QTc interval is associated with increased inflammatory markers (neutrophil-to-lymphocyte ratio and LDH level) in COVID-19 patients

Yıl 2021, Cilt: 46 Sayı: 4, 1711 - 1718, 30.12.2021

Şerife Torun Irem Karaman Nurtaç Özer Çaşıt Olgun Çelik M. Şule Akçay

Öz

Purpose: This study aimed to investigate the association between QTc interval and laboratory parameters in COVID-19 patients before and after the treatment.
Materials and Methods: Forty-three COVID-19 patients who had baseline and follow-up ECG findings and laboratory reports were evaluated and 40 patients were included in the study.
Results: Among 40 patients, 16 were women and 24 were men. The neutrophil-to-lymphocyte ratio (NLR) and corrected QT (QTc) interval were significantly higher in females than males. After the treatment, a significant fall in CRP and ferritin values, and significantly prolonged QTc interval were seen. A significant positive correlation was observed between QTc interval and age, LDH levels, neutrophil and leukocyte count, NLR, magnesium levels, and heart rate of the patients prior to treatment. A positive correlation was observed between increased QTc interval and decreased LDH levels and NLR after treatment.
Conclusion: QTc prolongation was associated with increased inflammatory markers, increased NLR and LDH levels before and after treatment in COVID-19 patients. The increase in the QTc interval was correlated with the reduction in LDH levels and NLR with treatment.

Anahtar Kelimeler

COVID-19, electrocardiogram, QTc interval, inflammation, neutrophil-to-lymphocyte ratio, LDH

Destekleyen Kurum

Baskent University

Proje Numarası

E-94603339-604.01.02-4137

Teşekkür

None.

QTc aralığı, COVID-19 hastalarında artan inflamatuar belirteçlerle (nötrofil-lenfosit oranı ve LDH seviyesi) ilişkilidir

Öz

Amaç: Bu çalışma, COVID-19 hastalarının tedavi öncesi ve sonrası QTc aralığı ile laboratuvar parametreleri arasındaki ilişkiyi araştırmayı amaçlamıştır.
Gereç ve Yöntem: Başlangıç ve takip EKG bulguları ve laboratuvar raporları olan 43 COVID-19 hastası değerlendirildi ve çalışmaya 40 hasta dahil edildi.
Bulgular: 40 hastanın 16'sı kadın, 24'ü erkekti. Nötrofil/lenfosit oranı (NLO) ve düzeltilmiş QT (QTc) aralığı kadınlarda erkeklere göre anlamlı olarak daha yüksekti. Tedavi sonrası CRP ve ferritin değerlerinde belirgin düşüş ve QTc intervalinde belirgin uzama görüldü. QTc aralığı ile hastaların yaşı, tedavi öncesi LDH düzeyleri, nötrofil ve lökosit sayıları, NLO, magnezyum düzeyleri ve kalp atım hızı arasında anlamlı pozitif korelasyon gözlendi. Tedavi sonrası artan QTc aralığı ile azalmış LDH seviyeleri ve NLO arasında pozitif bir korelasyon gözlendi.
Sonuç: QTc uzaması, COVID-19 hastalarında tedaviden önce ve sonra artan inflamatuar belirteçler, artan NLR ve LDH seviyeleri ile ilişkili olarak gözlemlenmiştir. QTc aralığındaki artış, tedavi ile LDH seviyelerindeki ve NLR'deki azalma ile korele idi.

Anahtar Kelimeler

COVID-19, elektrokardiyogram, QTc aralığı, inflamasyon, nötrofil-lenfosit oranı, LDH

Proje Numarası

E-94603339-604.01.02-4137

Kaynakça

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