QTc interval is associated with increased inflammatory markers (neutrophil-to-lymphocyte ratio and LDH level) in COVID-19 patients
Öz
Purpose: This study aimed to investigate the association between QTc interval and laboratory parameters in COVID-19 patients before and after the treatment.
Materials and Methods: Forty-three COVID-19 patients who had baseline and follow-up ECG findings and laboratory reports were evaluated and 40 patients were included in the study.
Results: Among 40 patients, 16 were women and 24 were men. The neutrophil-to-lymphocyte ratio (NLR) and corrected QT (QTc) interval were significantly higher in females than males. After the treatment, a significant fall in CRP and ferritin values, and significantly prolonged QTc interval were seen. A significant positive correlation was observed between QTc interval and age, LDH levels, neutrophil and leukocyte count, NLR, magnesium levels, and heart rate of the patients prior to treatment. A positive correlation was observed between increased QTc interval and decreased LDH levels and NLR after treatment.
Conclusion: QTc prolongation was associated with increased inflammatory markers, increased NLR and LDH levels before and after treatment in COVID-19 patients. The increase in the QTc interval was correlated with the reduction in LDH levels and NLR with treatment.
Anahtar Kelimeler
COVID-19, electrocardiogram, QTc interval, inflammation, neutrophil-to-lymphocyte ratio, LDH
Destekleyen Kurum
Baskent University
Proje Numarası
E-94603339-604.01.02-4137
Teşekkür
None.
Kaynakça
- 1. Zheng HY, Zhang M, Yang CX, Zhang N, Wang XC, Yang XP, et al. Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients. Cell Mol Immunol. 2020;17(5):541-3.
- 2. Jimeno S, Ventura PS, Castellano JM, García-Adasme SI, Miranda M, Touza P, et al. Prognostic implications of neutrophil-lymphocyte ratio in COVID-19. Eur J Clin Invest. 2021;51(1):e13404.
- 3. Jain U. Effect of COVID-19 on the Organs. Cureus. 2020;12(8):e9540.
- 4. Çap M, Bilge Ö, Işık F, Burak C, Karagöz A, İnci Ü, et al. The effect of favipiravir on QTc interval in patients hospitalized with coronavirus disease 2019. J Electrocardiol. 2020;63:115-9.
- 5. Santoro F, Monitillo F, Raimondo P, Lopizzo A, Brindicci G, Gilio M, et al. QTc interval prolongation and life-threatening arrhythmias during hospitalization in patients with COVID-19. Results from a multi-center prospective registry. Clin Infect Dis. 2020.
- 6. Sonsoz MR, Oncul A, Cevik E, Orta H, Yilmaz M, Ayduk Govdeli E, et al. Wide QRS Complex and Lateral ST-T Segment Abnormality Are Associated With Worse Clinical Outcomes in COVID-19 Patients. Am J Med Sci. 2021;361(5):591-7.
- 7. Pavri BB, Kloo J, Farzad D, Riley JM. Behavior of the PR interval with increasing heart rate in patients with COVID-19. Heart Rhythm. 2020;17(9):1434-8.
- 8. Ece İ, Koçoğlu M, Kavurt AV, Bağrul D, Gül AEK, Koca S, et al. Assessment of Cardiac Arrhythmic Risk in Children With Covid-19 Infection. Pediatr Cardiol. 2021;42(2):264-8.
- 9. Rubin GA, Desai AD, Chai Z, Wang A, Chen Q, Wang AS, et al. Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic. JAMA Netw Open. 2021;4(4):e216842.
- 10. Das MK, El Masry H. Fragmented QRS and other depolarization abnormalities as a predictor of mortality and sudden cardiac death. Curr Opin Cardiol. 2010;25(1):59-64.
