Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

Year 2024, Volume: 49 Issue: 2, 460 - 470, 30.06.2024

İlkin İyigündoğdu , Eda Derle , Zeynep Kaya Güven Girgin , Sevgi İkbali Afşar , Oya Ümit Yemişçi , Berna Alkan , Seda Kibaroglu , Ülkü Sibel Benli

https://doi.org/10.17826/cumj.1431880

Abstract

Purpose: We aimed to evaluate the clinical characteristics of Guillain Barré syndrome (GBS) patients retrospectively and identify the prognostic factors associated with worse outcome at discharge and at the end of the first month in patients with GBS.
Materials and Methods: Patients who were followed up with the diagnosis of GBS were evaluated retrospectively. Demographic characteristics of the patients, cerebrospinal fluid examinations, treatment regimens, Medical Research Council (MRC) and Hughes Motor Scale (HMS) scores were recorded and HMS ≥3 was accepted as associated with poor prognosis in patients. SPSS version 25 program was used in the statistical analysis of the data. p<0.05 was found to be statistically significant.
Results: After the exclusion criteria 82 patients were evaluated in this study. The mean age of patients was 56.88±17.14 years and 57.3% (n=47) of the patients were male. The most common neurological finding was paresis in the lower extremities (n=67, 81.7%) followed by paresis in the upper extremities (n=48, 58.5%). Presence of paresis in lower extremities, the median of the duration of hospitalization and the mean of MRC scores at admission were statistically significantly different in patients with poor prognosis at discharge and at the end of the first month.
Conclusion: Since patients may have different clinical and electrophysiological characteristics between countries, we believe that there is a need for various publications from different countries to collect information related to the clinical features and prognosis of patients, and we think our study will contribute to these data.

Keywords

Guilain Barré syndrome, prognosis, Hughes Motor Scale

Guillain Barré sendromu olan hastaların klinik özellikleri ve fonksiyonel sonuçlarla ilişkili faktörler

Abstract

Amaç: Bu çalışmada Guillain Barré sendromu (GBS) olan hastaların klinik özelliklerini retrospektif olarak değerlendirmeyi ve taburculuk ile birinci ayın sonunda kötü prognozla ilişkili prognostik faktörleri belirlemeyi amaçladık.
Gereç ve Yöntem: GBS tanısıyla takip edilen hastalar geriye dönük olarak değerlendirildi. Hastaların demografik özellikleri, beyin omurilik sıvısı sonuçları, muayene bulguları, tedavi rejimleri, Medical Research Council (MRC) ve Hughes Motor Skalası (HMS) değerleri kaydedildi ve HMS ≥3 hastalar kötü prognoz ile ilişkili kabul edildi. Verilerin istatistiksel analizinde SPSS (versiyon 25) programı kullanıldı. p<0.05 istatistiksel olarak anlamlı bulundu.
Bulgular: Dışlama kriterleri sonrasında 82 hasta çalışmaya dahil edildi. Hastaların ortalama yaşı 56.88±17.14 yıl olup, hastaların %57.3'ü (n=47) erkekti. En sık görülen nörolojik bulgu alt ekstremitede parezi (n=67, %81.7) iken bunu üst ekstremitede parezi (n=48, %58.5) izlemekteydi. Alt ekstremitede parezi varlığı, yatış süresi ortancası ve başvuru anındaki MRC skorlarının ortalaması kötü ve iyi prognozlu hastalarda taburculukta ve birinci ay sonunda istatistiksel olarak anlamlı derecede farklıydı.
Sonuç: Hastalar ülkeler arasında farklı klinik ve elektrofizyolojik özelliklere sahip olabileceğinden hastaların klinik özellikleri ve prognozlarına ilişkin bilgi toplamak için farklı ülkelerden çeşitli yayınlara ihtiyaç duyulduğunu ve çalışmamızın bu verilere katkı sağlayacağını düşünüyoruz.

Keywords

Guillain Barré sendromu, prognoz, Hughes Motor Skalası

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