Migren tedavisinde antidepresan ilaçların rolü

Fatih Berktaş; Emine Ekemen; Olcay Kıroğlu; Fazilet Aksu

doi:10.17826/cumj.570837

EN TR

Role of antidepressant drugs in migraine treatment

Abstract

Migraine is a type of headache with a throbbing character that begins at childhood, adolescence or early adulthood, often accompanied by symptoms such as nausea, light and sound sensitivity. Depression is the most common psychiatric disorder among migraine patients. Migraine and depression affect many people and have a similar prevalence of about 10 and 15%. If migraine treatment is incomplete, depression may occur as a result of the helplessness. Treatment in migraine is carried out in two stages; acute attack and prophylactic treatment. While analgesics, non-steroidal antiinflammatory drugs, ergot alkaloids and triptans are used in acute attack, drugs such as beta blockers, antiepileptics, antidepressants are used in prophylactic treatment. The success of these drugs in reducing the number and severity of attacks in patients can not be achieved with full success. Therefore, the effects of different antidepressant drug groups are investigated. Selective serotonin reuptake inhibitors (SSRIs), selective serotonin-noradrenaline reuptake inhibitors(SNRIs) and especially tricyclic antidepressants (TCA) are preferred especially with depression, stress, anxiety and sleep disturbance in the prophylactic pharmacological treatment of patients with frequent migraine attacks. In this study we aimed to investigate the effects of antidepressants used in migraine treatment on the severity and duration of migraine.

Keywords

Migraine,Antidepressants,Depression,Treatment

Migren tedavisinde antidepresan ilaçların rolü

Öz

Migren, çocukluk, ergenlik veya erken erişkin dönemde başlayan, sıklıkla bulantı, ışık ve ses duyarlılığı gibi semptomların eşlik ettiği, periyodik aralıklarla gelen zonklayıcı karakterde bir baş ağrısı türüdür. Migrenli hastalarda en çok görülen psikiyatrik bozukluklarda ilk sırada depresyon yer almaktadır. Migren ve depresyon birçok kişiyi etkiler ve yaklaşık %10-15 dolayında benzer prevalansa sahiptir. Migren tedavisi eğer eksik yapılırsa durumun kontrol edilemez olmasının getirdiği çaresizliğin sonucunda hastalarda depresyon ortaya çıkabilmektedir. Migrenin akut ataklarının profilaksi ve tedavisi iki aşamada gerçekleştirilmektedir. Akut atakta; analjezikler ve non-steroid antiinflamatuar ilaçlar, ergot alkoloidleri ve triptanlar kullanılırken, profilaktik tedavide; beta blokörler, antiepileptikler, antidepresanlar, kalsiyum kanal blokörleri gibi ilaçlar kullanılmaktadır. Bu ilaçlarla hastalarda atakların sayısının ve şiddetinin azaltılmasında tam bir başarı elde edilememektedir. Bu sebeple son zamanlarda antidepresan ilaç gruplarının tedavideki yeri araştırılmaktadır. Özellikle depresyon, stres, anksiyete ve uyku bozukluğu ile birlikte sık migren atağı geçirenlerin, profilaktik farmakolojik tedavisinde başta trisiklik antidepresanlar (TSA) olmak üzere, selektif serotonin geri alım inhibitörleri (SSRI) ve selektif serotonin-noradrenalin geri alım inhibitörleri (SNRI) tercih edilmektedir. Bu çalışmamızda migren tedavisinde kullanılan antidepresanların migrenin şiddeti ve süresindeki etkilerini incelemek amaçlanmıştır.

Anahtar Kelimeler

: Migren,Antidepresanlar,Depresyon,Tedavi

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Derleme

Yazarlar

Fatih Berktaş ^*
0000-0001-5215-2880
Türkiye

Emine Ekemen
0000-0002-6600-9177
Türkiye

Olcay Kıroğlu
0000-0003-3182-2122
Türkiye

Fazilet Aksu
0000-0003-3585-2599
Türkiye

Yayımlanma Tarihi

29 Aralık 2019

Gönderilme Tarihi

27 Mayıs 2019

Kabul Tarihi

9 Ağustos 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 44

DOI

https://doi.org/10.17826/cumj.570837

IZ

https://izlik.org/JA56JU87YX

MLA

Berktaş, Fatih, vd. “Migren tedavisinde antidepresan ilaçların rolü”. Cukurova Medical Journal, c. 44, Aralık 2019, ss. 555-66, doi:10.17826/cumj.570837.

Cited By

Depresyonu Besin Öğeleri ile Önleyebilir veya Şiddetini Azaltabilir Miyiz?

Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

https://doi.org/10.51754/cusbed.1259315

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Role of antidepressant drugs in migraine treatment

Abstract

Keywords

Migren tedavisinde antidepresan ilaçların rolü

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Depresyonu Besin Öğeleri ile Önleyebilir veya Şiddetini Azaltabilir Miyiz?