Otonom kortizol sekresyonu olan hastalarda ve fonksiyonel olmayan adrenal kitleleri olan hastalarda viseral yağ dokusunun karşılaştırılması

Year 2023, Volume: 48 Issue: 3, 911 - 918, 30.09.2023

Ferhat Can Pişkin , Fulya Odabaş , Ulcaz Perihan Aksoydan , Gamze Akkuş

https://doi.org/10.17826/cumj.1319639

Abstract

Amaç: Bu çalışmada sürekli otonom kortizol sekresyonunun (OKS) viseral adipoz doku, abdominal subkutan yağ dokusu ve total vücut yağı üzerindeki etkisinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Merkezimize sevk edilen adrenal kitlesi olan hastalar (n=57, kadın/erkek; 36/21) bu çalışmaya alındı. OKS'li otuz bir (n =31) hasta ve fonksiyonel olmayan adrenal insidentalomlu (FOAİ) 26 hasta dahil edildi. Hormonal değerlendirmeye yapıldı. Total, viseral ve subkutan yağ dokusu 3.0 T manyetik rezonans görüntüleme (Ingenia, Philips Medical Systems, Best, Hollanda) kullanılarak ölçüldü.
Bulgular: Ortalama yaş, cinsiyet ve vücut kitle indeksi ölçümleri OKS'li hastalar ile FOAİ'li hastalar arasında benzerdi. Toplam (422,1±131,3'e karşı 346,2±86,0 cm3) ve viseral yağ dokusu (199,9±77,3'e karşı 160,6±60,8 cm3) hacimleri, OKS'li hastalarda FOAİ'li hastalara göre artmıştı. Diabetes mellitus varlığı ve hepatosteatoz, OKS'li hastalar ile FOAİ'li hastalar arasında benzerdi. Deri altı yağ dokusu hacimleri, viseral/deri altı ve viseral/toplam yağ oranı iki grupta benzerdi.
Sonuç: OKS'li hastalarda total ve viseral yağ dokusu hacimleri cinsiyet, yaş ve BMI uyumlu FOAİ hastalarına göre daha yüksekti. Bu, OKS'li hastalarda sürekli hafif / hafif otonom kortizol sekresyonunun etkisini açıklayabilir.

Keywords

Otonom kortizol sekresyonu, fonksiyonel olmayan adrenal kitleleri, viseral yağ dokusu, manyetik rezonans görüntüleme

Comparison of visceral adipose tissue in patients with autonomous cortisol secretion and patients with the nonfunctional adrenal masses

Abstract

Purpose: This study aimed to explore the impact of continuous autonomous cortisol secretion on visceral (VAT), abdominal subcutaneous (SAT) adipose tissue, and total body fat.
Materials and Methods: A total of 57 patients (36 female, 21 male) with adrenal masses, referred to our single center, were included in this study. Among them, 31 patients had adrenal cortical carcinoma (ACS) and 26 had nonfunctional adrenal mass (NFAM). Hormonal evaluation was conducted for all patients. Measurements of total, visceral, and subcutaneous adipose tissue were performed using 3.0 T magnetic resonance imaging (Ingenia, Philips Medical Systems, Best, The Netherlands).
Results: Mean age, gender distribution, and body mass index (BMI) were comparable between patients with ACS and NFAM. Patients with ACS exhibited higher volumes of both total (422.1±131.3 vs. 346.2±86.0 cm3) and visceral adipose tissue (199.9±77.3 vs. 160.6±60.8 cm3) compared to those with NFAM. Incidence rates of diabetes mellitus and hepatosteatosis were similar in both groups. Subcutaneous adipose tissue volumes, visceral-to-subcutaneous ratio, and visceral-to-total fat ratio showed no significant differences between the two groups.
Conclusion: Patients with ACS demonstrated increased total and visceral fat tissue volumes compared to NFAM patients matched for gender, age, and BMI. This observation may elucidate the potential influence of continuous mild autonomous cortisol secretion in ACS patients. Such findings could serve as indicators of heightened cardiovascular risk among ACS patients.

Keywords

Autonomus cortisol secretion, nonfunctional adrenal incidentalomas, visceral adipose tissue, magnetic resonance imaging

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