Araştırma Makalesi

Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality

Cilt: 46 Sayı: 2 30 Haziran 2021
Begüm Şeyda Avci *, Adem Kaya , Hilmi Erdem Sümbül , Ferhat İçme , Hasan Yeşilağaç , Nevzat Ünal , Önder Yeşiloğlu , Hayri Çınar , Tuba Turunç
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Cukurova Medical Journal Kapak Cukurova Medical Journal
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Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality

Abstract

Purpose: In the present study, the possibility of predicting mortality with the change in coagulation parameters depending on the severity of Covid-19-associated pneumonia was investigated. Materials and Methods: A total of 137 patients with Covid-19-associated pneumonia were included in the study. The patients were divided into three groups according to the severity of pneumonia as mild, moderate and severe. According to the severity of pneumonia, the parameters of complete blood count and the levels of biochemical parameters were compared between the groups. By examining blood parameters according to mortality, ROC analysis and regression analysis were performed to determine the net effect of these parameters on mortality. Results: As the severity of pneumonia increased, Prothrombin time (PT), International normalized ratio (INR) and Activated partial thromboplastin time (aPTT) values were also increased, and a statistically significant difference was found between the groups in PT and INR values. PT, INR and aPTT levels were higher in cases with mortality. Mortality can be predicted with 93.5% sensitivity and 97.5% specificity. according to the >45.1 seconds(sec) cut-off value of the coagulation parameter (aPTT+PT. Conclusion: The coagulation parameter (aPTT + PT), whose level increases secondarily to the increase in Covid-19-associated pneumonia severity, provides successful results in predicting mortality, and may be a parameter that we can recommend in clinical use.

Keywords

Covid-19 infection , coagulation , PT , INR , aPTT , mortality

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Solunum Hastalıkları

Bölüm

Araştırma Makalesi

Yazarlar

Hayri Çınar Bu kişi benim
0000-0001-8645-3083
Türkiye

Yayımlanma Tarihi

30 Haziran 2021

Gönderilme Tarihi

18 Ocak 2021

Kabul Tarihi

19 Şubat 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 46 Sayı: 2

DOI

https://doi.org/10.17826/cumj.864023

IZ

https://izlik.org/JA87DW46CM

Kaynak Göster

RIS / Bibtex
MLA
Avci, Begüm Şeyda, vd. “Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality”. Cukurova Medical Journal, c. 46, sy 2, Haziran 2021, ss. 540-7, doi:10.17826/cumj.864023.
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