Serum kartonektin (CTRP-3) düzeyinin gestasyonel diyabetli ve sağlıklı gebelerde karşılaştırılması ve biyokimyasal parametreler ve insulin direnci ile ilişkisi

Burkay Yakar; Gamzecan Karakaya; Erhan Önalan; Mehmet Ferit Gürsu

doi:10.17826/cumj.735270

TR EN

Serum kartonektin (CTRP-3) düzeyinin gestasyonel diyabetli ve sağlıklı gebelerde karşılaştırılması ve biyokimyasal parametreler ve insulin direnci ile ilişkisi

Öz

Amaç: Bu çalışmada gestasyonel diyabet mellitus (GDM) tanısı alan gebelerin serum kartonektin (CTRP-3) sevilerinin sağlıklı kontrol gebe grubu ile karşılaştırılması ve Kartonektin düzeyinin gebelerin biyokimyasal parametreleri ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Kesitsel tipte tasarlanan araştırma Haziran 2016 ile Ocak 2017 tarihleri arasında yürütülmüştür. Çalışmaya 24-32 haftalık 30 GDM ve 30 sağlıklı gebe dahil edildi. Tüm katılımcılardan 12 saat açlık sonrası kan şekeri, lipid paneli, insulin, c-peptid ve kartonektin düzeyleri elde edilmiştir. Bulgular: Gestasyonel diyabeti olan katılımcıların Glikoz, HbA1C, İnsulin, C-peptid, HOMA-IR, Trigliserit, VLDL, HDL düzeyleri istatistiksel olarak kontrol grubundan yüksek saptandı. Kontrol grubunun kartonektin (CTRP-3) düzeyi 7.68±4.29 (ng/mL), GDM grubunun ortalama kartonektin düzeyi 6.95±4.02 (ng/mL) saptandı ve iki grup arasında istatistiksel anlamlı bir fark saptanmadı Sonuç: GDM’lu hasta grubunda glikoz, HbA1c, insulin, HOMA-IR, C-peptid, trigliserit ve VLDL düzeylerinin yükseldiği saptanmıştır. Gestasyonel diyabetli hastalarda kartonektin ile glikoz ve insülin düzeyleri arasında negatif korelasyon saptanmıştır.

Anahtar Kelimeler

Kartonektin (CTRP-3) , gestasyonel diyabet , insülin direnci , insülin , gebelik

Comparison of serum cartonectin (CTRP-3) level in gestational diabetes patient and healthy pregnant women and its relationship with biochemical parameters and insulin resistance

Abstract

Purpose: The aim of this study was to compare the serum cartonectin (CTRP-3) levels of patients with gestational diabetes mellitus with the healthy control pregnant group and to investigate the relationship of cartonectin with the biochemical parameters of pregnant women. Material and Methods: The cross-sectional study was conducted between June 2016 and January 2017. A total of 30 patients with GDM and 30 healthy pregnant women were included in the study. Glucose, lipid, insulin, c-peptide and cartonectin levels were obtained from all participants after 12 hours of fasting. Results: Participants with gestational diabetes glucose, HbA1C, insulin, C-peptide, HOMA-IR, triglyceride, VLDL, HDL levels were statistically higher than the control group. Cartonectin level of the control group was 7.68 ± 4.29, mean cartonectin level of the GDM group was 6.95 ± 4.02 (ng / mL) and there was no statistically significant difference between the two groups. Conclusion: Glucose, HbA1c, insulin, HOMA-IR, C-peptide, triglyceride and VLDL levels were increased in patients with GDM. Negative correlation was found between cartonectin and glucose and insulin levels in patients with gestational diabetes.

Keywords

diabetes , cartonectin

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Burkay Yakar
0000-0003-2745-6561
Türkiye

Gamzecan Karakaya
0000-0002-9699-1341
Türkiye

Erhan Önalan ^*
0000-0001-5395-0390
Türkiye

Mehmet Ferit Gürsu
0000-0003-3552-7315
Türkiye

Yayımlanma Tarihi

27 Aralık 2020

Gönderilme Tarihi

10 Mayıs 2020

Kabul Tarihi

25 Ağustos 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 45 Sayı: 4

DOI

https://doi.org/10.17826/cumj.735270

IZ

https://izlik.org/JA47EC69CR

MLA

Yakar, Burkay, vd. “Serum kartonektin (CTRP-3) düzeyinin gestasyonel diyabetli ve sağlıklı gebelerde karşılaştırılması ve biyokimyasal parametreler ve insulin direnci ile ilişkisi”. Cukurova Medical Journal, c. 45, sy 4, Aralık 2020, ss. 1476-81, doi:10.17826/cumj.735270.

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Serum kartonektin (CTRP-3) düzeyinin gestasyonel diyabetli ve sağlıklı gebelerde karşılaştırılması ve biyokimyasal parametreler ve insulin direnci ile ilişkisi

Öz

Anahtar Kelimeler

Comparison of serum cartonectin (CTRP-3) level in gestational diabetes patient and healthy pregnant women and its relationship with biochemical parameters and insulin resistance

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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