Serum Copper, Zinc And Magnesium Levels in Children with Various Malignant Disorders

Year 2013, Volume: 38 Issue: 4, 587 - 591, 01.12.2013

Atila Tanyeli Levent Kayrın Yurdanur Kılınç Gülay Sezgin Ayşe Ekizer Özkan , Defne Ay Tuncel İbrahim Bayram Serhan Küpeli

Abstract

Introduction: The minute amounts of several trace elements including copper, zinc and magnesium play some roles as essential constituents of various biological organs. The serum concentrations these elements are modified in some malignancies. The aim of this study is to investigate the copper, zinc and magnesium levels in the serum of children with various malignant disorders. Material and Methods: The serum levels of copper, zinc and magnesium were measured in 82 children with various malignant disorders and in 21 age-matched healty controls using an atomic absorbtion spectrophotometer. Results: The serum Cu, Zn and Mg concentrations were significantly higher than matched control values among patients with acute lymphoblastic leukemia (ALL) (p

Keywords

Copper, Zinc, Magnesium, Leukemia, Solid tumor, Copper/Zinc ratio

Çocuklarda Çeşitli Malign Hastalıklarda Serumdaki Bakır, Çinko ve Magnezyum Seviyeleri

Abstract

Giriş: Bakır, çinko, magnezyum dahil olmak üzere birçok iz elementlerin küçük miktarları dahi birçok biyolojik organların temel bileşenleri olarak rol oynamaktadır. Bu elementlerin serum konsantrasyonları bazı malign durumlarda değişiklik gösterirler. Bu çalışmanın amacı, çeşitli malign hastalığı olan çocukların serumlarındaki bakır, çinko ve magnezyum düzeylerini araştırmaktır. Materyal ve Metot: Çeşitli malign hastalıklara sahip 82 çocuğun ve kontrol grubunu oluşturan yaş olarak denk 21 sağlıklı çocuğun bakır, çinko ve magnezyum düzeyleri atomik absorpsiyon spektrofotometre kullanılarak ölçüldü. Bulgular: Akut lenfoblastik lösemili hastalarda ki (ALL) serum Cu, Zn ve Mg konsantrasyonları (p

Keywords

Bakır, Çinko, Magnezyum, Lösemi, Solid tümör, Bakır/Çinko oranı

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• Yazışma Adresi / Address for Correspondence: Dr. Serhan Küpeli Çukurova University, Faculty of Medicine Department of Pediatric Hematology and Oncology Balcalı 01330 , Adana /TURKEY e-mail: [e-mail] Tel: [phone] Fax: [phone] geliş tarihi/received :28.02.2013 kabul tarihi/accepted:01.04.2013