Effects of thyroid homeostasis, insulin resistance and some parameters on weight loss
Öz
Purpose: Many studies show that obesity is associated with increased serum thyrotropin [TSH] but the relationship between obesity, free thyroid hormones (including free triiodothyronine [FT3] and free thyroxin [FT4] is still unclear. The aim of this studywas to evaluate the effects of thyroid homeostasis, insulin resistance and blood parameters on weight loss in an obesity center.
Materials and Methods: Of 3918 patients applied to an obesity center between November 1st, 2018 and March 13th, 2020, 417 were found suitable and accepted in this obesity prevention program and retrospective, descriptive, cross-sectional study.
Results: A total of 417 patients were interviewed, 383 were female in this study. The mean age of participants was 48.20±11.03 years. In the group who lost weight; TSH, FT3, BMI, WC, HC, HbA1c and HOMA-IR index values were significantly lower in the sixth month. According to these results, the blood parameters, TSH, FT3 and insülin resistance of the patients are decreased who lose weight. Hip circumference, BMI, BFP, FT3, HbA1c and FBG were important determinants of weight loss in our univariate analyses. FT3 (odds ratio [OR]: 1.854; 95% CI: [1.223-2.811]; p=0.004), BMI (OR: 0.948; 95% CI: [0.914-0.984]; p=0.005) and FBG (OR: 0.984; 95% CI: [0.973-0.996]; p=0.007) were defined as multivariate predictors affecting weight loss.
Conclusion: This study advises that lower BMI and FBG levels, and higher fT3 concentrations are related with a better potential to lose weight in obese patients.
Anahtar Kelimeler
Kaynakça
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