Importance of cytokeratin-20 expression in papillary urothelial neoplasia

Year 2020, Volume: 45 Issue: 4, 1326 - 1332, 27.12.2020

Onur Ceylan , İbrahim Karabulut

https://doi.org/10.17826/cumj.714836

Abstract

Purpose: The aim of this study is to determine the role of Cytokeratin 20 (CK20) expression in the diagnosis of papillary urothelial neoplasms of the bladder, and its relationship with histological grade, recurrence and other prognostic factors.
Materials and Methods: Patients diagnosed with papillary urothelial neoplasm of bladder transurethral resection (TUR) specimens between January 2011 and December 2016 were retrospectively analyzed. Of the 136 selected patients, 32 (24%) were diagnosed with urothelial papilloma, 8 (6%) with papillary urothelial neoplasm of low malignant potential (PUNLMP), 36 (26%) with low grade non-invasive papillary urothelial carcinoma (LGNIPUC), 12 (9%) with high grade non-invasive papillary urothelial carcinoma (HGNIPUC) and 48 (35%) were diagnosed with high grade invasive papillary urothelial carcinoma (HGIPUC). There was no patient diagnosed with LGIPUC. The correlation between CK20 expression and histological grade, tumor recurrence, presence of progression and presence/absence of invasion was investigated.
Results: There was a significant difference between PUNLMP and LGNIPUK in terms of CK20 expression in favor of LGNIPUK. Also there was a significant correlation between histological grade, presence of invasion, recurrence, progression and CK20 expression in patients diagnosed with Papillary Urothelial Neoplasm.
Conclusion: This study supports that CK20 is an important marker in the differentiation between PUNLMP and LGNIPUC, as well as in the determination of histological grade in urothelial carcinomas.

Keywords

Papillary Urothelial Neoplasm, CK20 Expression, Prognostic Markers

Supporting Institution

None to declare

Thanks

No acknowledgement to declare.

Papiller ürotelyal neoplazilerde sitokeratin-20 ekspresyonunun önemi

Abstract

Amaç: Bu çalışmanın amacı, mesanenin papiller ürotelyal neoplazilerinde önemli bir immünhistokimyasal belirteç olan Sitokeratin 20 (CK20) ekspresyonunun tanıdaki rolünü, histolojik grade, nüks ve diğer prognostik faktörler ile ilişkisini belirlemektir.
Gereç ve Yöntem: Ocak 2011 ile Aralık 2016 tarihleri arasındaki mesane transüretral rezeksiyon (TUR) spesmenlerine ait papiller ürotelyal neoplazi tanısı almış olgular retrospektif olarak incelendi. Seçilen 136 hastadan 32'si (% 24) ürotelyal papillom, 8'i (%6) malignite potansiyeli belirsiz papiller ürotelyal neoplazi (PUNLMP), 36'sı (%26) low grade non invaziv papiller ürotelyal karsinom (LGNİPÜK), 12'si (%9) high grade non invaziv papiller ürotelyal karsinom (HGNIPÜK) ve 48'i (% 35) high grade invaziv papiller ürotelyal karsinom (HGIPÜK) tanısı almıştı. Low grade invaziv papiller ürotelyal karsinom tanısı alan hasta yoktu. CK20 ekspresyonu ile histolojik grade, tümör nüksü, progresyon varlığı ve invazyon varlığı/yokluğu arasındaki ilişki araştırıldı.
Bulgular: PUNLMP ve LGNİPÜK arasında LGNIPÜK lehine CK20 ekspresyonu açısından önemli fark vardı. Ayrıca Papiller Ürotelyal Neoplazi tanısı alan vakalarda histolojik grade, invazyon varlığı, nüks ve progresyon ile CK20 ekspresyonu arasında anlamlı ilişki bulundu.
Sonuç: Bu çalışma CK20’ nin gerek PUNLMP ve LGNİPUK ayrımında gerekse Ürotelyal Karsinomlarda histolojik grade belirlenmesinde önemli bir belirteç olduğunu desteklemektedir.

Keywords

Papiller Ürotelyal Neoplazm, CK20 Ekspresyonu, Prognostik Belirteçler

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