Secondary Lymphoma in a Patient with a History of Unilateral Retinoblastoma

Yıl 2015, Cilt: 40 Sayı: Ek 1, 33 - 37, 09.10.2015

Banu Kozanoğlu Gülay Sezgin Emine Bagır Ayse Özkan , İbrahim Bayram Atila Tanyeli Serhan Küpeli

https://doi.org/10.17826/cutf.94994

Öz

Second malignancies develop with increased incidence in patients with herediter retinoblastoma. The most common second malignancies in retinoblastoma survivors are soft tissue sarcoma and osteosarcoma. Lymphoma developing as a second malignancy has rarely been reported. Here we report a case of lymphoma diagnosed in a 13 year-old-boy, 12 years after the diagnosis of unilateral retinoblastoma having heterozygous p.R552 (c.1654C> T) mutation, treated with enucleation and radiotherapy. The risk of second tumour is higher in the hereditary retinoblastoma, especially in cases undergoing external beam radiation therapy

Anahtar Kelimeler

lymphoma, retinoblastoma, second neoplasm, children

Retinoblastom Öyküsü Olan Bir Hastada İkincil Lenfoma

Öz

İkincil malign hastalıklar herediter retinoblastomlu hastalarda artmış bir sıklıkta gelişebilmektedir. Retinoblastom yaşayanlarında en sık rastlanan malign hastalıklar yumuşak doku sarkomları ve osteosarkomdur. İkincil tümör olarak lenfoma gelişmesi ise nadiren bildirilmiştir. Bu yazıda ünilateral retinoblastom nedeniyle enükleayon ve radyoterapi ile tedavi edilen, 12 yıl sonra lenfoma tanısı alan ve heterozigot p.R552 (c.1654C> T) mutasyonu saptanan 13 yaşında bir hasta rapor edilmiştir. İkincil tümör gelişme riski özellikle radyoterapi verilmiş herediter retinoblastomlu hastalarda daha fazladır

Anahtar Kelimeler

lenfoma, retinoblastom, ikincil tümör, çocuklar

Kaynakça

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