The value of VEGF and IGF-1 in the diagnosis retinopathy of prematurity and follow-up of response to laser therapy

Yıl 2019, Cilt: 44 Sayı: 3, 745 - 752, 30.09.2019

Cüneyt Tayman Ufuk Çakır Özdemir Özdemir

https://doi.org/10.17826/cumj.472840

Öz

Purpose: Early recognition of the retinopathy of prematurity (ROP), timely and appropriate treatment will contribute to the developmental process of the infant and increase the quality of life by preventing vision loss. We here by aimed to figure out the value of the blood levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in infants with severe ROP requiring laser therapy.

Materials and Methods: Very low birth weight infants (VLBW, ≤1500 g and gestational age ≤32 weeks) were included in the study. Blood samples for the evaluation of markers were obtained from the cord at birth for all preterms and at the same postpartum corrected age (34 weeks) for ROP and control group.

Results: The mean serum VEGF level was 185.6 ± 88.1 pg/mL in the control group and 590.2 ± 97.4 pg/mL before laser treatment in the ROP group . It was decreased to 83.7 ± 25.4 pg/mL at 4 day after laser treatment in the ROP group). No significant difference was existed between the values of IGF-1 before and after laser treatment in infants with severe ROP.

Conclusion: Serum VEGF and IGF-1 levels may be suggested as a sensitive marker of severe ROP. Additionally, the decrease in serum levels of VEGF after laser therapy can be used as an indicator for the efficacy of laser treatment.

Anahtar Kelimeler

insulin-like growth factor-1, retinopathy of prematurity, vascular endothelial growth factor

Prematür retinopatisinin tanısı ve lazer tedavisine cevabın takibinde VEGF ve IGF-1’in değeri

Öz

Amaç: Prematüre retinopatisinin (ROP) erken tanınması, zamanında ve uygun tedavisi, bebeğin gelişim sürecine katkıda bulunacak ve görme kaybını önleyerek yaşam kalitesini artıracaktır. Biz burada lazer tedavisi gerektiren şiddetli ROP olan bebeklerde vasküler endotelyal büyüme faktörü (VEGF) ve insülin benzeri büyüme faktörü-1'in (IGF-1) kan düzeylerinin değerini belirlemeyi amaçladık.

Gereç ve Yöntem: Çok düşük doğum ağırlıklı bebekler (ÇDDA, ≤1500 g ve gestasyonel yaş ≤32 hafta) çalışmaya alındı. ROP ve kontrol grubu için tüm pretermler için doğumdan itibaren ve aynı doğum sonrası düzeltilmiş yaşta (34 hafta) belirteçlerin değerlendirilmesi için kan örnekleri alındı.

Bulgular: Kontrol grubunda ortalama serum VEGF düzeyi 185,6 ± 88,1 pg / mL ve ROP grubunda lazer tedavisi öncesi 590,2 ± 97,4 pg / mL idi. ROP grubunda lazer tedavisinden 4 gün sonra 83,7 ± 25,4 pg / mL'ye düştü Şiddetli ROP'lu bebeklerde lazer tedavisi öncesi ve sonrasında IGF-1 değerleri arasında anlamlı fark yoktu. 

Sonuç: Serum VEGF ve IGF-1 seviyeleri, şiddetli ROP'un duyarlı bir belirteçleri olarak önerilebilir. Ek olarak, lazer tedavisinden sonra VEGF'nin serum seviyelerindeki azalma, lazer tedavisinin etkinliği için bir gösterge olarak kullanılabilir.

Anahtar Kelimeler

insülin benzeri büyüme faktörü-1, prematürite retinopatisi, vasküler endotelyal büyüme faktörü

Kaynakça

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