Müziğin strese bağlı indüklenen hormonlar ve oksidatif stres üzerine etkisi

Year 2020, Volume: 45 Issue: 4, 1493 - 1498, 27.12.2020

Sule Terzioglu-usak , Aleyna Dal , Hilal Yanık , Birsen Elibol

https://doi.org/10.17826/cumj.735738

Cited By: 1

Abstract

Amaç: Perinatal stresin, kaygı ve depresyonun organizmaların gelişim dönemini etkilediği düşünülmektedir. Bu çalışmada perinatal dönemde farklı müzik türlerine maruz kalmış sıçanların depresyon benzeri davranışları, adrenokortikotropik hormon (ACTH), kortikosteron (CORT) ve paratiroid hormon (PTH) serum düzeyleri ile serum oksidatif stres üzerindeki etkilerini araştırmayı amaçladık.
Gereç ve Yöntem: Gebe Wistar albino sıçanlar rastgele dört kafese ayrıldı; kontrol grubu (müzik yok), klasik müzik grubu (D Major'da Canon / Johann Pachelbel, 60 dB), geleneksel Sufi müzik grubu (Whirling Derwish / Omar Faruk Tekbilek, 30 dB) ve metal müzik grubu (In Your Face/ Children of Bodom, 120 dB). Her müzik grubundaki anneler ve yavrular, hamileliğin 10. gününden doğumdan sonra 21. güne kadar 1 saat / gün kendi müzik türlerine maruz bırakıldılar.
Bulgular: Kuyruktan asma testi sonuçlarına göre klasik müzik grubunda depresyon düzeyini gösteren hareketsizliğin kontrol grubuna göre arttığı gözlenmiştir. Hormonal düzeyde, sadece serum ACTH seviyelerinde önemli değişiklikler elde edilmiştir. Bu değer kontrol grubuna göre klasik müzik grubunda artarken, tasavvuf müzik grubunda azalmıştır. Ayrıca metal müzik grubunda kontrol grubuna göre oksidatif stres endeksinde belirgin bir artış saptanmıştır.
Sonuç: Hamilelik sırasında dinlenen müziğin ses yoğunluğu, yavruların ileri yaşamlarındaki stres ve depresyon düzeyinde hayati önem taşımaktadır.

Keywords

Hipotalamik-hipofiz-adrenal (HPA) ekseni, Perinatal müzik, Depresyon benzeri davranış, Paratiroid hormon, Oksidatif stres

Supporting Institution

Bezmialem Vakıf Üniversitesi

Project Number

BAP-3.2015/22 ve BAP-12.2016/31

Effects of music on stress induced hormones and oxidative stress levels

Abstract

Purpose: Perinatal stress, anxiety, and depression have been thought having influences on the developmental period of organisms. In this study, we aimed to investigate the effects of different types of music exposure during perinatal period on depression-like behavior, serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and parathyroid hormone (PTH) as well as serum oxidative stress index in rats.
Materials and Methods: Pregnant Wistar albino rats were randomly divided into four cages; the control group (no music exposure), the classical music group (Canon in D Major/ Johann Pachelbel, 60 dB), the traditional Sufi music group (Whirling Derwish/ Omar Faruk Tekbilek, 30 dB), and the rock music group (In Your Face/ Children of Bodom, 120 dB). Dams and pups in each music groups listened to their own music 1 hour/day from gestational day 10 to postnatal day 21.
Results: According to the results of tail suspension test, the longer duration of immobility which shows the level of depression was increased in the classical music group compared to the control group. At hormonal level, significant alterations were obtained only in serum ACTH levels. It was increased in the classical music group, while decreased in the sufi music group compared to the control group. In addition, a marked increase in oxidative stress index was found in the rock music group compared to the control group.
Conclusion: The sound intensity of music which is listened during the pregnancy has vital importance in the stress and depression level of offspring.

Keywords

Hypothalamic-pituitary-adrenal (HPA) axis, perinatal music, depression-like behavior, parathyroid hormone (PTH), oxidative stress

Project Number

BAP-3.2015/22 ve BAP-12.2016/31

References

• Munck A, Naray-Fejes-Toth A. Glucocorticoid action. In: DeGroot LJ, editor. Endocrinology. 3rd ed. 1642-56. Philadelphia: W B Saunders, 1995.
• Stephens MA, Wand G. Stress and the HPA axis: Role of glucocorticoids in alcohol dependence. Alcohol Res.2012;34:468-83.
• Rhodes ME. Chapter 10-adrenocorticotropic hormone A2-ink, George. In Stress: Neuroendocrinology and Neurobiology. Academic Press. 109-116. San Diego, CA, USA, 2017.
• Goncharova ND. Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation. Front Endocrinol (Lausanne) 2013;4:26.
• Chrousos GP, Pavlaki AN, Magiakou MA. Glucocorticoid Therapy and Adrenal Suppression. Endotext. 2011.
• Cobb HP. The effects of stress on the blood calcium level in the male white rat (Rattus norvegicus). Virginia: University of Richmond. 1985.
• Terzioglu-Usak S, Elibol B, Dalli T, Guler C, Aysan E. Effect of restraint stress on plasma PTH concentration and its molecular targets expressions in wistar rats. Int J Endocrinol Metab. 2018;16:e66979.
• Wigram T, Pedersen IN, Bonde LO. A comprehensive guide to music therapy: Theory, clinical practice, research and training. London: Jessica Kingsley. 2002.
• Xing Y, Xia Y, Kendrick K, Liu X, Wang M, Wu D, et al.. Mozart, mozart rhythm and retrograde mozart effects: evidences from behaviours and neurobiology bases. Sci Rep.2016;6:18744.
• Kirste I, Nicola Z, Kronenberg G, Walker TL, Liu RC, Kempermann G. Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis. Brain Struct Funct. 2015;220:1221-8.
• Escribano B, Quero I, Feijoo M, Tasset I, Montilla P, Tunez I. Role of noise and music as anxiety modulators: relationship with ovarian hormones in the rat. Appl Anim Behav Sci.2014;152:73-82.
• Sutoo D, Akiyama K. Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation. Brain Res. 2004;1016:255-62.
• Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, et al. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells. J Cardiothorac Surg.2012;7:26.
• Gao J, Chen S, Lin S, Han H. Effect of music therapy on pain behaviors in rats with bone cancer pain. J BUON.2016;21:466-72.
• Kim HY, Ko KJ, Nam SY, Jeong HJ, Kim HM. The sound of a buk (Korean Traditional Drum) attenuates anaphylactic reactions by the activation of estrogen receptor-beta. Int Arch Allergy Immunol.2015;167:242-9.
• Zhang SY, Peng GY, Gu LG, Li ZM, Yin SJ. Effect and mechanisms of gong-tone music on the immunological function in rats with liver (Gan)-Qi depression and spleen (Pi)-Qi deficiency syndrome in rats. Chin J Integr Med.2013;19:212-6.
• Elibol-Can B, Dursun I, Telkes I, Kilic E, Canan S, Jakubowska-Dogru E. Examination of age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats. Dev Neurobiol. 2014;74:498-513.
• Aycicek A, Erel O. Total oxidant/antioxidant in jaundiced newborns before and after phototherapy. J Pediatr (RioJ). 2007;83(4):319-22.
• Naqvi F, Haider S, Perveen T, Haleem DJ. Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats. Pharmacol Rep. 2012;64:64-9.
• Sampaio WCM, Ribeiro MC, Costa LF, Souza WC, Castilho GM, Assis MS, et al. Effect of music therapy on the developing central nervous system of rats. Psychol Neurosci.2017;10:176-88.
• Attoui N, Bouhali IE, Tayaa H, Habbachi W, Bairi A, Tahraoui A. Music therapy modulates combined predator and noise stress induced anxiety-like behavior in male Wistar rat. Middle East J Sci Res. 2015;23(3):374-7.
• Michaud DS, McLean J, Keith SE, Ferrarotto C, Hayley S, Khan SA, et al. Differential impact of audiogenic stressors on Lewis and Fischer rats: behavioral, neurochemical, and endocrine variations. Neuropsychopharmacol.2003;28:1068-81.
• De Boer SF, Van der Gugten J, Slangen JL. Plasma catecholamine and corticosterone responses to predictable and unpredictable noise stress in rats. Physiol Behav. 1989;45:789-95.
• Krebs H, Macht M, Weyers P, Weijers HG, Janke W. Effects of stressful noise on eating and non-eating behavior in rats. Appetite. 1996;26:193-202.
• Gerra G, Zaimovic A, Franchini D, Palladino M, Giucastro G, Reali N, et al. Neuroendocrine responses of healthy volunteers to 'techno-music': relationships with personality traits and emotional state. Int J Psychophysiol. 1998;28:99-111.
• Bagheri Hosseinabadi M, Khanjani N, Ebrahimi MH, Mirbadie SR, Biganeh J. The effects of industrial noise exposure on lipid peroxidation and antioxidant enzymes among workers. Int Arch Occup Environ Health. 2019;92(7):1041-6.
• Karafakioglu YS. Effects of α lipoic acid on noise induced oxidative stress in rats. Saudi J Biol Sci. 2018;26(5):989-94.