Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report

Tevfik Balcı; Durmuş Ayan; Cevdet Türkyürek; Ergül Bayram

doi:10.17826/cumj.905007

EN TR

Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report

Abstract

Purpose: The most common anemias are iron deficiency anemia (IDA) and beta-thalassemia minor (BTm). A correct differantiation of them is important in terms of preventing unnecessary iron treatment and also preventing thalassemia disease. Considering the financial limitations specifically in countries with high prevalence of thalassemia, mathematical indices, which are simpler solutions, have been used to achieve a differential diagnosis. Materials and Methods: Total of 71 cases eligible for inclusion criteria were included in the study and 11 indices were examined. 46 of the cases were in the BTm-group and 25 of the cases were in the IDA-group. The BTm-group were accepted as positive-patient-group and the IDA-group were accepted as control-group. Diagnostic criteria were evaluated with erythrocyte indices. Results: The highest Youden Index was seen in the Sirdah index (89.48%), followed by two identical performances of the Ehsani and the Mentzer indices (84.%), indicating that these three indices showed the best diagnostic performance. There were two indices with a low performance (DOR<10): The Bessmann and Ricerca indices. Conclusion: Adding appropriate indices to complete blood count (CBC) results before further examinations will be beneficial in terms of efficient use of resources.

Keywords

erythrocyte indices , differential , diagnosis , beta thalassemia minor , iron deficiency anemia

Beta talasemi minör ve demir eksikliği anemisinin ayırıcı tanısında eritrosit indekslerinin tanısal doğruluk testlerinin değerlendirilmesi: ön çalışma raporu

Öz

Amaç: En sık görülen anemiler demir eksikliği anemisi (DEA) ve beta-talasemi minördür (BTm). Bunların doğru bir şekilde ayırt edilmesi, gereksiz demir tedavisinin önlenmesi ve talasemi hastalığının önlenmesi açısından önemlidir. Özellikle talasemi prevalansının yüksek olduğu ülkelerdeki finansal kısıtlılıklar göz önüne alındığında, ayırıcı tanıya ulaşmak için daha basit çözümler olan matematiksel indeksler kullanılmıştır. Gereç ve Yöntem: Dahil edilme kriterlerine uygun toplam 71 vaka çalışmaya dahil edildi ve 11 indeks incelendi. Vakaların 46'sı BTm grubunda, 25'i ise IDA grubundaydı. BTm grubu pozitif hasta grubu, DEA grubu kontrol grubu olarak kabul edildi. Tanı kriterleri eritrosit indeksleri ile değerlendirildi. Bulgular: En yüksek Youden İndeksi Sirdah indeksinde (%89,48) görüldü, ardından Ehsani ve Mentzer indekslerinin iki özdeş performansı (%84,00) bu üç indeksin en iyi tanısal performansı gösterdiğini gösteriyor. Düşük performanslı (DOR <10) iki endeks vardı: Bessmann ve Ricerca endeksleri. Sonuç: İleri tetkiklerden önce tam kan sayımı (TKS) sonuçlarına uygun indekslerin eklenmesi kaynakların verimli kullanılması açısından faydalı olacaktır.

Anahtar Kelimeler

Eritrosit indeksleri , ayırıcı , tanı , beta talasemi minör , demir eksikliği anemisi

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Tevfik Balcı ^*
0000-0001-6212-0444
Türkiye

Durmuş Ayan
0000-0003-2615-8474
Türkiye

Cevdet Türkyürek Bu kişi benim
0000-0002-6802-8128
Türkiye

Ergül Bayram Bu kişi benim
0000-0003-1708-3036
Türkiye

Yayımlanma Tarihi

30 Eylül 2021

Gönderilme Tarihi

12 Nisan 2021

Kabul Tarihi

14 Haziran 2021

Yayımlandığı Sayı

Yıl 1970 Cilt: 46 Sayı: 3

DOI

https://doi.org/10.17826/cumj.905007

IZ

https://izlik.org/JA54PL33JA

MLA

Balcı, Tevfik, vd. “Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report”. Cukurova Medical Journal, c. 46, sy 3, Eylül 2021, ss. 1009-17, doi:10.17826/cumj.905007.

Cited By

Advances in screening of thalassaemia

Clinica Chimica Acta

https://doi.org/10.1016/j.cca.2022.08.001

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Evaluation of diagnostic accuracy tests of erythrocyte indexes in the differential diagnosis of beta thalassemia minor and iron deficiency anemia: A preliminary report

Abstract

Keywords

Beta talasemi minör ve demir eksikliği anemisinin ayırıcı tanısında eritrosit indekslerinin tanısal doğruluk testlerinin değerlendirilmesi: ön çalışma raporu

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Advances in screening of thalassaemia