Preemptı̇f oral tramadol-pregabalı̇n ı̇le tramadol-parasetamol kombinasyonunun postoperatı̇f tramadol tüketı̇mı̇ üzerı̇ne etkı̇lerı̇nin karşılaştırılması

Murat Türkeün Ilgınel; Demet Laflı Tunay; Yasemin Güneş; Feride Karacaer; Ebru Biricik; Özge Ilgınel

doi:10.17826/cumj.585656

EN TR

Comparison of effects of preemptive oral pregabalin-tramadol combination and paracetamol-tramadol combination administration on postoperative tramadol consumption

Abstract

Purpose: We aimed to evaluate the efficacy of preemptive oral tramadol-placebo, tramadol-pregabalin and tramadol-paracetamol combination on postoperatif tramadol consumption in patients undergoing breast reduction operation.

Materials and Methods: Sixty adult patients between 18-65 years of age, undergoing breast reduction surgery were included in this study, randomly divided into three groups. Each of groups were received 35 mg drop tramadol one hour before surgery. Additionally Group I (n=20) patients received 75 mg pregabalin tablet and Group II (n=20) patients received 500 mg paracetamol tablet preoperatively, and Group III (n=20) patients accepted as control group. 30 minutes before the end of operation Postoperative 24 hour pain scores, total tramadol consumption, supplement analgesic requirement, extubation, recovery time and side effects were recorded.

Results: Postoperative 10th and 60th min Visual Analogue Scale scores were lower in group II compared to others. The consumption of tramadol in Group I was lower than the others when the total amount of tramadol consumtion was grouped as 120 mg≥ and 120mg <.

Conclusion: The combinations of pregabalin and tramadol and paracetamol and tramadol did not cause any difference in terms of postoperative pain scores, 24-hour total tramadol consumption compared with tramadol alone.

Keywords

Patient controlled analgesia,paracetamol,preemptif analgesia

Preemptı̇f oral tramadol-pregabalı̇n ı̇le tramadol-parasetamol kombinasyonunun postoperatı̇f tramadol tüketı̇mı̇ üzerı̇ne etkı̇lerı̇nin karşılaştırılması

Öz

Amaç: Çalışmamızda preemptif oral tramadol-plasebo, tramadol-pregabalin ve tramadol–parasetamol kombinasyonlarının postoperatif tramadol tüketimi üzerine etkilerini karşılaştırmayı amaçladık.

Gereç ve Yöntem: Çalışmaya meme küçültme ameliyatı yapılacak, 18-65 yaş aralığında, 60 hasta alındı. Hastalar rastgele üç gruba ayrıldı. Operasyondan bir saat önce her üç gruba tramadol 35 mg oral damla ile grup I’e (n=20) pregabalin 75 mg tablet, grup II’ye (n=20) parasetamol 500 mg tablet, grup III’e (n=20) ise plasebo tablet verildi.Grupların postoperatif 24 saatlik ağrı skorları, total tramadol tüketimleri, ek analjezi ihtiyaçları, ekstübasyon ve derlenme zamanları ve yan etkiler kaydedildi.

Bulgular: Vizüel Analog Skala (VAS) 10. ve 60. dakika değerleri grup II’de diğer gruplardan daha düşük saptandı. Tramadol tüketiminde gruplar arasında istatiksel olarak anlamlı farklılık saptanmamış olmakla birlikte tüketilen toplam tramadol miktarı 120 mg  ve 120 mg  olarak gruplandırıldığında grup I’de tramadol tüketimi diğer iki gruptan daha düşük saptandı.

Sonuç: Meme küçültme cerrahisinde preoperatif oral yoldan uygulanan pregabalin ve tramadol kombinasyonu ile parasetamol ve tramadol kombinasyonu tek başına tramadole göre postoperatif ağrı skorları, 24 saatlik total tramadol tüketimi ve yan etkiler açısından farklılığa yol açmamıştır.

Anahtar Kelimeler

Preemptif analjezi,pregabalin,tramadol damla,parasetamol

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Murat Türkeün Ilgınel ^*
0000-0001-9183-9124
Türkiye

Demet Laflı Tunay
0000-0002-7984-1800
Türkiye

Yasemin Güneş
0000-0001-9148-3041
Türkiye

Feride Karacaer
0000-0002-1048-6505
Türkiye

Ebru Biricik
0000-0002-3355-198X
Türkiye

Özge Ilgınel Bu kişi benim
0000-0002-1079-644X
Türkiye

Yayımlanma Tarihi

29 Aralık 2019

Gönderilme Tarihi

2 Haziran 2019

Kabul Tarihi

22 Temmuz 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 44

DOI

https://doi.org/10.17826/cumj.585656

IZ

https://izlik.org/JA92TK86BH

MLA

Ilgınel, Murat Türkeün, vd. “Preemptı̇f oral tramadol-pregabalı̇n ı̇le tramadol-parasetamol kombinasyonunun postoperatı̇f tramadol tüketı̇mı̇ üzerı̇ne etkı̇lerı̇nin karşılaştırılması”. Cukurova Medical Journal, c. 44, Aralık 2019, ss. 181-9, doi:10.17826/cumj.585656.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Comparison of effects of preemptive oral pregabalin-tramadol combination and paracetamol-tramadol combination administration on postoperative tramadol consumption

Abstract

Keywords

Preemptı̇f oral tramadol-pregabalı̇n ı̇le tramadol-parasetamol kombinasyonunun postoperatı̇f tramadol tüketı̇mı̇ üzerı̇ne etkı̇lerı̇nin karşılaştırılması

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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