Prognostic value of blood urea nitrogen-to-albumin ratio in critically ill lung cancer patients

Yıl 2025, Cilt: 50 Sayı: 3, 829 - 839, 30.09.2025

Maşide Arı , Murat Yıldız , Derya Kızılgöz , Oral Menteş , Canan Yilmaz Şahin , Cansu Görkem Yahşi , Eren Usul , Eray Çınar , Emrah Arı

https://doi.org/10.17826/cumj.1710778

Öz

urpose: This study aimed to investigate factors influencing mortality in intensive care units (ICUs)-treated lung cancer patients, focusing on the prognostic value of the blood urea nitrogen-to-serum albumin ratio (BAR).
Materials and Methods: This retrospective study included lung cancer patients treated in the ICU between 2020 and 2024. Clinical and laboratory data were collected, including demographics, reasons for ICU admission, and scores from BAR, Acute Physiology and Chronic Health Evaluation II (APACHE-II), and Sepsis-related Organ Failure Assessment (SOFA). BAR levels at admission, 24 hours, and 72 hours were analyzed for their predictive value on 30-day mortality using ROC analysis.
Results: Among 110 patients, the 30-day mortality rate was 21.8%. Increasing BAR values over time were significantly associated with mortality. The 72-hour BAR had the highest predictive power (AUC=0.783), surpassing APACHE-II and SOFA scores. Cox regression identified elevated BAR and the need for invasive mechanical ventilation (IMV) as independent predictors of mortality.
Conclusion: BAR is a valuable prognostic biomarker in ICU-managed lung cancer patients. Its dynamic assessment enhances predictive accuracy and may support early clinical decision-making.

Anahtar Kelimeler

Lung Cancer , BAR , Mortality , ICU

Yoğun bakımda izlenen akciğer kanseri hastalarında kan üre azotu/albumin oranının prognostik değeri

Öz

Amaç: Bu çalışmanın amacı, yoğun bakım ünitesinde (YBÜ) takip edilen akciğer kanseri hastalarında mortaliteyi etkileyen faktörleri araştırmak ve kan üre azotu/serum albümin oranının (BAR) prognostik değerini incelemektir.
Gereç ve Yöntem: Bu retrospektif çalışmaya, 2020 ile 2024 yılları arasında YBÜ’de tedavi edilen akciğer kanseri hastaları dahil edilmiştir. Demografik veriler, YBÜ’ye yatış nedenleri ve BAR, Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi II (APACHE-II) ve Sepsis İlişkili Organ Yetmezliği Değerlendirmesi (SOFA) skorları gibi klinik ve laboratuvar verileri toplanmıştır. Yatışta, 24. saatte ve 72. saatte ölçülen BAR düzeylerinin 30 günlük mortaliteyi öngörmedeki değeri ROC analizi ile değerlendirilmiştir.
Bulgular: Toplam 110 hasta incelenmiş olup, 30 günlük mortalite oranı %21,8 bulunmuştur. Zamanla artan BAR değerleri mortalite ile anlamlı şekilde ilişkili bulunmuştur. 72. saatteki BAR değeri, en yüksek öngörü gücüne sahipti (EAA=0,783) ve APACHE-II ile SOFA skorlarını geride bırakmıştır. Cox regresyon analizinde yüksek BAR düzeyi ve invaziv mekanik ventilasyon (İMV) ihtiyacı mortalitenin bağımsız belirleyicileri olarak saptanmıştır.
Sonuç: BAR, YBÜ’de izlenen akciğer kanseri hastalarında değerli bir prognostik biyobelirteçtir. Dinamik değerlendirmesi, öngörü gücünü artırmakta ve erken klinik karar alma süreçlerini destekleyebilmektedir.

Anahtar Kelimeler

Akciğer kanseri , BAR , Mortalite , YBÜ

Kaynakça

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