Effect of Ferula elaeochytris on irisin levels in rat heart

Nadire Eser; Ahmet Türk; Abdullah Karadağ; Atila Yoldaş

doi:10.17826/cumj.840681

TR EN

Ferula elaeochytrisin sıçan kalbinde irisin düzeylerine etkisi

Öz

Amaç: Bu çalışmanın amacı, farklı yaşlardaki sıçanlarda hayati bir organ olan kalpte bulunan irisin düzeylerini belirlemek ve Ferula elaeochytris'in (FE) irisin ekspresyonu üzerine etkisi olup olmadığını ortaya çıkarmaktır.. Gereç ve Yöntem: Çalışmamız 8 hafta boyunca FE ekstraktı verilmiş genç (4 ay), orta yaş (12 ay), yaşlı (24 ay) sıçanlar ve onların kontrol grupları olmak üzere altı grup şeklinde düzenlenmiştir. Ardından kalp dokuları alınarak, kalp dokusunda irisin seviyeleri immünohistokimyasal boyama yöntemi ile ölçülmüştür. Bulgular: Elde edilen sonuçlar histoskorlama yapılarak analiz edilmiştir. Yaşlı sıçanlarda irisin seviyesinin genç ve orta yaş sıçanlara göre istatistiksel olarak anlamlı derecede düşük olduğu gözlenmiştir. Ayrıca FE ekstraktı verilmiş bütün gruplarda irisin düzeylerinde istatistiksel olarak anlamlı derecede anlamlı artış olduğu bulunmuştur. Sonuç: FE ekstraktının doku hasarına karşı koruyucu etkisinin dışında başka yolaklar aracılığıyla da irisin seviyesini artırdığı düşünülmektedir.

Anahtar Kelimeler

İrisin , Ferula elaeochytris , yaşlanma , kalp , sıçan

Effect of Ferula elaeochytris on irisin levels in rat heart

Abstract

Purpose: The aim of this study was to determine the levels of irisin in the heart, which is a vital organ, in rats of different ages and to reveal whether Ferula elaeochytris (FE) has an effect on the expression of the irisin. Materials and Methods: Our study was designed in six groups, young (4 months), middle age (12 months), old (24 months) rats which were given FE extract for 8 weeks and their control groups. After that their heart tissues were taken and irisin levels were measured by immunohistochemical staining method. Results: The obtained results were analyzed by performing histoscoring. It was observed that the level of irisin in old rats was statistically significantly lower in young and middle age rats. In addition, irisin level of in all groups administered with FE extract was found significantly increased. Conclusion: FE extract increases the level of irisin through other pathways besides its protective effect against tissue damage.

Keywords

Irisin , Ferula elaeochytris , ageing , heart , rat

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Nadire Eser ^*
0000-0003-1607-5114
Türkiye

Ahmet Türk
0000-0003-0903-3522
Türkiye

Abdullah Karadağ
0000-0003-3620-9589
Türkiye

Atila Yoldaş
0000-0002-7807-0661
Türkiye

Yayımlanma Tarihi

30 Haziran 2021

Gönderilme Tarihi

15 Aralık 2020

Kabul Tarihi

16 Ocak 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 46 Sayı: 2

DOI

https://doi.org/10.17826/cumj.840681

IZ

https://izlik.org/JA77FB44GR

MLA

Eser, Nadire, vd. “Effect of Ferula elaeochytris on irisin levels in rat heart”. Cukurova Medical Journal, c. 46, sy 2, Haziran 2021, ss. 473-80, doi:10.17826/cumj.840681.

Cited By

A histological examination of the effects of Ferula elaeochytris extract on kidney and liver tissues in myoglobinuric acute renal failure

Biotechnic & Histochemistry

https://doi.org/10.1080/10520295.2024.2323973

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Ferula elaeochytrisin sıçan kalbinde irisin düzeylerine etkisi

Öz

Anahtar Kelimeler

Effect of Ferula elaeochytris on irisin levels in rat heart

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

A histological examination of the effects of Ferula elaeochytris extract on kidney and liver tissues in myoglobinuric acute renal failure