Chronic Myeloid Leukemia In a Pregnant Woman: A Case Report

Cilt: 40 Sayı: 4 5 Ekim 2015
Aytekin Tokmak , Ali Güzel , Ahmet Yalınkaya
PDF İndir
EN TR

Chronic Myeloid Leukemia In a Pregnant Woman: A Case Report

Abstract

Chronic myeloid leukemia (CML) is a rare disease in pregnancy. Our aim is to present a 37 weeks of pregnant woman with chronic myelogenous leukemia. A 27 Years in multigravi (gravida 5, parity: 4), at 37 weeks gestation was admitted with the diagnosis of painful pregnancy and CML. Physical examination findings were normal, complete blood count and peripheral blood smear results were consistent with CML. The patient was diagnosed CML in the 30th week of pregnancy and were treated with hydroxyurea and interferon. Treatment depends on the mother and the fetus did not develop any side effects. Our patient with CML is interesting due to lack of perinatal effects and take the diagnosis at an early age. CML diagnosed during pregnancy requires a multidisciplinary approach and hydroxyurea and interferon treatment on the mother and fetus are at low risk of inducing adverse effects.

Keywords

CML, pregnancy, hydroxyurea, interferon

Kaynakça

  1. Faderl S, Talpaz M, Estrov Z, Kantarjian HM. Chronic myelogenousleukemia: biology and therapy. Ann Intern Med 1999;131:207–19.
  2. Mughal TI, Goldman JM. Chronic myeloid leukaemia: STI 571 magnifiesthe therapeutic dilemma. Eur J Cancer. 2001;37:561–8.
  3. Lichtman M, Leisveld J. Acute myelogenous leukemia. In: Beutler E,Lichtman M,Coller B et al (Eds). Williams Hematology (ed 6). New York, NY,McGraw-Hill 2001:1047-84.
  4. Zuazu J, Julia A, Sierra J et al. Pregnancy outcome in hematologic malignencies. Cancer. 1991;67:703-9.
  5. Mclain CR. Leukemia in pregnancy. Clin Obstet Gynec. 1974;17:185-94.
  6. Buekers TE, Lallas TA. Chemotherapy in pregnancy. Obstet Gynecol ClinNorth Am. 1998;25:323–9.
  7. Celiloglu M, Altunyurt S, Undar B. Hydroxyurea treatment for chronic myeloid leukemia during pregnancy. 2000;79:803-4
  8. Reichel RP, Linkesch W, Schetitska D. Therapy with recombinant interferon alpha-2c during unexpected pregnancy in a patient with chronic myeloid leukaemia. Br J Haematol. 1992;82:472–8.
  9. YadavU, Solanki SL, Yadav R. Chronic myeloid leukemia with pregnancy: Successful management of pregnancy and delivery with hydroxyureaand imatinib continued 2013;9:484-6. doi: 10.4103/0973-1482.119305.
  10. Bazarbashi MS, Smith MR, Karanes C et al, Succesful management of Ph choromosome choronic myelogenous leukemia with leukapheresis during pregnancy. Amer J Hematol. 1991;38:235-7.

Kaynak Göster

MLA
Tokmak, Aytekin, vd. “Chronic Myeloid Leukemia In a Pregnant Woman: A Case Report”. Cukurova Medical Journal, c. 40, sy 4, Ekim 2015, ss. 811-3, doi:10.17826/cutf.85458.