Relation of complete blood count parameters and derivatives with radiologic staging of knee osteoarthritis

Yıl 2019, Cilt: 44 Sayı: 4, 1364 - 1370, 29.12.2019

Tuba Tülay Koca , Murat Baykara , Burhan Fatih Koçyiğit

https://doi.org/10.17826/cumj.507406

Cited By: 3

Öz

Purpose: In this study, the relationship between radiologic progression and complete blood count parameters and derivatives, which have appeared as biomarkers for systemic inflammation in recent years, were evaluated in patients with knee osteoarthritis (OA). 

Materials and Methods: This retrospective study included 209 consecutive patients 40 to 80 years of age diagnosed with knee OA according to 2010 American College of Rheumatology clinical criteria. Participants’ demographic characteristics, complete blood parameters and derivatives were recorded. Blood platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to neutrophil ratio (MNR) levels were calculated. 

Results: The majority of patients with high-grade knee OA were determined to be females of an advanced agewith higher patellar tendon length (PTL). Their leukocyte (WBC), neutrophil, and NLR levels were significantly higher than others. When we compared this group of patients to four groups (grades 1-4), advanced age, female gender, PTL, Q angle, WBC, neutrophils, mean platelet volume (MPV), and NLR were significantly higher in patients with grade 4 knee OA. 

Conclusion: In advanced knee OA, patellofemoral Q angle and PTL increased along with serum WBC, neutrophil, NLR, and MPV levels while RBC, Hb, lymphocyte, monocyte, basophil, and eosinophil levels were reduced. In the future, these parameters may be used as a guide to OA progression.

Anahtar Kelimeler

Osteoarthritis, inflammation, inflammatuar markers, complete blood count, neutrophil to lymphocyte ratio

Diz osteoartriti radyolojik evrelemesi ile tam kan sayım parametreleri ve türevleri ilişkisi

Öz

Amaç: Bu çalışmada diz osteoartritli (OA) hastalarda, son yıllarda sistemik inflamasyon için biyobelirteç olarak ortaya çıkan, tam kan sayımı parametre ve türevleri ile radyolojik ilerleme arasındaki ilişki değerlendirildi.  

Gereç ve Yöntem: Bu retrospektif çalışma 2010 Amerikan Romatoloji Koleji klinik kriterlerine göre diz OA tanısı konmuş 40 ila 80 yaşları arasındaki 209 ardışık hastayı içermektedir. Katılımcıların demografik özellikleri, tam kan parametreleri ve türevleri kaydedildi. Kan trombosit / lenfosit oranı (PLR), nötrofil / lenfosit oranı (NLR) ve monosit / nötrofil oranı (MNR) seviyeleri hesaplandı.

Bulgular: Yüksek dereceli diz OA'sı olan hastaların çoğunluğunun, ileri yaşta, artmış patellar tendon uzunluğu (PTL) olan kadın olduğu belirlendi. Lökosit (WBC), nötrofil ve NLR  düzeyleri diğer hastalardan anlamlı derecede yüksekti. Bu hasta grubunu dört gruba (örn. evre 1-4 arası) ayırdığımızda, 4. evre diz OA'lı hastalarda ileri yaş, kadın cinsiyet, PTL, Q açısı; WBC, nötrofiller  ortalama trombosit hacmi (MPV) ve NLR anlamlı olarak yüksek bulundu.

Sonuç: İleri diz OA olgularında patellofemoral Q açısı ve PTL, serum WBC, nötrofil, NLR ve MPV ile birlikte artmış; RBC, Hb, lenfosit, monosit, bazofil ve eozinofil düzeyleri azalmıştır. Gelecekte, bu parametreler hastalığın ilerlemesinde bir rehber olarak kullanılabilir.

Anahtar Kelimeler

Osteoartrit, inflamasyon, inflamatuar belirteçler, tam kan sayımı, nötrofil lenfosit oranı

Kaynakça

• Zhai G, Randell EW, Rahman P. Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility. Rheumatology (Oxford). 2018 Jan 24. doi: 10.1093/rheumatology/kex497. [Epub ahead of print]
• Taşoğlu Ö, Bölük H, Şahin Onat Ş, Taşoğlu İ, Özgirgin N. Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity? Clin Rheumatol. 2016 Jun;35(6):1579-83. doi: 10.1007/s10067-016-3170-8. Epub 2016 Jan 16.
• Raveendranath Raveendranath, Shankar Nachiket, Narayanan Sujatha,Ranganath Priya, and Devi Rema. Bilateral Variability of the Quadriceps Angle (Q angle) in an Adult Indian Population. Iran J Basic Med Sci. 2011 Sep-Oct; 14(5): 465–471.
• Lu W, Yang J, Chen S, Zhu Y, Zhu C. Abnormal Patella Height Based on Insall-Salvati Ratio and its Correlation with Patellar Cartilage Lesions: An Extremity-Dedicated Low-Field Magnetic Resonance Imaging Analysis of 1703 Chinese Cases. Scand J Surg. 2016 Sep;105(3):197-203. doi: 10.1177/1457496915607409. Epub 2015 Sep 28.
• Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port. 2015 Jan-Feb;28(1):99-106. Epub 2015 Feb 27.
• Pavelka K. [Osteoarthritis as part of metabolic syndrome?] Vnitr Lek. 2017 Fall;63(10):707-711. [Article in Czech]
• Urban H, Little CB. The role of fat and inflammation in the pathogenesis and management of osteoarthritis. Rheumatology (Oxford). 2018 Feb 9. doi: 10.1093/rheumatology/kex399. [Epub ahead of print]
• Patra D, Sandell LJ. Evolving biomarkers in osteoarthritis. J Knee Surg. 2011 Dec;24(4):241-9.
• Rousseau JCh, Garnero P. Biological markers in osteoarthritis. Bone. 2012 Aug;51(2):265-77. doi: 10.1016/j.bone.2012.04.001. Epub 2012 Apr 12.
• Wang X, Oo WM, Linklater JM. What is the role of imaging in the clinical diagnosis of osteoarthritis and disease management? Rheumatology (Oxford). 2018 Jan 16. doi: 10.1093/rheumatology/kex501. [Epub ahead of print]
• Hafezi-Nejad N, Demehri S, Guermazi A, Carrino JA. Osteoarthritis year in review 2017: updates on imaging advancements. Osteoarthritis Cartilage. 2018 Jan 9. pii: S1063-4584(18)30022-0. doi: 10.1016/j.joca.2018.01.007. [Epub ahead of print]
• de Visser HM, Sanchez C, Mastbergen SC, Lafeber FPJG, Henrotin YE, Weinans H. Fib3-3 as a Biomarker for Osteoarthritis in a Rat Model with Metabolic Dysregulation. Cartilage. 2018 Jan 1:1947603518754629. doi: 10.1177/1947603518754629. [Epub ahead of print]
• Schiphof D, van den Driest JJ, Runhaar J. Osteoarthritis year in review 2017: rehabilitation and outcomes. Osteoarthritis Cartilage. 2018 Jan 9. pii: S1063-4584(18)30018-9. doi: 10.1016/j.joca.2018.01.006. [Epub ahead of print]
• Zhang C, Li T, Chiu KY, Wen C, Xu A, Yan CH. FABP4 as a biomarker for knee osteoarthritis. Biomark Med. 2018 Feb;12(2):107-118. doi: 10.2217/bmm-2017-0207.
• Watt FE. Osteoarthritis biomarkers: year in review. Osteoarthritis Cartilage. 2017 Oct 26. pii: S1063-4584(17)31277-3. doi: 10.1016/j.joca.2017.10.016. [Epub ahead of print]
• Appleton CT. Osteoarthritis year in review 2017: biology. Osteoarthritis Cartilage. 2017 Oct 20. pii: S1063-4584(17)31256-6. doi: 10.1016/j.joca.2017.10.008.
• Fioravanti A, Tenti S, Pulsatelli L, Addimanda O. Could myeloperoxidase represent a useful biomarker for erosive osteoarthritis of the hand? Scand J Rheumatol. 2018 Jan 29:1-3. doi: 10.1080/03009742.2017.1386796. [Epub ahead of print]
• Ramonda R, Lorenzin M, Modesti V, Campana C, Ortolan A, Frallonardo P, et al. Serological markers of erosive hand osteoarthritis. Eur J Intern Med. 2013 Jan;24(1):11-5. doi: 10.1016/j.ejim.2012.10.002. Epub 2012 Oct 25.
• Zhang J. Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis. BMC Musculoskelet Disord. 2018 Jan 19;19(1):22. doi: 10.1186/s12891-018-1932-y.
• Taşoğlu Ö, Şahin A, Karataş G, Koyuncu E, Taşoğlu İ, Tecimel O, et al. Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity. Medicine (Baltimore). 2017 Feb;96(6):e6073. doi: 10.1097/MD.0000000000006073.
• Shi J, Zhao W, Ying H, Du J, Chen J, Chen S, et al. The relationship of platelet to lymphocyte ratio and neutrophil to monocyte ratio to radiographic grades of knee osteoarthritis. Z Rheumatol. 2017 Jul 5. doi: 10.1007/s00393-017-0348-7. [Epub ahead of print]
• Hanada M, Takahashi M, Furuhashi H, Koyama H, Matsuyama Y. Elevated erythrocyte sedimentation rate and high-sensitivity C-reactive protein in osteoarthritisof the knee: relationship with clinical findings and radiographic severity. Ann Clin Biochem. 2016 Sep;53(Pt 5):548-53. doi: 10.1177/0004563215610142. Epub 2015 Sep 17.
• Rodrıguez-carrıo J, Alperı-lopez M, Lopez P, Alonso-castro S, Ballına-garcıa FJ, Suarez A. Redcelldistributionwidth is associatedwithcardiovascular risk anddiseaseparameters in rheumatoidarthritis. Rheumatology (Oxford). 2014. pii: keu245.
• Mercan R, Bitik B, Tufan A, Bozbulut UB, Atas N, Ozturk MA, et al. The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis.J Clin Lab Anal. 2015 Dec 14. doi: 10.1002/jcla.21908. [Epub ahead of print]
• Fu H, Qin B, Hu Z, Ma N, Yang M, Wei T, et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61(3-4):269-73.
• Uslu AU, Küçük A, Şahin A, Ugan Y, Yılmaz R, Güngör T, et al. Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio.Int J Rheum Dis. 2015 Sep;18(7):731-5
• Tekeoğlu İ, Gürol G, Harman H, Karakeçe E, Çiftçi İH. Overlooked hematological markers of disease activity in rheumatoid arthritis.Int J Rheum Dis. 2015 Dec 1. doi: 10.1111/1756-185X.12805. [Epub ahead of print]
• Cui LH. Research progress on the etiology and treatment of patellofemoral pain syndrome. Zhongguo Gu Shang. 2017 Jul 25;30(7):680-684. doi: 10.3969/j.issn.1003-0034.2017.07.021. [Article in Chinese]
• Mehl J, Feucht MJ, Bode G, Dovi-Akue D, Südkamp NP, Niemeyer P. Association between patellar cartilage defects and patellofemoral geometry: a matched-pair MRI comparison of patients with and without isolated patellar cartilage defects. Knee Surg Sports Traumatol Arthrosc. 2016 Mar;24(3):838-46. doi: 10.1007/s00167-014-3385-7. Epub 2014 Oct 30.