Premenstrual sendromu olan adolesan kızlarda serebral lateralizasyon

Yıl 2023, Cilt: 48 Sayı: 1, 84 - 91, 31.03.2023

Cansu Çobanoğlu Osmanlı Berkan Şahin Koray Karabekiroğlu

https://doi.org/10.17826/cumj.1180572

Öz

Amaç: Bu çalışmada amacımız, Premenstrual Sendromu olan kızlarda serebral lateralizasyon bulgularını sağlıklı adölesanlarla farklılıkları ya da benzerlikleri karşılaştırmaktır. Ayrıca Premenstrüel Sendromun şiddeti ile bu bulgular arasında bir korelasyon olup olmadığını da değerlendirmeyi amaçladık.
Gereç ve Yöntem: Çalışmaya dahil edilme kriterlerine uygun 14-18 yaş arası 79 kız ergen çalışmayı tamamladı. Premenstrüel Değerlendirme Formu (PDF)’ nu dolduran tüm katılımcılar ile menstruasyon sikluslarının luteal dönemlerinde (adet olmadan önceki 1-7. günler arasında) ikinci görüşme yapıldı. Tüm katılımcılar Harris lateralleşme testini tamamladı.
Bulgular: Katılımcıların yaş ortalaması 192,85 ± 14,54 (aralık 167-216) ay olarak saptandı. PMS puanı ortancası 2,26 (1,00-5,10) olarak saptandı. 35 (44,30%) katılımcı PMS tanısı almazken, 20 (25,32%) katılımcıda hafif, 14 (17,72%) katılımcıda orta, 10 (12,66%) katılımcıda şiddetli PMS tespit edildi. 67 (84,81%) katılımcıda sağ el dominans ve 3 (3,80%) katılımcıda sol el dominans iken 9 (11,39%) katılımcıda elde belirsizlik olduğu görüldü. 41 (51,90%) katılımcıda el ve göz dominansı aynı tarafta iken, 11 (13,92%) katılımcıda çapraz lateralizasyon (tamamı sağ el, sol göz) saptandı. PMS grubunda el ve göz için belirsiz lateralizasyon (Harris lateralleşme puanı 1 veya 2 olmak) anlamlı derecede yüksek bulundu.
Sonuç: Çalışmamız, PMS tanısı alan grupta, kontrol grubuna göre lateralizasyonun (el-göz) daha az görülmesi lateralizasyon sorununa neden olan durumun PMS için ortak bir etyolojiden kaynaklanıp kaynaklanmadığı sorusunu akla getirmektedir. Etiyolojiye katkıda bulunabilecek faktörler ve çalışmamızda sunduğumuz birtakım kısıtlılıklar göz önüne alınarak yapılacak ileri araştırmalara ihtiyaç vardır.

Anahtar Kelimeler

Premenstrüel Sendrom, adolesan, serebral lateralizasyon

Cerebral lateralization in adolescent girls with premenstrual syndrome

Öz

Purpose: In this study, it was aimed to compare differences and similarities the cerebral lateralization of adolescent girls with Premenstrual Syndrome (PMS) with the control group. We also aimed to investigate whether there was a relationship between PMS severity and cerebral lateralization.
Materials and Methods: A total of 79 female adolescents aged 14-18 years who met the study inclusion criteria completed the study. A second interview was held with all participants who filled out the Premenstrual Assessment Form (PAF) during the luteal periods of menstrual cycles (1-7 days before menstruation). All participants completed the Harris lateralization test.
Results: The mean age was 192.85 ± 14.54 (range 167 - 216) months. The median PMS score was found to be 2.26 (1.00 - 5.10). While PMS was not detected in 35 (44.30%) participants, mild PMS was detected in 20 (25.32%) participants, moderate in 14 (17.72%), and severe in 10 (12.66%) participants. Sixty-seven (84.81%) participants had right hand dominance and three (3.80%) left hand dominance, nine (11.39%) participants had hand uncertainty. While the hand and eye dominance were on the same side in 41 (51.90%) participants, cross-lateralization (all right hand, left eye) was detected in 11 (13.92%) participants. Indeterminate lateralization (Harris lateralization score of 1 or 2) for the hand and eye was significantly higher in the PMS group.
Conclusion: The findings raise the question of whether lateralization (hand-eye) is less common in individuals with PMS and whether there will be a common etiology for lateralization problem and PMS. Further studies are needed considering the factors that may contribute to this etiology and some of the limitations we have presented in our study.

Anahtar Kelimeler

Premenstrual syndrome, adolescence, cerebral lateralization

Kaynakça

• Yonkers KA, O'Brien PS, Eriksson E. Premenstrual syndrome. Lancet. 2008;371:1200-10.
• Campagne DM, Campagne G. The premenstrual syndrome revisited. Eur J Obstet Gynecol Reprod Biol. 2007;130:4-17.
• Johnson SR. Premenstrual syndrome, premenstrual dysphoric disorder, and beyond: a clinical primer for practitioners. Obstet Gynecol. 2004;104:845-59.
• Borenstein JE, Dean BB, Endicott J, Wong J, Brown C, Dickerson V et al. Health and economic impact of the premenstrual syndrome. J Reprod Med. 2003;48:515-24.
• Tomruk N, Karamustafalıoğlu N, Kükürt R, Alpay N. Menstrual cycle phases in acute psychiatric hospitalizations. Klin Psikofarmakol Bulteni. 2000;10:121-8.
• Souza EGV, Ramos MG, Hara C, Stumpf BP, Rocha FL. Neuropsychological performance and menstrual cycle: a literature review. Trends Psychiatry Psychother. 2012;34:5-12.
• Hylan TR, Sundell K, Judge R. The impact of premenstrual symptomatology on functioning and treatment-seeking behavior: experience from the United States, United Kingdom, and France. J Womens Health Gend Based Med. 1999;8:1043-52.
• Steiner M, Brown E, Trzepacz P, Dillon J, Berger C, Carter D et al. Fluoxetine improves functional work capacity in women with premenstrual dysphoric disorder. Arch Womens Ment Health. 2003;6:71-7.
• Diener D, Greenstein FL, Turnbough PD. Cyclical variation in digit-span and visual-search performance in women differing in the severity of their premenstrual symptoms. Percept Mot Skills. 1992;74:67-76.
• Keenan P, Stern RA, Janowsky DS, Pedersen CA. Psychological aspects of premenstrual syndrome I: cognition and memory. Psychoneuroendocrinology. 1992;17:179-87.
• Posthuma BW, Bass MJ, Bull SB, Nisker JA. Detecting changes in functional ability in women with premenstrual syndrome. Am J Obstet Gynecol. 1987;156:275-8.
• Reed SC, Levin FR, Evans SM. Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder). Horm Behav. 2008;54:185-93.
• Pençe S. Cerebral lateralization. Van Medical Journal. 2000;7:120.
• Wisniewski AB. Sexually-dimorphic patterns of cortical asymmetry, and the role for sex steroid hormones in determining cortical patterns of lateralization. Psychoneuroendocrinology. 1998;23:519-47.
• Elalmis DD, Özgünen KT, Binokay S, Tan M, Özgünen T, Tan Ü. Differential contributions of right and left brains to paw skill in right-and left-pawed female rats. Int J Neurosci. 2003;113:1023-41.
• Dragovic M, Hammond G. Handedness in schizophrenia: a quantitative review of evidence. Acta Psychiatr Scand. 2005;111:410-9.
• Flyckt L, Sydow O, Bjerkenstedt L, Edman G, Rydin E, Wiesel F-A. Neurological signs and psychomotor performance in patients with schizophrenia, their relatives and healthy controls. Psychiatry Res. 1999;86:113-29.
• Habib M. The neurological basis of developmental dyslexia: an overview and working hypothesis. Brain. 2000;123:2373-99.
• Preslar J, Kushner HI, Marino L, Pearce B. Autism, lateralisation, and handedness: a review of the literature and meta-analysis. Laterality. 2014;19:64-95.
• Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36:980-8.
• Gökler B, Ünal F, Pehlivantürk B, Kültür EÇ, Akdemir D, Taner Y. The Validity and Reliability of the Interview Schedule for Affective Disorders and Schizophrenia for School-Age Children-Now and Lifetime Version-Turkish Adaptation. Turk J Child Adolesc Ment Health. 2004;11:109-16.
• Porteus S. Recent maze test studies. Br J Med Psychol. 1959;32:38-43.
• Krikorian R, Bartok JA. Developmental data for the Porteus maze test. Clin Neuropsychol. 1998;12:305-10.
• Halbreich U, Endicott J, Schacht S, Nee J. The diversity of premenstrual changes as reflected in the Premenstrual Assessment Form. Acta Psychiatr Scand. 1982;65:46-65.
• Dereboy Ç, Dereboy İF, Yiğitol F, Coşkun A. Premenstrüel Değerlendirme Formunun psikometrik verileri: Küme analitik bir çalışma. Turk Psikiyatri Derg. 1994;5:83-90.
• Harris AJ. Lateral dominance, directional confusion, and reading disability. J Psychol. 1957;44:283-94.
• Öner N. Examples of Psychological Tests Used In Turkey. İatanbul, Boğaziçi Ünv. Yayinevi, 2008.
• Schmidt PJ, Nieman LK, Danaceau MA, Adams LF, Rubinow DR. Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome. N Engl J Med. 1998;338:209-16.
• Barth C, Villringer A, Sacher J. Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Front Neurosci. 2015;9:37.
• Bethea CL, Lu NZ, Gundlah C, Streicher JM. Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol. 2002;23:41-100.
• Rapkin AJ, Edelmuth E, Chang L, Reading AE, McGuire MT, Su TP. Whole-blood serotonin in premenstrual syndrome. Obstet Gynecol. 1987;70:533-7.
• Güntürkün O, Ströckens F, Ocklenburg S. Brain lateralization: a comparative perspective. Physiol Rev. 2020;100:1019-63.
• Willems RM, der Haegen LV, Fisher SE, Francks C. On the other hand: including left-handers in cognitive neuroscience and neurogenetics. Nat Rev Neurosci. 2014;15:193-201.
• Boles DB, Barth JM, Merrill EC. Asymmetry and performance: Toward a neurodevelopmental theory. Brain Cogn. 2008;66:124-39.
• Lenneberg E. Biological Foundations Of Language. New York: Wiley, 1967.
• Papadopoulou AK, Vlachos F, Papadatou-Pastou M. Cerebral lateralization of language in children at risk for dyslexia: A review of neuroscientific evidence. Dialogues Clin Neurosci. 2022;5:89-97.
• Foundas A, Corey D, Angeles V, Bollich A, Crabtree–Hartman E, Heilman K. Atypical cerebral laterality in adults with persistent developmental stuttering. Neurology. 2003;61:1378-85.
• Goodarzi N, Dabbaghi P, Valipour H, Vafadari B. Pilot study: The role of the hemispheric lateralization in mental disorders by use of the limb (eye, hand, foot) dominance. Basic Clin Neurosci. 2015;6:101.
• Steele J, Uomini N. Humans, tools and handedness. Stone knapping: the necessary conditions for a uniquely hominin behaviour. Cambridge, McDonald Institute for Archaeological Research, 2005.