Primer ovaryan leimyosarkom

Yıl 2018, Cilt: 43 Sayı: 4, 1038 - 1041, 29.12.2018

Gökmen Sukgen Adem Altunkol

https://doi.org/10.17826/cumj.409817

Cited By: 2

Öz

Over leimyosarkomu çok kötü prognozlu agresif nadir
bir tümördür. Uterin tümörlerin  aksine
ovaryan düz kas tümörleri, yumurtalık tümörlerinin sadece% 1'ini içeren çok
nadir tümörlerdir. Ovaryan leimyosarkom genellikle postmenapozal periyotta
görülür. Ancak bu vakada olduğu gibi premenapozal periyottada tanı konabilir.
Primer pür ovaryan leimyosarkomlar ovaryan düz kas hücreli tümörlerin malign
alt grubunu oluşturur. Bu nedenle kökenleri, etiyolojisi, histolojik
özellikleri, klinik davranışları ve optimal tedavileri hala belirsizdir. 59
yaşında bir hasta, karnında kitle ve ağrı şikayeti ile hastanemize başvurdu.
Ameliyat öncesi çeklen abdominal ultrasonografi ve bilgisayarlı tomografide tüm
abdomeni dolduran kitle tespit edildi.Total histerektomi, bilateral
salpingo-ooferektomi, omentektomi, appendektomi, bilateral pelvik ve paraaortik
lenf nodu diseksiyonu ve peritoneal yıkama yapıldı. Histopatolojik incelemede
primer ovaryan leimyosarkom tespit edildi. Bildiğimiz kadarıyla mevcut
vakamızla birlikte literatürde 73 vaka bildirilmiştir.

Anahtar Kelimeler

Ovaryan neoplasm, sarkom, leimyosarkom

Primary leimyosarcoma of the ovary

Öz

Ovarian leimyosarcoma is a rare aggressive tumor with a very bad prognosis. Contrary to their uterine counterparts, ovarian smooth muscle tumors are extremely rare comprising only 1% of ovarian tumors. Ovarian leimyosarcoma is generally seen in the postmenopausal period. Here we report a 59-year old patient diagnosed as  as ovarian primary leimyosarcoma. 

Anahtar Kelimeler

Ovarian neoplasm, sarcoma, leimyosarcoma

Kaynakça

• 1. Vijaya Kumar J, Khurana A, Kaur P, Chuahan AK, Singh S. A rare presentation of primary leiomyosarcoma of ovary in a young woman. Ecancermedicalscience 2015; 21; 9:524.
• 2. Bouie SM, Cracchiolo B, Heller D. Epithelioid leiomyosarcoma of the ovary. Gynecol Oncol 2005; 97: 697-9.
• 3. Lerwill MF, Sung R, Oliva E, Prat J, Young RH. Smooth muscle tumors of the ovary. A clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis. Am J Surg Pathol 2004; 28: 1436-51.
• 4. He M, Deng YJ, Zhao DY, Zhang Y, Wu T. Synchronous leiomyosarcoma and fibroma in a single ovary: A case report and review of the literature. Oncol Lett 2016; 11: 2510-4.
• 5. Azoury AS, Woodruff JD. Primary ovarian sarcomas: report of 43 cases from the Emil Novak Tumor Registry. Obstet Gynecol 1971; 37: 920–91.
• 6. Rasmussen CC, Skilling JS, Sorosky JI, Lager DJ, Buller RE. Stage IIIC ovarian leiomyosarcoma in a premenopausal woman with multiple recurrences: prolonged survival with surgical therapy. Gynecol Oncol 1997; 66: 519-25.
• 7. Piura B, Rabinovich A, Yanai-Inbar I, Glezerman M. Primary sarcoma of the ovary: report of five cases and review of the literature. Eur J Gynaecol Oncol 1998; 19: 257-61.
• 8. O’Sullivan SG, Das Narla L, Ferraro E. Primary ovarian leiomyosarcoma in an adolescent following radiation for medulloblastoma. Pediatr Radiol 1998; 28: 468-70.
• 9. Monk B, Nieberg R, Berek J. Primary leiomyosarcoma of the ovary in a perimenarchal female. Gynecol Oncol 1993; 48: 389-93.
• 10. Young RH, Scully RE. Sarcomas metastatic to the ovary: a report of 21 cases. Int J Gynecol Pathol 1990; 9: 231-52.
• 11. Friedman HD, Mazur M. Primary ovarian leiomyosarcoma. An immunohistochemical and ultrastructural study. Arch Pathol Lab Med 1991; 115: 941-5.
• 12. Reddy S, Pui Poon T, Ramaswamy G, Tcherktkoff V. Leiomyosarcoma of the ovary. N Y State J Med 1985; 85: 218-20.
• 13. Muntz HG, Jones MA, Goff BA, Fuller Jr AF, Nikrui N, Rice LW. Malignant mixed mullerian tumors of the ovary: experience with surgical cytoreduction and combination chemotherapy. Cancer 1995; 76: 1209-13.
• 14. Barakat RR, Rubin SC, Wong G, Saigo PE, Markman M, Hoskins WJ. Mixed mesodermal tumor of the ovary: analysis of prognosis factors in 31 cases. Obstet Gynecol 1990; 80: 660-4.
• 15. Nieminen U, von Numers C, Purola E. Primary sarcoma of the ovary. Acta Obstet Gynecol Scand 1969; 48: 423-32.
• 16. Nasu M, Inuoe J, Matsui M, Minoura S, Matsubara O. Ovarian leiomyosarcoma:an autopsy case report. Pathol Int 2000; 50: 162-5.
• 17. Nicotina PA, Antico F, Caruso C, Triolo O. Primary ovarian leiomyosarcoma. Proliferation rate and survival. Eur J Gynaecol Oncol 2004; 25: 515-6.
• 18. Dai Y, Shen K, Lang JH, Huang HF, Pan LY, Wu M, et al. Primary sarcoma of the ovary: Clinicopathological characteristics, prognostic factors and evaluation of therapy. Chin Med J 2011; 124: 1316-21.