Multiple skleroz ile periodontal sağlık arasındaki ilişki: klinik- immunolojik çalışma

Year 2021, Volume: 46 Issue: 2, 436 - 442, 30.06.2021

Bahar Alkaya , Mustafa Özcan , Mehmet Cenk Haytaç , Meltem Demirkıran , Mehmet Balal

https://doi.org/10.17826/cumj.838546

Abstract

Amaç: Multiple Sklerozlu hastalarda nörolojik bulguların şiddeti ile periodontal durum arasındaki potansiyel ilişkinin klinik ve enflamatuar belirteçler kullanılarak değerlendirilmesidir.
Gereç ve Yöntem: Multiple Skleroz (MS) tanısı konulmuş, 18-69 yaş arası 131 hasta çalışmaya dahil edildi. Çalışma grupları hastalara verilen Genişletilmiş Engellilik Durumu Ölçek skorlarına (EDSS) göre oluşturuldu. Birinci grup EDSS ≤3, ikinci grup ≥3,5 şeklinde planlandı. Ağız içi muayenede cep derinliği (CD), diş eti çekilmesi (DEÇ), gingival indeks (GI), plak indeksi (PI) değerleri kaydedildi. Hastalardan diş eti oluğu sıvısı (DOS) örneği alındı. Elde edilen veriler sonucunda EDSS skorları farklı olan gruplar arasındaki klinik ve immünolojik ölçümlerin karşılaştırılması hedeflendi.
Bulgular: Çalışmanın sonucunda EDSS skoru yüksek olan grupta GI, PI, CD, DEÇ ölçümleri EDSS skoru düşük olan gruba göre daha yüksek bulunurken, immünolojik ölçümler arasında fark gözlenmemiştir. Korelasyon, regresyon analizlerinde ise periodontal sağlığın EDSS ve pro-inflamatuar sitokin IL-6 ile ile ilişkili olduğu gözlenmiştir.
Sonuç: Çalışmanın sonucuna göre MS hastalarında hastalığın şiddeti arttıkça periodontal klinik durumların da olumsuz yönde etkilendiği görülmüştür. Bu konunun daha iyi anlaşılabilmesi için daha geniş kitlelerde yapılacak immünolojik, genetik, nörolojik çalışmalara ihtiyaç vardır.

Keywords

multiple skleroz, periodontal sağlık, edss

The relationship between multiple sclerosis and periodontal health: a clinical-immunological study

Abstract

Purpose: The aim of this study is to evaluate the potential relationship between the severity of neurological signs and the periodontal condition in patients with multiple sclerosis by using clinical and inflammatory markers.
Materials and Methods: 131 patients aged 18-69 who were diagnosed with Multiple sclerosis (MS) were included in the study. The participants were categorized into two groups based on their Expanded Disability Status Scale (EDSS) score: the first group had EDSS score ≤3; and the second group had EDSS score ≥3,5. Neurogical examination was carried out by a neurologist and MS types, EDSS scores were recorded. Detailed periodontal examination including pocket depth (PD), gingival recession (GR), gingival index (GI) and plaque index (PI) were recorded, and gingival fluid (GF) samples were collected.
Results: The results showed that the GI, PI, PD, GR were found to be higher in patients with higher EDSS scores compared to patients with lower EDSS score. No significant differences were observed between immunological measurements. The correlation and regression analyzes revealed that periodontal status is associated with EDSS scores and the pro-inflammatory cytokine IL-6 levels.
Conclusion: In conclusion; it has been observed that as the severity of the disease increases in MS patients, periodontal clinical conditions are also negatively affected. In order to better understand this subject immunological, genetic, neurological studies should be performed in larger study populations are needed.

Keywords

Multiple sclerosis, periodontal health, EDSS

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