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Major depresyonda elektrokonvulsif terapinin oksidatif metabolizma üzerine etkisi

Yıl 2017, Cilt 42, Sayı 3, 513 - 517, 30.09.2017
https://doi.org/10.17826/cutf.323838

Öz

Amaç: Elektrokonvulsif terapinin (EKT) majör depresyonda etkinliği bilinmektedir. Bu çalışmada majör depresyonda EKT’nin total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi üzerindeki etkilerine bakılmıştır.

Gereç ve Yöntem: DSM-IV’e göre majör depresyon tanısı konulan 23 hasta ve 22 sağlıklı kontrol çalışmaya alındı. Hastalara sosyodemografik ve klinik bilgilendirme formu uygulandı. Hasta ve kontrollerden venöz kan örnekleri alındı. serum total antioksidan, total oksidan düzeylerine bakıldı. 

Bulgular: Elektrokonvulzif terapi uygulaması öncesi hasta grubunda antioksidan seviye kontrol grubuna kıyasla daha düşük bulunmuştur. Hasta grubunda EKT uygulaması sonrası antioksidan seviye elektrokonvulzif terapi öncesine göre anlamlı düzeyde artmıştır. Elektrokonvulzif terapi uygulaması sonrası antioksidan seviye kontrol grubu ile kıyaslandığında anlamlı farklılık kalmamıştır. EKT öncesi ve sonrasında bakılan total oksidan seviye ve oksidatif stres indeksi açısından hasta ve kontrol grupları arasında anlamlı farklılık saptanmamıştır.

Sonuç: EKT uygulaması sonrasında hastalarda total antioksidan seviye düzeyinin artması, EKT’nin majör depresyon hastalarında antioksidan seviye artışına neden olduğunu düşündürmektedir. 


Kaynakça

  • 1. Gold PW, Machado-Vieira R, Pavlatou MG. Clinical and biochemical manifestations of depression: relation to the neurobiology of stress. Neural Plast. 2015;2015:581976 .
  • 2. Marneros A. Mood disorders: epidemiology and natural history. Psychiatry. 2006,5:119-22.
  • 3. Chiriţa AL, Gheorman V, Bondari D, Rogoveanu I. Current understanding of the neurobiology of major depressive disorder. Rom J Morphol Embryol. 2015;56 (2 Suppl):651-8.
  • 4. Michel TM, Camara S, Tatschner T, Frangau S, Sheldrick AJ, Riederer P at al. Increased xanthine oxidase in the talamu and putamen in depression. World J Biol Psychiatry. 2008;12:1-7.
  • 5. Palta P, Samuel LJ, Miller ER, Szanton SL. Depression and oxidative stress: results from a meta-analysis of observational studies. Psychosom Med. 2014;76:12-9.
  • 6. Sujita Kumar Kar, Siddharth Sarkar. Neuro-stimulation Techniques for the Management of Anxiety Disorders: An Update. Clin Psychopharmacol Neurosci. 2016;14:330–7.
  • 7. UK ECT Review Group. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;8;361:799-808.
  • 8. Heijnen WT, Birkenhager TK, Wierdsma AI, van den Broek WW. Antidepressant pharmacotherapy failure and response to subsequent electroconvulsive therapy: a meta-analysis. J Clin Psychopharmacol. 2010;30:616-9.
  • 9. Holtzmann J, Polosan M, Baro P, Bougerol T. ECT: from neuronal plasticity to mechanisms underlying antidepressant medication effect. Encephale. 2007;33:572-8.
  • 10. Valko M, Rhodes C J, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-inducedcancer. Chem Biol Interact. 2006;160:1–40.
  • 11. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease Int J Biochem Cell Biol. 2007;39:44-84.
  • 12. Andreazza AC, Kauer-Santanna M, Frey BN, Bond DJ, Kapczinski F, Young LT el al. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord. 2008;111:135-44.
  • 13. Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev. 2009;2:63-7.
  • 14. Genc A, Kalelioglu T, Karamustafalioglu N, Tasdemir A, Gungor FC, Genc ES et al. Level of plasma thioredoxin in male patients with manic episode at initial and post-electroconvulsive or antipsychotic treatment. Psychiatry Clin Neurosci. 2015;69:344-50.
  • 15. Zupan G, Pilipovic K, Hrelja A, Peternel S. Oxidative stress parameters in different rat brain structures after electroconvulsive shock-induced seizures. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:771-7.
  • 16. Barichello T, Bonatto F, Agostinho FR, Reinke A, Moreira JC, Dal-Pizzol F et al. Structure-related oxidative damage in rat brain after acute and chronic electroshock. Neurochem Res. 2004;29:1749-53.
  • 17. Kartalci S, Karabulut AB, Ozcan AC, Porgali E, Unal S. Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2011;15;35:1689-94.
  • 18. Jorgensen A, Krogh J, Miskowiak K, Bolwig TG, Kessing LV, Fink-Jensen A et al. Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. J Affect Disord. 2013;149:355-62.
  • 19. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38:1103-11.
  • 20. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37:277–85.
  • 21. Jimenez-Fernandez S, Gurpegui M, Diaz-Atienza F, Perez-Costillas L, Gerstenberg M, Correll CU. Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: results from a meta-analysis. J Clin Psychiatry. 2015;76:1658-67.
  • 22. Cumurcu BE, Ozyurt H, Etikan I, Demir S, Karlidag R. Total antioxidant capacity and total oxidant status in patient with major depression: Impact of antidepressant treatment. Psychiatry Clin Neurosci. 2009;63:639-45.
  • 23. Yanik M, Erel O, Kati M. The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatr. 2004;16:200-3.
  • 24. Bulut M, Altındağ A, Deveci Z, Kaya MC, Bülbül F, Taşkın A et al. Elektrokonvulzif tedavi ve farmakoterapi ile tedavi edilen iki uçlu bozukluk hastalarında oksidatif parametreler. Journal of Mood Disorders. 2013;3:93-9.

Effect of electroconvulsive therapy on oxidative metabolism in major depressive disorder

Yıl 2017, Cilt 42, Sayı 3, 513 - 517, 30.09.2017
https://doi.org/10.17826/cutf.323838

Öz

Purpose: Electroconvulsive therapy (ECT) has been shown to be effective for majör depressive disorder. This study aimed to evaluate the association between ECT and the effects of ECT on total antioxidant level, total oxidant level, oxidative stress index in major depression.

Material and Methods: The study group consisted of 23 inpatients with majör depressive disorder defined by DSM-IV criteria and 22 healty volunteers. Socio-demographic and clinical information were collected using structured questionnaire. Venous blood samples were taken from patients and controls. The biochemical parameters analyzed were serum total antioxidant level, total oxidant level.

Results: Total antioxidant level was lower in the majör depressive disorder group compared with those of the controls before ECT. Total antioxidant levels were significantly increased with electrocunvulsive therapy in patient group. There was no significant difference for total antioxidant levels after ECT. There was no significant difference between patient and control groups in terms of total oxidant level and oxidative stress index before and after ECT.

Conclusion: The results suggest that ECT leads to an increase in antioxidant levels in patients with majör depressive disorder.


Kaynakça

  • 1. Gold PW, Machado-Vieira R, Pavlatou MG. Clinical and biochemical manifestations of depression: relation to the neurobiology of stress. Neural Plast. 2015;2015:581976 .
  • 2. Marneros A. Mood disorders: epidemiology and natural history. Psychiatry. 2006,5:119-22.
  • 3. Chiriţa AL, Gheorman V, Bondari D, Rogoveanu I. Current understanding of the neurobiology of major depressive disorder. Rom J Morphol Embryol. 2015;56 (2 Suppl):651-8.
  • 4. Michel TM, Camara S, Tatschner T, Frangau S, Sheldrick AJ, Riederer P at al. Increased xanthine oxidase in the talamu and putamen in depression. World J Biol Psychiatry. 2008;12:1-7.
  • 5. Palta P, Samuel LJ, Miller ER, Szanton SL. Depression and oxidative stress: results from a meta-analysis of observational studies. Psychosom Med. 2014;76:12-9.
  • 6. Sujita Kumar Kar, Siddharth Sarkar. Neuro-stimulation Techniques for the Management of Anxiety Disorders: An Update. Clin Psychopharmacol Neurosci. 2016;14:330–7.
  • 7. UK ECT Review Group. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;8;361:799-808.
  • 8. Heijnen WT, Birkenhager TK, Wierdsma AI, van den Broek WW. Antidepressant pharmacotherapy failure and response to subsequent electroconvulsive therapy: a meta-analysis. J Clin Psychopharmacol. 2010;30:616-9.
  • 9. Holtzmann J, Polosan M, Baro P, Bougerol T. ECT: from neuronal plasticity to mechanisms underlying antidepressant medication effect. Encephale. 2007;33:572-8.
  • 10. Valko M, Rhodes C J, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-inducedcancer. Chem Biol Interact. 2006;160:1–40.
  • 11. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease Int J Biochem Cell Biol. 2007;39:44-84.
  • 12. Andreazza AC, Kauer-Santanna M, Frey BN, Bond DJ, Kapczinski F, Young LT el al. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord. 2008;111:135-44.
  • 13. Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev. 2009;2:63-7.
  • 14. Genc A, Kalelioglu T, Karamustafalioglu N, Tasdemir A, Gungor FC, Genc ES et al. Level of plasma thioredoxin in male patients with manic episode at initial and post-electroconvulsive or antipsychotic treatment. Psychiatry Clin Neurosci. 2015;69:344-50.
  • 15. Zupan G, Pilipovic K, Hrelja A, Peternel S. Oxidative stress parameters in different rat brain structures after electroconvulsive shock-induced seizures. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:771-7.
  • 16. Barichello T, Bonatto F, Agostinho FR, Reinke A, Moreira JC, Dal-Pizzol F et al. Structure-related oxidative damage in rat brain after acute and chronic electroshock. Neurochem Res. 2004;29:1749-53.
  • 17. Kartalci S, Karabulut AB, Ozcan AC, Porgali E, Unal S. Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2011;15;35:1689-94.
  • 18. Jorgensen A, Krogh J, Miskowiak K, Bolwig TG, Kessing LV, Fink-Jensen A et al. Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. J Affect Disord. 2013;149:355-62.
  • 19. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38:1103-11.
  • 20. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37:277–85.
  • 21. Jimenez-Fernandez S, Gurpegui M, Diaz-Atienza F, Perez-Costillas L, Gerstenberg M, Correll CU. Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: results from a meta-analysis. J Clin Psychiatry. 2015;76:1658-67.
  • 22. Cumurcu BE, Ozyurt H, Etikan I, Demir S, Karlidag R. Total antioxidant capacity and total oxidant status in patient with major depression: Impact of antidepressant treatment. Psychiatry Clin Neurosci. 2009;63:639-45.
  • 23. Yanik M, Erel O, Kati M. The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatr. 2004;16:200-3.
  • 24. Bulut M, Altındağ A, Deveci Z, Kaya MC, Bülbül F, Taşkın A et al. Elektrokonvulzif tedavi ve farmakoterapi ile tedavi edilen iki uçlu bozukluk hastalarında oksidatif parametreler. Journal of Mood Disorders. 2013;3:93-9.

Ayrıntılar

Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Araştırma
Yazarlar

Şengül ŞAHİN
0000-0002-5371-3907


Özlem AYBASTI Bu kişi benim


Gülçin ELBOĞA Bu kişi benim


Abdurrahman ALTINDAĞ Bu kişi benim


Lut TAMAM
0000-0002-9750-7531
Türkiye

Yayımlanma Tarihi 30 Eylül 2017
Yayınlandığı Sayı Yıl 2017, Cilt 42, Sayı 3

Kaynak Göster

MLA Şahin, Ş. , Aybastı, Ö. , Elboğa, G. , Altındağ, A. , Tamam, L. "Major depresyonda elektrokonvulsif terapinin oksidatif metabolizma üzerine etkisi" . Cukurova Medical Journal 42 (2017 ): 513-517 <https://dergipark.org.tr/tr/pub/cumj/issue/26525/323838>