İleri Evre Renal Hücreli Karsinomlu Pediatrik Vakanın Başarılı Tedavisi
Öz
Renal hücreli karsinomun çocukluk çağındaki tedavisi esas olarak geniş cerrahi rezeksiyon ile yapılmaktadır. Çoğu evre I-II vaka için radikal nefrektomi ve lenf nodu diseksiyonu yeterli olurken ileri evrelerde immünoterapinin de dahil olduğu farklı tedavi yöntemleri tanımlanmıştır. Burada tanı anında opere edilemeyen, sonrasında interferon alfa ile başarılı bir şekilde tedavi edilen ileri evre renal hücreli karsinomu olan 9 yaşında bir kız sunulmuştur.
Anahtar Kelimeler
Kaynakça
- Age (yr.s)/sex Stage Chemotherapy Radiotherapy Interferon/ (mo.s) Outcome 2 3/M 4 ACT-D No Yes/? NED, 14 years 2 14/F 4 5-FU No Yes/? Died, 0.3 years 2 10/F 4 No No Yes/? Died, 5 years 4 9/M 3 No No Yes/72 NED, 7 years 4 6/M 3 No No Yes/36 Lung met., 3 years 5 13/F 3 V+ ACT-D No Yes/6 Died, 2 years 5 9/F 3 V No Yes/12 NED, 5 years Present case 9/F 3 Cis+Dac No Yes/36 NED, 5 years V: Vincristin, Cis+Dac: Cisplatin+Dacarbazine, ACT-D: Actinomycin-D, 5-FU: 5-Fluorouracil, NED: No evidence of disease, met: metastasis Since the patient tolerated IFN α well with a dose of 3 million IU/m 2 five days in a week, we administered it for one year, followed by 3 million IU/m 2 two times/week for another one year and once a week for the last year. Although the complete surgical resection has utmost importance in treatment, based on our experience on the presented case, adjuvant use of IFN α treatment can be considered in patients with locally advanced RCC who are under the risk of recurrence. Being a rare disease, the role of adjuvant therapies in pediatric RCC, including IFN α needs to be investigated in multicentric randomised studies. and a review of literature. J Surg Oncol. 2000; 75:266-9.
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