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Major jinekolojik cerrahi geçiren hastalarda postoperatif analjezide lomber epidural analjezi, transversus abdominis plan bloğu ve cerrahi yara infiltrasyonunun karşılaştırılması

Yıl 2025, Cilt: 50 Sayı: 3, 819 - 828, 30.09.2025
https://doi.org/10.17826/cumj.1709071

Öz

Amaç: Çalışmamızda major jinekolojik cerrahide lomber epidural analjezi (LEA), transversus abdominis plan (TAP) bloğu ve cerrahi yara infiltrasyonunu (SWI) postoperatif analjezi, hasta memnuniyeti ve yan etkiler açısından karşılaştırdık.
Gereç ve Yöntem: Seksen bir hasta üç gruba randomize edildi: lomber epidural blok (Grup LEA), TAP blok (Grup TAP) ve cerrahi yara infiltrasyonu (Grup SWI). Demografik veriler, cerrahi özellikler, hemodinamik değişkenler, toplam morfin tüketimi, ilk kurtarma analjezik isteğine kadar geçen süre, ağrı skorları ve yan etkiler postoperatif 1, 2, 6, 12, 24, 36 ve 48. saatlerde kaydedildi. Hasta memnuniyeti skorları da postoperatif 24 ve 48. saatlerde kaydedildi.
Bulgular: Kalp hızı Grup LEA'da diğer gruplara kıyasla daha düşüktü. Ameliyat sonrası 48 saatlik toplam morfin tüketimi Grup LEA'da (9,63±5,7 mg), Grup TAP'a (15,30±4,0 mg) ve Grup SWI'a (16,93±5,9 mg) göre anlamlı derecede düşüktü. Ameliyat sonrası ağrı skorları Grup LEA'da diğer gruplara göre anlamlı derecede düşüktü. İlk kurtarma analjezisine kadar geçen süre Grup LEA'da (47,41±24,3 dk), Grup TAP'a (27,41±11,9 dk) ve Grup SWI'ya (16,67±5,1 dk) göre anlamlı derecede uzundu. Hasta memnuniyeti skorları 24 ve 48. saatlerde Grup LEA'da (9,89±0,3 ve 9,96±0,1) Grup TAP'a (9,67±0,5 ve 9,89±0,3) ve Grup SWI'ya (9,37±0,8 ve 9,44±0,7) göre anlamlı derecede yüksekti. Postoperatif önemli bir yan etki görülmedi.
Sonuç: Majör jinekolojik cerrahi geçiren hastalarda LEA TAP blok ve SWI ile karşılaştırıldığında yan etki riskini artırmadan daha düşük morfin tüketimi, ilk kurtarma analjezi süresinde uzama ve daha yüksek hasta memnuniyet skorları ile sonuçlandı.

Kaynakça

  • ovich-Sapola J, Smith CE, Brandt CP. Postoperative pain control. Surg Clin North Am. 2015;95:301-18.
  • Kalogera E, Dowdy SC. Enhanced recovery pathway in gynecologic surgery: improving outcomes through evidence-based medicine. Obstet Gynecol Clin North Am. 2016;43:551-73.
  • Carney J, McDonnell JG, Ochana A, Bhinder R, Laffey JG. The transversus abdominis plane block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesth Analg. 2008;107(6):2056-60.
  • Guo Q, Li R, Wang L, Zhang D, Ma Y. Transversus abdominis plane block versus local anaesthetic wound infiltration for postoperative analgesia: A systematic review and meta-analysis. Int J Clin Exp Med. 2015;8:17343-52.
  • Nelson G, Bakkum-Gamez J, Kalogera E, Glaser G, Altman A, Meyer LA et al. Guidelines for perioperative care in gynecologic/oncology: Enhanced Recovery After Surgery (ERAS) Society recommendations-2019 update. Int J Gynecol Cancer. 2019;29:651-68.
  • Nelson G, Altman AD, Nick A, Meyer LA, Ramirez PT, Achtari C et al. Guidelines for postoperative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations--Part II. Gynecol Oncol. 2016;140:323-32.
  • Kaye AD, Urman RD, Rappaport Y, Siddaiah H, Cornett EM, Belani K et al. Multimodal analgesia as an essential part of enhanced recovery protocols in the ambulatory settings. J Anaesthesiol Clin Pharmacol. 2019;35:40-5.
  • Shaker TM, Carroll JT, Chung MH, Koehler TJ, Lane BR, Wolf AM et al. Efficacy and safety of transversus abdominis plane blocks versus thoracic epidural anesthesia in patients undergoing major abdominal oncologic resections: A prospective, randomized controlled trial. Am J Surg. 2018;215:498-501.
  • Mathew P, Aggarwal N, Kumari K, Gupta A, Panda N, Bagga R. Quality of recovery and analgesia after total abdominal hysterectomy under general anesthesia: A randomized controlled trial of TAP block vs epidural analgesia vs parenteral medications. J Anaesthesiol Clin Pharmacol. 2019;35:170-5.
  • Hamid HKS, Marc-Hernandez A, Saber AA. Transversus abdominis plane block versus thoracic epidural analgesia in colorectal surgery: a systematic review and meta-analysis. Langenbecks Arch Surg. 2021;406:273-82.
  • Iyer SS, Bavishi H, Mohan CV, Kaur N. Comparison of epidural analgesia with transversus abdominis plane analgesia for postoperative pain relief in patients undergoing lower abdominal surgery: A prospective randomized study. Anesth Essays Res. 2017;11:670-5.
  • Turan A, Cohen B, Elsharkawy H, Maheshwari K, Soliman LM, Babazade R et al. Transversus abdominis plane block with liposomal bupivacaine versus continuous epidural analgesia for major abdominal surgery: The EXPLANE randomized trial. J Clin Anesth. 2022;77:110640.
  • Jeong YH, Jung JY, Cho H, Yoon HK, Yang SM, Lee HJ et al. Transverse abdominis plane block compared with patient-controlled epidural analgesia following abdominal surgery: a meta-analysis and trial sequential analysis. Sci Rep. 2022;12:20606.
  • Bell R, Pandanaboyana S, Prasad KR. Epidural versus local anaesthetic infiltration via wound catheters in open liver resection: a meta-analysis. ANZ J Surg. 2015;85:16-21.
  • Ammianickal PL, Thangaswamy CR, Balachander H, Subbaiah M, Kumar NCP. Comparing epidural and wound infiltration analgesia for total abdominal hysterectomy: A randomised controlled study. Indian J Anaesth. 2018;62:759-64.
  • Bell R, Ward D, Jeffery J, Toogood GJ, Lodge JPA, Rao K et al. A Randomized controlled trial comparing epidural analgesia versus continuous local anesthetic infiltration via abdominal wound catheter in open liver resection. Ann Surg. 2019;269:413-9.
  • Hughes MJ, Harrison EM, Peel NJ, Stutchfield B, McNally S, Beattie C et al. Randomized clinical trial of perioperative nerve block and continuous local anaesthetic infiltration via wound catheter versus epidural analgesia in open liver resection (LIVER 2 trial). Br J Surg. 2015;102:1619-28.
  • Mungroop TH, Veelo DP, Busch OR, van Dieren S, van Gulik TM, Karsten TM et al. Continuous wound infiltration versus epidural analgesia after hepato-pancreato-biliary surgery (POP-UP): a randomised controlled, open-label, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:105-13.
  • Gasanova I, Alexander J, Ogunnaike B, Hamid C, Rogers D, Minhajuddin A et al. Transversus abdominis plane block versus surgical site infiltration for pain management after open total abdominal hysterectomy. Anesth Analg. 2015;121:1383-8.
  • Cai Q, Gao ML, Chen GY, Pan LH. Transversus abdominis plane block versus wound infiltration with conventional local anesthetics in adult patients underwent surgery: A systematic review and meta-analysis of randomized controlled trials. Biomed Res Int. 2020;2020:8914953.
  • Grape S, Kirkham KR, Akiki L, Albrecht E. Transversus abdominis plane block versus local anesthetic wound infiltration for optimal analgesia after laparoscopic cholecystectomy: A systematic review and meta-analysis with trial sequential analysis. J Clin Anesth. 2021;75:110450.
  • Yu N, Long X, Lujan-Hernandez JR, Succar J, Xin X, Wang X. Transversus abdominis-plane block versus local anesthetic wound infiltration in lower abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiol. 2014;14:121.
  • Grape S, Kirkham KR, Albrecht E. Transversus abdominis plane block versus local anaesthetic wound infiltration for analgesia after caesarean section: A systematic review and meta-analysis with trial sequential analysis. Eur J Anaesthesiol. 2022;39:244-51.

Comparison of lumbar epidural analgesia, transversus abdominis plane block, and surgical wound infiltration for postoperative pain relief in patients with major gynecologic surgery

Yıl 2025, Cilt: 50 Sayı: 3, 819 - 828, 30.09.2025
https://doi.org/10.17826/cumj.1709071

Öz

Purpose: This study compared lumbar epidural analgesia (LEA), transversus abdominis plane (TAP) block, and surgical wound infiltration (SWI) for postoperative analgesia, patient satisfaction, and side effects in major gynecologic surgery.
Materials and Methods: Eighty-one patients were randomized into three groups: lumbar epidural block (Group LEA), TAP block (Group TAP), and SWI (Group SWI). Demographic data, surgical characteristics, hemodynamic variables, total morphine consumption, time to first rescue analgesia, pain scores, and side effects were recorded at 1, 2, 6, 12, 24, 36, and 48 hours, along with patient satisfaction scores at 24 and 48 hours postoperatively.
Results: Heart rate was significantly lower in Group LEA than in Group SWI and Group TAP. Postoperative 48-h total morphine consumption was significantly lower in Group LEA (9.63 ± 5.7 mg) than in Group TAP (15.30 ± 4.0 mg) and Group SWI (16.93 ± 5.9 mg). Postoperative pain scores were significantly lower in Group LEA than in the other groups. Time to first rescue analgesia was significantly longer in Group LEA (47.41 ± 24.3 min) than in Group TAP (27.41 ± 11.9 min) and Group SWI (16.67 ± 5.1 min). Patient satisfaction scores were significantly higher at 24 and 48 hours in Group LEA (9.89 ± 0.3 and 9.96 ± 0.1, respectively) than in Group TAP (9.67 ± 0.5 and 9.89 ± 0.3) and Group SWI (9.37 ± 0.8 and 9.44 ± 0.7). No significant side effects were noted.
Conclusion: In patients undergoing major gynecologic surgery, LEA resulted in lower morphine consumption, longer time to first rescue analgesic request, and higher patient satisfaction scores without increasing the risk of side effects compared to TAP block and SWI.

Etik Beyan

This study was conducted in accordance with the Declaration of Helsinki, and approved by the faculty ethical committee (date: 8 September 2022, IRB number: 174/7).

Destekleyen Kurum

The authors received no financial support for the research, authorship, and/or publication of this article.

Kaynakça

  • ovich-Sapola J, Smith CE, Brandt CP. Postoperative pain control. Surg Clin North Am. 2015;95:301-18.
  • Kalogera E, Dowdy SC. Enhanced recovery pathway in gynecologic surgery: improving outcomes through evidence-based medicine. Obstet Gynecol Clin North Am. 2016;43:551-73.
  • Carney J, McDonnell JG, Ochana A, Bhinder R, Laffey JG. The transversus abdominis plane block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesth Analg. 2008;107(6):2056-60.
  • Guo Q, Li R, Wang L, Zhang D, Ma Y. Transversus abdominis plane block versus local anaesthetic wound infiltration for postoperative analgesia: A systematic review and meta-analysis. Int J Clin Exp Med. 2015;8:17343-52.
  • Nelson G, Bakkum-Gamez J, Kalogera E, Glaser G, Altman A, Meyer LA et al. Guidelines for perioperative care in gynecologic/oncology: Enhanced Recovery After Surgery (ERAS) Society recommendations-2019 update. Int J Gynecol Cancer. 2019;29:651-68.
  • Nelson G, Altman AD, Nick A, Meyer LA, Ramirez PT, Achtari C et al. Guidelines for postoperative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations--Part II. Gynecol Oncol. 2016;140:323-32.
  • Kaye AD, Urman RD, Rappaport Y, Siddaiah H, Cornett EM, Belani K et al. Multimodal analgesia as an essential part of enhanced recovery protocols in the ambulatory settings. J Anaesthesiol Clin Pharmacol. 2019;35:40-5.
  • Shaker TM, Carroll JT, Chung MH, Koehler TJ, Lane BR, Wolf AM et al. Efficacy and safety of transversus abdominis plane blocks versus thoracic epidural anesthesia in patients undergoing major abdominal oncologic resections: A prospective, randomized controlled trial. Am J Surg. 2018;215:498-501.
  • Mathew P, Aggarwal N, Kumari K, Gupta A, Panda N, Bagga R. Quality of recovery and analgesia after total abdominal hysterectomy under general anesthesia: A randomized controlled trial of TAP block vs epidural analgesia vs parenteral medications. J Anaesthesiol Clin Pharmacol. 2019;35:170-5.
  • Hamid HKS, Marc-Hernandez A, Saber AA. Transversus abdominis plane block versus thoracic epidural analgesia in colorectal surgery: a systematic review and meta-analysis. Langenbecks Arch Surg. 2021;406:273-82.
  • Iyer SS, Bavishi H, Mohan CV, Kaur N. Comparison of epidural analgesia with transversus abdominis plane analgesia for postoperative pain relief in patients undergoing lower abdominal surgery: A prospective randomized study. Anesth Essays Res. 2017;11:670-5.
  • Turan A, Cohen B, Elsharkawy H, Maheshwari K, Soliman LM, Babazade R et al. Transversus abdominis plane block with liposomal bupivacaine versus continuous epidural analgesia for major abdominal surgery: The EXPLANE randomized trial. J Clin Anesth. 2022;77:110640.
  • Jeong YH, Jung JY, Cho H, Yoon HK, Yang SM, Lee HJ et al. Transverse abdominis plane block compared with patient-controlled epidural analgesia following abdominal surgery: a meta-analysis and trial sequential analysis. Sci Rep. 2022;12:20606.
  • Bell R, Pandanaboyana S, Prasad KR. Epidural versus local anaesthetic infiltration via wound catheters in open liver resection: a meta-analysis. ANZ J Surg. 2015;85:16-21.
  • Ammianickal PL, Thangaswamy CR, Balachander H, Subbaiah M, Kumar NCP. Comparing epidural and wound infiltration analgesia for total abdominal hysterectomy: A randomised controlled study. Indian J Anaesth. 2018;62:759-64.
  • Bell R, Ward D, Jeffery J, Toogood GJ, Lodge JPA, Rao K et al. A Randomized controlled trial comparing epidural analgesia versus continuous local anesthetic infiltration via abdominal wound catheter in open liver resection. Ann Surg. 2019;269:413-9.
  • Hughes MJ, Harrison EM, Peel NJ, Stutchfield B, McNally S, Beattie C et al. Randomized clinical trial of perioperative nerve block and continuous local anaesthetic infiltration via wound catheter versus epidural analgesia in open liver resection (LIVER 2 trial). Br J Surg. 2015;102:1619-28.
  • Mungroop TH, Veelo DP, Busch OR, van Dieren S, van Gulik TM, Karsten TM et al. Continuous wound infiltration versus epidural analgesia after hepato-pancreato-biliary surgery (POP-UP): a randomised controlled, open-label, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:105-13.
  • Gasanova I, Alexander J, Ogunnaike B, Hamid C, Rogers D, Minhajuddin A et al. Transversus abdominis plane block versus surgical site infiltration for pain management after open total abdominal hysterectomy. Anesth Analg. 2015;121:1383-8.
  • Cai Q, Gao ML, Chen GY, Pan LH. Transversus abdominis plane block versus wound infiltration with conventional local anesthetics in adult patients underwent surgery: A systematic review and meta-analysis of randomized controlled trials. Biomed Res Int. 2020;2020:8914953.
  • Grape S, Kirkham KR, Akiki L, Albrecht E. Transversus abdominis plane block versus local anesthetic wound infiltration for optimal analgesia after laparoscopic cholecystectomy: A systematic review and meta-analysis with trial sequential analysis. J Clin Anesth. 2021;75:110450.
  • Yu N, Long X, Lujan-Hernandez JR, Succar J, Xin X, Wang X. Transversus abdominis-plane block versus local anesthetic wound infiltration in lower abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiol. 2014;14:121.
  • Grape S, Kirkham KR, Albrecht E. Transversus abdominis plane block versus local anaesthetic wound infiltration for analgesia after caesarean section: A systematic review and meta-analysis with trial sequential analysis. Eur J Anaesthesiol. 2022;39:244-51.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Anesteziyoloji
Bölüm Araştırma
Yazarlar

Cansu Demir 0009-0008-7018-3304

Mediha Türktan 0000-0002-7378-6265

Ersel Güleç 0000-0002-8415-8571

Mete Sucu 0000-0002-6889-7147

Hülya Binokay 0000-0002-0162-4574

Hakki Ünlügenç 0000-0003-0164-8258

Yayımlanma Tarihi 30 Eylül 2025
Gönderilme Tarihi 17 Haziran 2025
Kabul Tarihi 30 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 50 Sayı: 3

Kaynak Göster

MLA Demir, Cansu vd. “Comparison of lumbar epidural analgesia, transversus abdominis plane block, and surgical wound infiltration for postoperative pain relief in patients with major gynecologic surgery”. Cukurova Medical Journal, c. 50, sy. 3, 2025, ss. 819-28, doi:10.17826/cumj.1709071.