Comparison of Intravenous Paracetamol and Tramadol in Children Undergoing Major Abdominal Surgery
Abstract
Purpose: Postoperative pain and pain related hemodynamic instability are frequently observed problems in children undergoing major abdominal surgery. In our study, we aimed to comparison of the effect intravenous paracetamol and tramadol on postoperative analgesia and tramadol consumption. Material and Methods: After approval of faculty ethical committee and parents consent, 90 children aged 3-14 years undergoing major abdominal surgery were included in this study. Patients randomly divided into two groups. Forty five minutes before the end of surgery, Group P patients were given intravenously paracetamol (15 mg/kg, in 15 minutes) and Group T patients were given intravenously tramadol(1 mg/kg). Parent controlled analgesia with tramadol (bolus dose 0.2 mg/kg, lock out 20 minutes) was started in both groups. Postoperatively, patients’ systolic and diastolic blood pressures, heart rates, oxygen saturation values, pain scores, total tramadol consumption and side effects were recorded. Results: Demographic data, duration of surgery and hemodynamic parameters were similar between the groups. Total tramadol consumption were recorded 76.11 ± 105.65 mg in Group P and 83.50 ± 97.35 mg in Group T for 24 hours(p>0.05). There was not any significantly difference in side effects and pain scores between the groups (p > 0.05). Conclusion: It was concluded that, intravenous paracetamol was provided effective analgesia but it was not superior to intravenous tramadol in children undergoing major abdominal surgery.
Keywords
Children, parent controlled analgesia, paracetamol, postoperative pain, tramadol
Kaynakça
- Ferrante FM, Vadeboncoeur TR. Postoperative Pain Management. 2nd Ed., New York: Churchill Livingstone Inc. 1993:485-518.
- Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43:879-923.
- Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs. 2000;60:139-76.
- Bonnefont J. Courade JP, Alloui A, Eschalier A. Mechanism of the antinociceptive effect of 15. Arana A, Morton NS, Hansen TG. Treatment with paracetamol. Drugs. 2003;63:1-4.
- Mitchell RWD, Smith G. The control of acute postoperative pain. Br J Anaesth. 1989;63:147-8.
- Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg. 2002;183:630- 41.
- Czarnecki ML, Hainsworth K, Simpson PM, Arca MJ, Uhing MR, Varadarajan J, et al Weisman SJ. Is there an alternative to continuous opioid infusion for neonatal pain control? A preliminary report of parent/nurse-controlled analgesia in the neonatal intensive care unit. Paediatr Anaesth. 2014;24:377- 85.
- Lehman KA. Tramadol for the management of acute pain .Drugs. 1994;47:19-32.
- Özyalçın S, Yücel A, Erdine S. Postoperatif
- analjezide tramadol, petidin, morfin ve fentanil ile iv PCA. Türk Anesteziyoloji ve Reanimasyon Mecmuası. 1997;25:207-13.
