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Sağlıklı bireylerde kraniyovertebral bileşkenin referans değerlerinin bilgisayarlı tomografi ile belirlenmesi

Yıl 2025, Cilt: 50 Sayı: 3, 732 - 743, 30.09.2025
https://doi.org/10.17826/cumj.1708045

Öz

Amaç: Bu çalışma, sağlıklı bireylerde kraniovertebral bileşkenin klinik ve anatomik özelliklerini inceleyerek, cerrahi planlama ve değerlendirmelere yönelik referans veriler oluşturmayı amaçlamaktadır.
Gereç ve Yöntem: Dens transvers uzunluğu (DTU), dens anteroposterior uzunluğu (DAPU), dens yüksekliği (DY), dens ucu (DU), atlantooksipital eklem açısı (AOEA), basion ile opistion arasındaki uzaklık (BOU), axis yüksekliği (AY), atlantooksipital aralık (AOA), Welcher bazal açısı (WBA), klivus kanal açısı (KKA), Klaus yükseklik indeksi (KYI), anterior atlanto-dental aralık (AADA) ve posterior atlanto dental aralık (PADA) içeren bilgisayarlı tomografi (BT) görüntüleri, 18-60 yaşları arasındaki 180 sağlıklı bireyde retrospektif olarak değerlendirilmiştir.
Bulgular: Ölçüm sonuçları aşağıdaki gibi bulunmuştur: DTU 10.35±0.83 mm, DAPU 11,45±0,95 mm, DY 15,70±1,44 mm, DU 1,58±0,49 mm, AOEA 118,24°±7,11°, BOU 33,58±2,79 mm, AY 34,78±2,82 mm, AOA 1,47±0,29 mm, WBA, 130,41°±5,89°, KKA 160,56°±9,94°, KYI 41,45±3,03, AADA 1,19±0,48 mm ve PADA 19,47±1,84 mm, sağlıklı bireylerde sırasıyla, Ayrıca, DTU, DAPU, DY, BOU, AH, AADI ve PADI gibi bazı parametreler erkeklerde kadınlara göre anlamlı derecede yüksekti, DTU, DY, DU, AY ve AOA parametreleri yaşlar arasında anlamlı farklılık gösterdi,
Sonuç: Kraniyovertebral bileşkenin ayrıntılı anatomik ve radyolojik bilgisi, kompleks yapısı ve kritik komşulukları nedeniyle anatomi, radyoloji, anestezi, beyin cerrahisi ve kulak burun boğaz gibi birçok klinik disiplinde önem taşır.

Kaynakça

  • Tanrisever S, Orhan M, Bahşi İ, Yalçin ED. Anatomical evaluation of the craniovertebral junction on cone-beam computed tomography images. Surg Radiol Anat. 2020;42:797-815.
  • Maheshwari S, Bhat V, Kumar K. Imaging of normal and abnormal cranio-vertebral junction-a pictorial review. J Brain Neursci. 2021;5:1-10.
  • Demir BT, Eşme S, Patat D, Bilecenoğlu B. Clinical and anatomical importance of foramen magnum and craniocervical junction structures in the perspective of surgical approaches. Anat Cell Biol. 2023;56:342-49.
  • Rokka D, Poudel SS, Chaudhary AK, Shrestha A. Evaluation of cranio-cervical junction on multidetector computed tomography. Int J Health Sci Res. 2023;13:98-105.
  • Batista UC, Joaquim AF, Fernandes YB, Mathias RN, Ghizoni E, Tedeschi H. Computed tomography evaluation of the normal craniocervical junction craniometry in 100 asymptomatic patients. Neurosurg Focus. 2015;38:E5.
  • Al-Dwairy S, Fataftah J, Al-Mousa A, Ejjo MZ, Albakri K, Mohammad A. Evaluation of the normal craniocervical junction craniometry in 137 asymptomatic patients. Int J Morphol. 2023;41:216-24.
  • Rojas CA, Bertozzi JC, Martinez CR, Whitlow J. Reassessment of the craniocervical junction: Normal values on CT. AJNR Am J Neuroradiol. 2007;28:1819-23.
  • Gaunt T, Mankad K, Calder A et al. Abnormalities of the craniovertebral junction in the paediatric population: a novel biomechanical approach. Clin Radiol. 2018;73:839-54.
  • Nalbant A, Bedre Duygu O, Temelci H, Oner Z, Oner S. Evaluation of Craniovertebral Junction Anatomy by Gender and Age in the Anatolian Population. EJMI. 2024;8:35-42.
  • Arıncı K, Elhan A. Anatomy. 1. Ed. Ankara: Güneş Medicine Press, 2020;6-86.
  • Dahdaleh NS, El-Tecle N, Cloney MB, Shlobin NA, Koski TR, Wolinsky JP. Functional Anatomy and Biomechanics of the Craniovertebral Junction. World Neurosurg. 2023;175:165-71.
  • Goel A. A Review of a New Clinical Entity of 'Central Atlantoaxial Instability': Expanding Horizons of Craniovertebral Junction Surgery. Neurospine. 2019;1:186-94.
  • Kwong Y, Rao N, Latief K. Craniometric measurements in the assessment of craniovertebral settling: are they still relevant in the age of cross-sectional imaging? AJR Am J Roentgenol. 2011;196:421-5.
  • Riew KD, Hilibrand AS, Palumbo MA, Sethi N, Bohlman HH. Diagnosing basilar invagination in the rheumatoid patient. The reliability of radiographic criteria. J Bone Jt Surg Am. 2001;83:194-200.
  • Gonzalez LF, Fiorella D, Crawford NR, Wallace RC, Feiz Erfan I et al. Vertical atlantoaxial distraction injuries: radiological criteria and clinical implications. J Neurosurg Spine. 2004;1:273–80.
  • Kaya M, Ceylan D, Kaçıra T, Keskin E, Çelenk Y et al. Measuring the shape and dimensions of normal the bony structures in the craniovertebral junction from computed tomography images of the pediatric age group. Ulus Travma Acil Cerrahi Derg. 2022;28:997-1007.
  • Kosif R, Huvaj S, Abanonu E. Morphometric analysis of occipital region and cervical height in female and male. Gulhane Med J. 2007;49:173-7.
  • Hussain I, Winston GM, Goldberg J, Curri C, Williams N et al. Impact of imaging modality, age, and gender on craniocervical junction angles in adults without structural pathology. J Craniovertebr Junction Spine. 2019;10:240-6.
  • Smoker WR. Craniovertebral junction: Normal anatomy, craniometry, and congenital anomalies. Radiographics. 1994;14:255-77.
  • Menezes AH, Traynelis VC. Anatomy and biomechanics of normal craniovertebral junction (a) and biomechanics of stabilization (b). Child's Nervous System. 2008;24:1091-100.
  • Noble ER, Smoker WR. The forgotten condyle: the appearance, morphology, and classification of occipital condyle fractures. AJNR Am J Neuroradiol. 1996;17:507-13.
  • Kulkarni AG, Shah SM, Marwah RA, Hanagandi PB, Talwar IR. CT based evaluation of odontoid morphology in the Indian population. Indian J Orthop. 2013;47:250-4.
  • Teo EC, Hailibkova S, Winkelstein B, Welch W, Holsgrove T, Cazzola D. Morphometric analysis of human second cervical vertebrae (axis). J Spine.2017;6:1-7.
  • Johal A, Chaggar A, Zou LF. A three-dimensional soft tissue analysis of Class III malocclusion: a case-controlled cross-sectional study. J Orthod. 2018;45:16-22.
  • Oliveira TM, Claudino LV, Mattos CT, Sant'Anna EF. Maxillary dentoalveolar assessment following retraction of maxillary incisors: a preliminary study. Dental Press J Orthod. 2016;21:82-9.
  • Koenigsberg RA, Vakil N, Hong TA et al. Evaluation of platybasia with MR imaging. AJNR Am J Neuroradiol. 2005;2:89-92.
  • Xia Y, Xia H, Tang W, Wang S, Yan Y. Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination. J Integr Neurosci. 2022;21:70-8.
  • Yoon K, Cha SW, Ryu JA, Park DW, Lee S, Joo KB. Anterior Atlantodental and Posterior Atlantodental Intervals on Plain Radiography, Multidetector CT, and MRI. J Korean Soc Radiol. 2015;72:57-64.
  • Miranda-Viana M, Freitas DQ, Gomes AF, Prado FB, Nejaim Y. Classification and Morphological Analysis of the Hard Palate in Cone-Beam Computed Tomography Scans: A Retrospective Study. J Oral Maxillofac Surg. 2021;79:695.e1-13.
  • Ekuma EM, Ndubuisi CA, Mezue W, Ohaegbulam S. Normal Atlanto-Occipital Interval in Adults of Southeast Nigeria: An Evaluation of the Effect of Age, Sex, and Race. World Neurosurg. 2019;126:e1012-6.
  • Naderi S, Cakmakçi H, Acar F, Arman C, Mertol T, Arda MN. Anatomical and computed tomographic analysis of C1 vertebra. Clin Neurol Neurosurg. 2003;105:245-8.
  • Yousuf SM, Gulzar S, Itoo MS, Bhat GM, Khan MA. Morphometric study of dens and its clinical importance. Int J Res Med Sci. 2023;11:1268-1.
  • Yadav V, Prasad RS, Sahu A, Mishra MK, Pradhan RS. Morphometric analysis of posterior cranial fossa and foramen magnum and it’s clinical implications in craniovertebral junction malformations: a computed tomography based institutional study in a tertiary care hospital of northern part of India.Egypt J Neurosurg. 2024;39:12-25.
  • Khanal UP. Evaluation of Cranio-Vertebral Junction by Multidetector Computer Tomography. Ann Clin Med Case Rep. 2023;11:1-7.
  • Dash C, Singla R, Agarwal M, Kumar A, Kumar H, Mishra S, Sharma BS. Craniovertebral junction evaluation by computed tomography in asymptomatic individuals in the Indian population. Neurol India. 2018;66:797-3.
  • Küçükoğlu İ, Orhan M, Bahşi İ. Morphometric and Morphological Evaluation of the Atlas: Anatomic Study and Clinical Implications. European Journal of Therapeutics.2022;28:96-101.
  • Benke M, Yu WD, Peden SC, O'Brien JR. Occipitocervical junction: imaging, pathology, instrumentation. Am J Orthop (Belle Mead NJ). 2011;40:E205-15.
  • Şengül G, Kadioglu HH. Morphometric anatomy of the atlas and axis vertebrae. Turkish Neurosurgery. 2006;16:69-76.
  • Henderson FC Sr, Henderson FC Jr, Wilson WA 4th, Mark AS, Koby M. Utility of the clivo-axial angle in assessing brainstem deformity: pilot study and literature review. Neurosurg Rev. 2018;41:149-63.
  • Nascimento JJ, Neto EJ, Mello‑Junior CF, Valença MM, Araújo‑Neto SA, Diniz PR. Diagnostic accuracy of classical radiological measurements for basilar invagination of type B at MRI. Eur Spine J. 2019;28:345‑52.
  • Henderson FC Sr, Francomano CA, Koby M, Tuchman K, Adcock J, Patel S. Cervical medullary syndrome secondary to craniocervical instability and ventral brainstem compression in hereditary hypermobility connective tissue disorders: 5‑year follow‑up after craniocervical reduction, fusion, and stabilization. Neurosurg Rev. 2019;42:915‑36.
  • Ravindra VM, Onwuzulike K, Heller RS, Quigley, Smith J, Dailey AT et al. Chiari-related scoliosis: a single-center experience with long-term radiographic follow-up and relationship to deformity correction. J Neurosurg Pediatr. 2018;21:185-9.
  • Asal N, Şahan MH. Is there a relationship between migraine disease and the skull base angles?. 2018;10:456-70.

Determination of reference values of the craniovertebral junction in healthy individuals using computed tomography

Yıl 2025, Cilt: 50 Sayı: 3, 732 - 743, 30.09.2025
https://doi.org/10.17826/cumj.1708045

Öz

Purpose: This study aims to investigate the clinical and anatomical characteristics of the craniovertebral junction in healthy individuals to establish reference data for surgical planning and evaluation.
Materials and Methods: The Computed Tomography (CT) images including, dens transverse length (DTL), dens anteroposterior length (DAPL), dens height (DH), dens tip (DT), atlantooccipital joint angle (AOJA), distance between basion to opistion (BOD), axis height (AH), atlantooccipital interval (AOI), Welcher basal angle (WBA), clivus canal angle (CCA), Klaus height index (KHI), anterior atlanto-dental interval (AADI), and posterior atlanto dental interval (PADI) of 180 healthy individuals between 18-60 years were retrospectively evaluated.
Results: Measurement results were found as follows: DTL 10.35±0.83 mm, DAPL 11.45±0.95 mm, DH 15.70±1.44 mm, DT 1.58±0.49 mm, AOJA 118.24±7.11°, BOD 33.58±2.79 mm, AH 34.78±2.82 mm, AOI 1.47±0.29 mm, WBA, 130.41±5.89°, CCA 160.56±9.94°, KHI 41.45±3.03, AADI 1.19±0.48 mm, and PADI, 19.47±1.84 mm, in healthy subjects, respectively. Additionally, some parameters, including DTL, DAPL, DH, BOD, AH, AADI, and PADI, were significantly higher in males than in females. DTL, DH, DT, AH, and AOI parameters showed a significant difference between ages.
Conclusion: Detailed anatomical and radiological knowledge of the craniovertebral junction is crucial in various clinical disciplines, including anatomy, radiology, anesthesiology, neurosurgery, and otolaryngology, due to its complex structure and critical anatomical relationships.

Etik Beyan

This retrospective observational study was approved by the Clinical Research Ethics Committee (Decision No: 2025/151-7).

Destekleyen Kurum

No

Teşekkür

No

Kaynakça

  • Tanrisever S, Orhan M, Bahşi İ, Yalçin ED. Anatomical evaluation of the craniovertebral junction on cone-beam computed tomography images. Surg Radiol Anat. 2020;42:797-815.
  • Maheshwari S, Bhat V, Kumar K. Imaging of normal and abnormal cranio-vertebral junction-a pictorial review. J Brain Neursci. 2021;5:1-10.
  • Demir BT, Eşme S, Patat D, Bilecenoğlu B. Clinical and anatomical importance of foramen magnum and craniocervical junction structures in the perspective of surgical approaches. Anat Cell Biol. 2023;56:342-49.
  • Rokka D, Poudel SS, Chaudhary AK, Shrestha A. Evaluation of cranio-cervical junction on multidetector computed tomography. Int J Health Sci Res. 2023;13:98-105.
  • Batista UC, Joaquim AF, Fernandes YB, Mathias RN, Ghizoni E, Tedeschi H. Computed tomography evaluation of the normal craniocervical junction craniometry in 100 asymptomatic patients. Neurosurg Focus. 2015;38:E5.
  • Al-Dwairy S, Fataftah J, Al-Mousa A, Ejjo MZ, Albakri K, Mohammad A. Evaluation of the normal craniocervical junction craniometry in 137 asymptomatic patients. Int J Morphol. 2023;41:216-24.
  • Rojas CA, Bertozzi JC, Martinez CR, Whitlow J. Reassessment of the craniocervical junction: Normal values on CT. AJNR Am J Neuroradiol. 2007;28:1819-23.
  • Gaunt T, Mankad K, Calder A et al. Abnormalities of the craniovertebral junction in the paediatric population: a novel biomechanical approach. Clin Radiol. 2018;73:839-54.
  • Nalbant A, Bedre Duygu O, Temelci H, Oner Z, Oner S. Evaluation of Craniovertebral Junction Anatomy by Gender and Age in the Anatolian Population. EJMI. 2024;8:35-42.
  • Arıncı K, Elhan A. Anatomy. 1. Ed. Ankara: Güneş Medicine Press, 2020;6-86.
  • Dahdaleh NS, El-Tecle N, Cloney MB, Shlobin NA, Koski TR, Wolinsky JP. Functional Anatomy and Biomechanics of the Craniovertebral Junction. World Neurosurg. 2023;175:165-71.
  • Goel A. A Review of a New Clinical Entity of 'Central Atlantoaxial Instability': Expanding Horizons of Craniovertebral Junction Surgery. Neurospine. 2019;1:186-94.
  • Kwong Y, Rao N, Latief K. Craniometric measurements in the assessment of craniovertebral settling: are they still relevant in the age of cross-sectional imaging? AJR Am J Roentgenol. 2011;196:421-5.
  • Riew KD, Hilibrand AS, Palumbo MA, Sethi N, Bohlman HH. Diagnosing basilar invagination in the rheumatoid patient. The reliability of radiographic criteria. J Bone Jt Surg Am. 2001;83:194-200.
  • Gonzalez LF, Fiorella D, Crawford NR, Wallace RC, Feiz Erfan I et al. Vertical atlantoaxial distraction injuries: radiological criteria and clinical implications. J Neurosurg Spine. 2004;1:273–80.
  • Kaya M, Ceylan D, Kaçıra T, Keskin E, Çelenk Y et al. Measuring the shape and dimensions of normal the bony structures in the craniovertebral junction from computed tomography images of the pediatric age group. Ulus Travma Acil Cerrahi Derg. 2022;28:997-1007.
  • Kosif R, Huvaj S, Abanonu E. Morphometric analysis of occipital region and cervical height in female and male. Gulhane Med J. 2007;49:173-7.
  • Hussain I, Winston GM, Goldberg J, Curri C, Williams N et al. Impact of imaging modality, age, and gender on craniocervical junction angles in adults without structural pathology. J Craniovertebr Junction Spine. 2019;10:240-6.
  • Smoker WR. Craniovertebral junction: Normal anatomy, craniometry, and congenital anomalies. Radiographics. 1994;14:255-77.
  • Menezes AH, Traynelis VC. Anatomy and biomechanics of normal craniovertebral junction (a) and biomechanics of stabilization (b). Child's Nervous System. 2008;24:1091-100.
  • Noble ER, Smoker WR. The forgotten condyle: the appearance, morphology, and classification of occipital condyle fractures. AJNR Am J Neuroradiol. 1996;17:507-13.
  • Kulkarni AG, Shah SM, Marwah RA, Hanagandi PB, Talwar IR. CT based evaluation of odontoid morphology in the Indian population. Indian J Orthop. 2013;47:250-4.
  • Teo EC, Hailibkova S, Winkelstein B, Welch W, Holsgrove T, Cazzola D. Morphometric analysis of human second cervical vertebrae (axis). J Spine.2017;6:1-7.
  • Johal A, Chaggar A, Zou LF. A three-dimensional soft tissue analysis of Class III malocclusion: a case-controlled cross-sectional study. J Orthod. 2018;45:16-22.
  • Oliveira TM, Claudino LV, Mattos CT, Sant'Anna EF. Maxillary dentoalveolar assessment following retraction of maxillary incisors: a preliminary study. Dental Press J Orthod. 2016;21:82-9.
  • Koenigsberg RA, Vakil N, Hong TA et al. Evaluation of platybasia with MR imaging. AJNR Am J Neuroradiol. 2005;2:89-92.
  • Xia Y, Xia H, Tang W, Wang S, Yan Y. Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination. J Integr Neurosci. 2022;21:70-8.
  • Yoon K, Cha SW, Ryu JA, Park DW, Lee S, Joo KB. Anterior Atlantodental and Posterior Atlantodental Intervals on Plain Radiography, Multidetector CT, and MRI. J Korean Soc Radiol. 2015;72:57-64.
  • Miranda-Viana M, Freitas DQ, Gomes AF, Prado FB, Nejaim Y. Classification and Morphological Analysis of the Hard Palate in Cone-Beam Computed Tomography Scans: A Retrospective Study. J Oral Maxillofac Surg. 2021;79:695.e1-13.
  • Ekuma EM, Ndubuisi CA, Mezue W, Ohaegbulam S. Normal Atlanto-Occipital Interval in Adults of Southeast Nigeria: An Evaluation of the Effect of Age, Sex, and Race. World Neurosurg. 2019;126:e1012-6.
  • Naderi S, Cakmakçi H, Acar F, Arman C, Mertol T, Arda MN. Anatomical and computed tomographic analysis of C1 vertebra. Clin Neurol Neurosurg. 2003;105:245-8.
  • Yousuf SM, Gulzar S, Itoo MS, Bhat GM, Khan MA. Morphometric study of dens and its clinical importance. Int J Res Med Sci. 2023;11:1268-1.
  • Yadav V, Prasad RS, Sahu A, Mishra MK, Pradhan RS. Morphometric analysis of posterior cranial fossa and foramen magnum and it’s clinical implications in craniovertebral junction malformations: a computed tomography based institutional study in a tertiary care hospital of northern part of India.Egypt J Neurosurg. 2024;39:12-25.
  • Khanal UP. Evaluation of Cranio-Vertebral Junction by Multidetector Computer Tomography. Ann Clin Med Case Rep. 2023;11:1-7.
  • Dash C, Singla R, Agarwal M, Kumar A, Kumar H, Mishra S, Sharma BS. Craniovertebral junction evaluation by computed tomography in asymptomatic individuals in the Indian population. Neurol India. 2018;66:797-3.
  • Küçükoğlu İ, Orhan M, Bahşi İ. Morphometric and Morphological Evaluation of the Atlas: Anatomic Study and Clinical Implications. European Journal of Therapeutics.2022;28:96-101.
  • Benke M, Yu WD, Peden SC, O'Brien JR. Occipitocervical junction: imaging, pathology, instrumentation. Am J Orthop (Belle Mead NJ). 2011;40:E205-15.
  • Şengül G, Kadioglu HH. Morphometric anatomy of the atlas and axis vertebrae. Turkish Neurosurgery. 2006;16:69-76.
  • Henderson FC Sr, Henderson FC Jr, Wilson WA 4th, Mark AS, Koby M. Utility of the clivo-axial angle in assessing brainstem deformity: pilot study and literature review. Neurosurg Rev. 2018;41:149-63.
  • Nascimento JJ, Neto EJ, Mello‑Junior CF, Valença MM, Araújo‑Neto SA, Diniz PR. Diagnostic accuracy of classical radiological measurements for basilar invagination of type B at MRI. Eur Spine J. 2019;28:345‑52.
  • Henderson FC Sr, Francomano CA, Koby M, Tuchman K, Adcock J, Patel S. Cervical medullary syndrome secondary to craniocervical instability and ventral brainstem compression in hereditary hypermobility connective tissue disorders: 5‑year follow‑up after craniocervical reduction, fusion, and stabilization. Neurosurg Rev. 2019;42:915‑36.
  • Ravindra VM, Onwuzulike K, Heller RS, Quigley, Smith J, Dailey AT et al. Chiari-related scoliosis: a single-center experience with long-term radiographic follow-up and relationship to deformity correction. J Neurosurg Pediatr. 2018;21:185-9.
  • Asal N, Şahan MH. Is there a relationship between migraine disease and the skull base angles?. 2018;10:456-70.
Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi (Diğer)
Bölüm Araştırma
Yazarlar

Sema Polat 0000-0001-7330-4919

Mahmut Oksüzler 0000-0002-3730-5487

Yayımlanma Tarihi 30 Eylül 2025
Gönderilme Tarihi 28 Mayıs 2025
Kabul Tarihi 23 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 50 Sayı: 3

Kaynak Göster

MLA Polat, Sema ve Mahmut Oksüzler. “Determination of reference values of the craniovertebral junction in healthy individuals using computed tomography”. Cukurova Medical Journal, c. 50, sy. 3, 2025, ss. 732-43, doi:10.17826/cumj.1708045.