Obsesif kompulsif bozuklukta serum doğal antioksidan düzeyleri

Year 2021, Volume: 46 Issue: 2, 481 - 487, 30.06.2021

Bahadır Demir , Aslıhan Gümüşlü , Şengül Şahin , Gulcin Elboga , Abdurrahman Altındağ

https://doi.org/10.17826/cumj.841038

Abstract

Amaç: Bu çalışmada obsesif kompulsif bozukluk (OKB) hastalarında ürik asit, albümin, total bilirubin ve gamma glutamil transferaz (GGT) gibi serumda ölçülebilen oksidatif stres ile ilişkili basit laboratuvar parametrelerini sağlıklı kontroller ile karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya Gaziantep Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri polikliniğinde DSM-5 kriterlerine göre OKB tanısı ile tedavi edilen hastalar alınmıştır. OKB tanısı konulan 117 hasta ve hasta grubu ile demografik veriler ile eşleşebilecek 80 kişi sağlıklı kontrol grubu olarak alındı. Hasta ve kontrol grubu serum ürik asit, albümin, total bilirubin ve GGT açısından karşılaştırıldı. Hastaların klinik özellikleri Yale Brown Obsesyon Kompulsiyon Ölçeği (Y-BOCS) ve Klinik Global İzlenim Şiddet Ölçeği (KGI-S) ile değerlendirildi.
Bulgular: Hasta grubu yaş ortalaması 36.68±13.06 iken kontrol grubunun 35.54±8.82’di. Total bilirubin düzeyine bakıldığında hasta grubunda 0.69±2.19 mg/dL ve kontrol grubunda 0.63±0.47 mg/dL olmakla birlikte gruplar arasında anlamlı farklılık vardı. GGT düzeyi hasta grubunda 22.85±15.80 U/L ve kontrol grubunda ise 19.29±11.52 U/L olmakla birlikte gruplar arasında anlamlı fark yoktu.
Sonuç: Hastalar bilirubin dışında doğal antioksidan açısından kontrollerden farklı değildi. Çalışmamızdaki bulgular OKB ile ürik asit, albümin ve GGT arasında nedensel bir ilişki olduğunu desteklememektedir.

Keywords

obsesif kompulsif bozukluk,, oksidatif stres, ürik asit, albümin, bilirubin

Supporting Institution

Yoktur

Serum natural antioxidant levels in obsessive-compulsive disorder

Abstract

Purpose: The aim of this stıudy was to examine easy laboratory parameters associated with oxidative stress that can be measured in serum such as uric acid, albumin, total biluribine and gamma glutamyl transferase (GGT) in patients with obsessive compulsive disorder (OCD) by comparing them with healthy controls.
Materials and Methods: 117 Patients who were diagnosed as OCD according to DSM-5 criteria and 80 healthy controls were included in the study. Patient and control groups were compared in terms of serum uric acid, albumin, total biluribine and GGT. Yale Brown Obsession Compulsion Scale and Clinical Global Impression Scale were used to assess clinical characteristics of the patients.
Results: The mean age of the patients was 36.68±13.06 years, while it was 35.54±8.82 in control group. Total biluribin levels was higher in patients (0.69±2.19 mg/dL) than controls (0.63±0.47 mg/dL). Although the GGT level was 22.85 ± 15.80 U / L in the patient group and 19.29 ± 11.52 U / L in the control group, there was no significant difference between the groups.
Conclusion: Patients did not differ from controls in terms of natural antioxidant, except bilirubin. The results do not support a causal relationship between OCD and uric acid, albumine and GGT.

Keywords

Obsessive compulsive disorder, oxidative stress, uric acid, albumin, bilirubine, gamma glutamyl transferase

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