Evaluation of esophageal motor functions in patients diagnosed with primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis

Volkan Gökbulut; Ömer Öztürk; Meral Akdoğan Kayhan; Mustafa Kaplan; Sabite Kacar; Hale Sümer; Püren Gökbulut; Derya Arı; Dilara Turan Gökçe

doi:10.17826/cumj.984551

EN TR

Evaluation of esophageal motor functions in patients diagnosed with primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis

Abstract

Purpose: The aim of this study was to evaluate the relationship between autoimmune liver diseases and esophageal motor disorders (EMD). Materials and Methods: 63 patients diagnosed with primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) and followed up in our hospital were included in the study. The control group consisted of 33 patients. Upper gastrointestinal endoscopy, esophageal motility study and pH meter tests were performed on all participants. Results: Of the 63 patients included in the study 49.2% of the patients, EMD was detected while 31.7% of them had pathology in the pH meter. The rates of EMD of patients with PBC, PSC and AIH were 50%, 63.6%, and 42.9%, respectively while the pathology rates of the pH meter were found as 25%, 54.5%, and 28.6%, respectively. Statistically significant difference was found between autoimmune liver disease and control group in terms of esophageal motor diseases. As a result of manometric examination, median lower esophageal sphincter resting pressure was significantly lower in autoimmune liver patients compared to the control group. Conclusion: Our study presents that EMD is common in patients with PBC, PSC, and AIH, and that the presence of cirrhosis has no impact on the development of EMD.

Keywords

primary biliary cholangitis , primary sclerosing cholangitis , autoimmune hepatitis , esophageal motility disorder

Primer biliyer kolanjit, primer sklerozan kolanjit ve otoimmün hepatit tanısı alan hastalarda özofagus motor fonksiyonlarının değerlendirilmesi

Öz

Amaç: Bu çalışmada otoimmün karaciğer hastalıkları ile özofagus motor bozuklukları (EMD) arasındaki ilişkinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Primer biliyer kolanjit (PBC), primer sklerozan kolanjit (PSC) ve otoimmün hepatit (AIH) tanısı konan ve hastanemizde takip edilen 63 hasta dahil edildi. Kontrol grubu 33 hastadan oluşturuldu. Çalışmaya dahil edilen tüm katılımcılara üst gastrointestinal endoskopi, özofagus motilite çalışması ve pH metre testleri yapıldı. Bulgular: Çalışmaya dahil edilen 63 hastanın %49.2'sinde EMD, %31,7'sinde pH metrede patoloji saptandı. PBC, PSC ve AIH'li hastaların EMD oranları sırasıyla %50, %63.6 ve %42,9 iken pH metrenin patoloji oranları sırasıyla %25, %54.5 ve %28.6 olarak bulundu. Otoimmün karaciğer hastalığı ile kontrol grubu arasında özofagus motor hastalıkları açısından istatistiksel olarak anlamlı fark bulundu Manometrik inceleme sonucunda otoimmün karaciğer hastalarında kontrol grubuna göre alt özofagus sfinkter dinlenme basıncı anlamlı olarak daha düşüktü Sonuç: Çalışmamız, PBC, PSC ve AIH'li hastalarda EMD'nin yaygın olduğunu ve siroz varlığının EMD gelişimi üzerinde hiçbir etkisi olmadığını ortaya koymaktadır.

Anahtar Kelimeler

Primer biliyer kolanjit , primer sklerozan kolanjit , otoimmün hepatit , özofagus motilite bozukluğu

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Volkan Gökbulut ^*
0000-0002-7906-2479
Türkiye

Ömer Öztürk
0000-0002-4545-7149
Türkiye

Meral Akdoğan Kayhan
0000-0003-4624-2542
Türkiye

Mustafa Kaplan
0000-0002-6959-675X
Türkiye

Sabite Kacar
0000-0002-3257-3546
Türkiye

Hale Sümer Bu kişi benim
0000-0001-5663-0683
Türkiye

Püren Gökbulut
0000-0002-6287-7655
Türkiye

Derya Arı
0000-0001-8024-781X
Türkiye

Dilara Turan Gökçe
0000-0003-3660-7237
Türkiye

Yayımlanma Tarihi

31 Mart 2022

Gönderilme Tarihi

25 Ağustos 2021

Kabul Tarihi

14 Kasım 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 47 Sayı: 1

DOI

https://doi.org/10.17826/cumj.984551

IZ

https://izlik.org/JA42LB98XZ

MLA

Gökbulut, Volkan, vd. “Evaluation of esophageal motor functions in patients diagnosed with primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis”. Cukurova Medical Journal, c. 47, sy 1, Mart 2022, ss. 21-28, doi:10.17826/cumj.984551.

Cited By

Demographic and clinical characteristics of patients with nonspecific esophageal motility disorder

Journal of Health Sciences and Medicine

https://doi.org/10.32322/jhsm.1278716

Bu eser Creative Commons Atıf-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Evaluation of esophageal motor functions in patients diagnosed with primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis

Abstract

Keywords

Primer biliyer kolanjit, primer sklerozan kolanjit ve otoimmün hepatit tanısı alan hastalarda özofagus motor fonksiyonlarının değerlendirilmesi

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Demographic and clinical characteristics of patients with nonspecific esophageal motility disorder