Factors associated with delayed vascular maturation in infants with retinopathy of prematurity not requiring treatment

Yıl 2016, Cilt: 41 Sayı: 2, 347 - 353, 30.06.2016

Ebru Esen Selçuk Sızmaz Hacer Yapıcıoğlu Ferda Özlü Kemal Yar İlker Ünal Nihal Demircan

Öz

Purpose: The aim of this study is to determine risk factors associated with delayed regression of retinopathy of prematurity and prolonged vascular completion in patients not requiring treatment.
Material and Methods: Patients with acute retinopathy of prematurity not requiring treatment were grouped as control and delayed vascularization groups, on condition that retinal vascularization had completed before postconceptional age of 50 weeks or not. Patients with retinopathy of prematurity requiring treatment constituted treatment group. A total of 17 possible risk factors that may affect the time course of retinal vascularization in patients with acute retinopathy of prematurity were evaluated. 
Results: Multivariate regression analysis showed that low Apgar score at fifth minute and blood transfusion were associated with an increased risk of delayed vascularization when compared with controls. Low gestational age and presence of patent ductus arteriosus were risk factors for retinopathy of prematurity that require treatment when compared with delayed vascularization group. 
Conclusion: Low Apgar score and blood transfusion might be predictive factors for prolonged retinal vascularization in patients with retinopathy of prematurity not requiring treatment. Having a higher gestational age and absence of patent ductus arteriosus, appeared as reducing the risk of progressing to serious disease requiring treatment for an infant with retinopathy of prematurity that undergo regression slowly.

Anahtar Kelimeler

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Tedavi gerektirmeyen prematüre retinopatili yenidoğanlarda gecikmiş retina damar matürasyonuyla ilişkili faktörler

Öz

Amaç: Bu çalışmanın amacı tedavi gerektirmeyen prematüre retinopatisi olan hastalarda, retinopatinin gerilemesinde gecikme ve retina damar matürasyonunda uzama ile ilişkili olabilecek risk faktörlerini belirlemektir.Gereç ve Yöntem: Tedavi gerektirmeyen prematüre retinopatili hastalar, retina damarlanmasının 50. postkonsepsiyonel haftadan önce tamamlanmış olup olmamasına göre kontrol ve gecikmiş matürasyon grubu olarak ikiye ayrıldı. Tedavi gerektiren prematüre retinopatili hastalar ise tedavi grubunu oluşturdu. Prematüre retinopatisi hastalarında retinanın damarlanma sürecini etkileyebilecek 17 olası risk faktörü gruplar arsında karşılaştırıldı.Bulgular: Çoklu regresyon analizinde, 5. dakikadaki düşük Apgar skoru ve kan transfüzyonu öyküsü kontrol grubu kıyaslandığında gecikmiş matürasyon ile ilişkili bulundu. Gecikmiş matürasyonlu hastalar tedavi gerektiren prematüre retinopatili bebeklerle kıyaslandığında ise, düşük doğum haftası ve patent duktus arteriosus varlığı, tedavi gerektiren prematüre retinopatisi gelişmesi ile ilişkili bulundu.Sonuç: Tedavi gerektirmeyen prematüre retinopatisi hastalarında 5. dakikadaki Apgar skorunun düşük olması ve kan transfüzyonu öyküsü, retina damarlanmasının uzun sürede tamamlanacağının habercisi olabilir. Doğum haftasının yüksek olması ve patent duktus arteriosus bulunmaması ise prematüre retinopatisi yavaş gerileyen infantlarda tedavi gerekecek evrelere ilerleme riskinin düşük olacağı konusunda fikir verebilir.

Anahtar Kelimeler

prematüre retinopatisi, uzamış gerileme, gecikmiş retina damar matürasyonu

Kaynakça

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