma. Cukurova Medical Journal 44 2 494–501.

IEEE

[1]D. Tunçel ve N. Ü. Bayol, “NF-Kappa B expression in pancreatic ductal carcinoma”, Cukurova Med J, c. 44, sy 2, ss. 494–501, Haz. 2019, doi: 10.17826/cumj.481396.

ISNAD

Tunçel, Deniz - Bayol, N. Ümit. “NF-Kappa B expression in pancreatic ductal carcinoma”. Cukurova Medical Journal 44/2 (01 Haziran 2019): 494-501. https://doi.org/10.17826/cumj.481396.

JAMA

1.Tunçel D, Bayol NÜ. NF-Kappa B expression in pancreatic ductal carcinoma. Cukurova Med J. 2019;44:494–501.

MLA

Tunçel, Deniz, ve N. Ümit Bayol. “NF-Kappa B expression in pancreatic ductal carcinoma”. Cukurova Medical Journal, c. 44, sy 2, Haziran 2019, ss. 494-01, doi:10.17826/cumj.481396.

Vancouver

1.Deniz Tunçel, N. Ümit Bayol. NF-Kappa B expression in pancreatic ductal carcinoma. Cukurova Med J. 01 Haziran 2019;44(2):494-501. doi:10.17826/cumj.481396

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NF-Kappa B expression in pancreatic ductal carcinoma

Pankreas duktal adenokarsinomunda NF-Kappa B ekspresyonu

Öz

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NF-Kappa B expression in pancreatic ductal carcinoma

Öz

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